Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

Gain-of-Function Mutations inPDR1, a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells

(2013) Luís Vale-Silva et al.   INFECTION AND IMMUNITY

Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence

(2012) L. A. Vale-Silva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The changing epidemiology of healthcare-associated candidemia over three decades

(2012) Daniel Diekema et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Species Identification and Antifungal Susceptibility Testing of Candida Bloodstream Isolates from Population-Based Surveillance Studies in Two U.S. Cities from 2008 to 2011

(2012) S. R. Lockhart et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness inCandida albicans

(2012) Christoph Sasse et al.   MOLECULAR MICROBIOLOGY

Resistance to echinocandins comes at a cost

(2012) Ronen Ben-Ami et al.   Virulence

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

(2011) Sabrina Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evolutionary Dynamics of Candida albicans during In Vitro Evolution

(2011) Mian Huang et al.   EUKARYOTIC CELL

Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance

(2011) Ronen Ben-Ami et al.   JOURNAL OF INFECTIOUS DISEASES

Difference in virulence between fluconazole-susceptible and fluconazole-resistant Candida albicans in a mouse model

(2011) Bettina Schulz et al.   MYCOSES

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology of invasive candidiasis

(2010) Maiken C Arendrup   Current Opinion in Critical Care

Genomewide Expression Profile Analysis of the Candida glabrata Pdr1 Regulon

(2010) Kelly E. Caudle et al.   EUKARYOTIC CELL

Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata

(2010) Sanjoy Paul et al.   EUKARYOTIC CELL

Antibiotic resistance and its cost: is it possible to reverse resistance?

(2010) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Analysis ofcis- andtrans-Acting Elements of theCandida albicans CDR2Promoter with a Novel Promoter Reporter System

(2009) Alix T. Coste et al.   EUKARYOTIC CELL

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

(2009) Sélène Ferrari et al.   PLoS Pathogens

EUCAST Definitive Document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts

(2008) J.L. Rodriguez-Tudela et al.   CLINICAL MICROBIOLOGY AND INFECTION

Genomewide Location Analysis ofCandida albicansUpc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance

(2008) Sadri Znaidi et al.   EUKARYOTIC CELL

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

The ATP-binding cassette transporter–encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata

(2008) Riccardo Torelli et al.   MOLECULAR MICROBIOLOGY

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY