Article
Multidisciplinary Sciences
Husam Qanash, Reham Yahya, Marwah M. Bakri, Abdulrahman S. Bazaid, Sultan Qanash, Abdullah F. Shater, T. M. Abdelghany
Summary: In this study, the chemical analysis and biological activities of Kei apple methanolic extract were evaluated. The extract was found to contain chlorogenic acid, catechin, and gallic acid as the main bioactive compounds, and exhibited antioxidant, anticancer, and antibacterial activities. It also showed mild antiviral activity against human coronavirus 229E. Molecular docking study results were consistent with the experimental data. The findings suggest that Kei apple extract has the potential to be developed as an alternative therapeutic agent.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Phillip Minnaar, Neil Jolly, Louisa Beukes, Santiago Benito-Saez
Summary: Research has shown that wines and vinegars produced through different fermentation methods have varying pH levels, total acidity, soluble solids, and concentrations of specific compounds such as phenolic acids and malic acid. The selection of different fermenting agents can have a significant impact on the composition of the final product, with some combinations resulting in higher levels of certain acids and compounds. The choice of acetic acid bacteria for acetous fermentation may need to be reconsidered based on the findings of this study.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Environmental Sciences
Sultan A. M. Saghir, Mahfoudh A. M. Abdulghani, Reem S. Alruhaimi, Ahmad F. Ahmeda, Naif A. Al-Gabri, Saleh A. M. A. Alomaisi, Amirin Sadikun, Vikneswaran Murugaiyah, Ayman M. Mahmoud
Summary: This study evaluated the toxicity of the methanolic extract of A. carambola leaves (MEAC) in rats. The results showed that MEAC was safe up to a dose of 5000 mg/kg and did not have toxic effects on the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Nima Aramipour, Maryam Gholami, Mohammad Saber, Soroor Jafar Gandomi, Naser- Aldin Lashgari, Arash Sadri, Omid Sabzevari
Summary: This study shows that Neoneaster is safe and can be classified as category 5 in the GHS system based on the acute and sub-chronic oral toxicity tests conducted on Wistar rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Idrios N. Bonsou, Armelle T. Mbaveng, Gaelle S. Nguenang, Godloves F. Chi, Thomas Efferth, Victor Kuete
Summary: TTF and its most active compound (5) were found to have potential cytotoxic effects, while TTF was safe at a single oral dose of 5000mg/kg. However, caution is needed with prolonged oral administration at high doses (>1000mg/kg) due to potential renal function alterations.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Environmental Sciences
Ruijing Xuan, Hao Wu, Yingjun Li, Bingyan Wei, Lan Wang
Summary: Studies on the freshwater crab Sinopotamon henanense have shown that acute and sub-chronic exposure to Cd2+ can induce differential alterations in respiratory physiology and gill morphology. The research revealed that sub-chronic exposure resulted in lower MT content and higher MDA levels in the gills, while acute exposure decreased PPP activity and NADPH content in the hepatopancreas. Morphological changes in the sinus gland were observed in crabs exposed to 2.86 mg/L Cd2+ for 3 weeks, providing evidence for S. henanense as a biomarker of acute or long-term waterborne Cd2+ pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Angelika Gil, Paulina Nowicka, Aneta Wojdylo, Gabriele Serreli, Monica Deiana, Carlo Ignazio Giovanni Tuberoso
Summary: This study evaluated the antioxidant activity and inhibition of targeted digestive enzymes of original smoothies made from strawberry tree fruit puree and apple juice enriched with various fruits. The results showed that the addition of certain fruits increased the antioxidant activity and ability to scavenge reactive oxygen species. The smoothies also exhibited inhibitory activity on alpha-amylase and alpha-glucosidase. The total polyphenol content ranged between 535.75 mg/100 g fw and 635.96 mg/100 g fw, with Acca sellowiana providing the highest amount. Flavan-3-ols were the dominant phenolic compounds, while only smoothies enriched with Crocus sativus showed a high amount of anthocyanins. These original smoothies have potential as nutraceuticals due to their favorable antioxidant compound profile.
Article
Biochemistry & Molecular Biology
Carla M. Ribeiro-Silva, Ana Faustino-Rocha, Rui M. Gil da Costa, Rui Medeiros, Maria J. Pires, Isabel Gaivao, Adelina Gama, Maria J. Neuparth, Joana Barbosa, Francisco Peixoto, Fernao D. Magalhaes, Margarida M. S. M. Bastos, Paula A. Oliveira
Summary: This study investigated the toxic effects of eugenol and pulegone on laboratory animals for the first time, showing that these compounds can induce behavioral changes, body weight loss, and even mortality in certain doses.
Article
Environmental Sciences
Mengxue Lyu, Jingquan Liu, Xinxiang Xu, Chunling Liu, Hanhan Qin, Xuelin Zhang, Ge Tian, Han Jiang, Yuanmao Jiang, Zhanling Zhu, Shunfeng Ge
Summary: Previous studies have shown that magnesium can prevent plants from suffering from abiotic stress. In this study, we investigated the effect of magnesium on apple seedlings under aluminum toxicity. The results showed that magnesium reduced aluminum accumulation, enhanced antioxidant capacity, and improved photosynthesis and carbon-nitrogen metabolism, alleviating aluminum-induced growth inhibition in apple seedlings.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Lan Chen, Mengya Wang, Haifen Wang, Cong Zhou, Junwei Yuan, Xihong Li, Yanfang Pan
Summary: The aim of this study was to investigate the effects of different temperature and constant temperature (CT) storage environments on antioxidant ability and energy metabolism in post-harvest apple fruit. Compared to variable temperature (TF) groups, fruit stored in the CT environment showed higher quality attributes, suppressed respiration rate, and lower lipids and reactive oxygen species accumulation. The activities of antioxidant enzymes were also higher in the CT group. Moreover, the CT environment resulted in higher levels of antioxidants and better maintenance of energy status. Thus, constant temperature storage can delay fruit senescence through enhancing antioxidant capacities and maintaining higher energy status in apple fruit.
Article
Pharmacology & Pharmacy
M. Govindappa, S. Tejashree, V Thanuja, B. Hemashekhar, C. Srinivas, Omaima Nasif, Arivalagan Pugazhendhi, Vinay B. Raghavendra
Summary: This study successfully synthesized silver nanoparticles using pomegranate fruit fleshy pericarp, which exhibited antibacterial, antioxidant, and anticancer properties. The nanoparticles showed lower toxicity on normal cells but significant toxicity on cancer cells, demonstrating potential anticancer properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Yunfeng Xiao, Lanbing Zheng, Yu Dong
Summary: The study found that Jaranol was relatively safe in mice when administered orally in both acute and sub-acute toxicity tests, but caused changes in body weight and biochemical parameters. More chronic toxicity studies are recommended to ensure its safety for human use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aisha M. H. Al-Rajhi, Salem S. Salem, Asmaa A. Alharbi, T. M. Abdelghany
Summary: Green fabrication of silver nanoparticles using Kei-apple fruit extract was investigated in this study. The synthesized nanoparticles showed excellent biological activity, including anticancer and antibacterial properties. The results demonstrated the potential of Kei-apple fruit extract as a safe and promising source for the fabrication of silver nanoparticles.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Idris Macit, Erol Aydin, Akgul Tas, Muttalip Gundogdu
Summary: This study revealed the correlation between the biochemical contents and agro-morphological properties of fruits belonging to new local apple varieties, showing that these varieties are rich in biochemical contents and can be used as genetic resources in plant breeding studies.
Article
Plant Sciences
Michel-Gael F. Guefack, Francois Damen, Carine M. N. Ngaffo, Victor Kuete
Summary: This study evaluated the toxicological effects of Hypericum roeperianum bark extract on experimental animals. The acute toxicity experiment showed minimal toxicity at a dose of 5000 mg/kg body weight, while the sub-chronic toxicity experiment revealed slight toxicity in some organs at a dose of 1000 mg/kg body weight.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biotechnology & Applied Microbiology
E. A. Elsherbiny, M. A. Taher, M. H. Abd El-Aziz, S. Y. Mohamed
Summary: The study found that the filtrate of Purpureocillium lilacinum showed inhibitory effects against Penicillium digitatum by damaging the fungal cell membrane and its components. This suggests the potential application of P. lilacinum filtrate as a novel biocontrol agent for controlling orange green mould.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mohamed A. Taher, Ebtihal Khojah, Mohamed Samir Darwish, Elsherbiny A. Elsherbiny, Asmaa A. Elawady, Dawood H. Dawood
Summary: Water-soluble polysaccharides extracted from Leucaena leucocephala seeds were used to synthesize highly stable and antimicrobial silver nanoparticles (AgNPs) with significant anticancer activity against various cancer cell lines.
JOURNAL OF NANOMATERIALS
(2022)
Article
Chemistry, Applied
Xinfa Cai, Meijuan Liang, Fei Ma, Zhaowei Zhang, Xiaoqian Tang, Jun Jiang, Can Guo, Sherif Ramzy Mohamed, Amira Abdel Goda, Dawood H. Dawood, Li Yu, Peiwu Li
Summary: The study developed a nanozyme-strip based on MnO2 nanosheets for rapid detection of AFB(1), with high sensitivity and a wide detection range. The test method had a detection limit lower than the EU regulations, with high recovery rates and low coefficients of variation.
Article
Biochemistry & Molecular Biology
Mohamed A. Taher, A. A. Lo'ay, Mostafa Gouda, Safaa A. Limam, Mohamed F. M. Abdelkader, Samah O. Osman, Mohammad Fikry, Esmat F. Ali, Sayed Y. Mohamed, Hoda A. Khalil, Diaa O. El-Ansary, Sherif F. El-Gioushy, Hesham S. Ghazzawy, Aly M. Ibrahim, Mahmoud F. Maklad, Mohamed A. Abdein, Dalia M. Hikal
Summary: This study used an edible coating of gum arabic and polyvinylpyrrolidone mixed with salicylic acid to extend the shelf life of peaches and reduce fruit tissue breakdown. The results showed that the coating significantly inhibited the degrading enzyme activities and reduced browning symptoms in the fruits, indicating that the application of this edible coating could effectively maintain the quality of peaches.
Article
Food Science & Technology
Congning Zhai, Yangguang Yu, Jun Han, Junqiang Hu, Dan He, Hongyin Zhang, Jianrong Shi, Sherif Ramzy Mohamed, Dawood H. Dawood, Gang Wang, Jianhong Xu
Summary: In this study, an anaerobic ZEN-degrading bacterium named F39 was isolated from animal intestinal contents and identified as Clostridium sporogenes. F39 showed a high efficiency in degrading ZEN and converting it into alpha- and beta-zearalenol, reducing the toxicity of degradation products. Additionally, F39 exhibited higher degradation efficiency in wheat-based feedstuffs compared to other feedstuffs, and the efficiency was pH related.
Article
Agriculture, Dairy & Animal Science
Hamada Elwan, Abdelhameed S. A. Mohamed, Dawood Hosni Dawood, Shaaban S. Elnesr
Summary: This study investigated the use of in ovo injection of Arctostaphylos uva-ursi methanolic extract to mitigate the harmful effects of aflatoxin on chicken embryos. The results showed that in ovo injection alleviated aflatoxin-induced embryotoxicity by enhancing chicks' physiological responses and optimizing antioxidant status.
Article
Agriculture, Multidisciplinary
Junqiang Hu, Gang Wang, Mingxuan Hou, Shilong Du, Jun Han, Yangguang Yu, Hongxia Gao, Dan He, Jianrong Shi, Yin-Won Lee, Sherif Ramzy Mohamed, Dawood H. Dawood, Qing Hong, Xin Liu, Jianhong Xu
Summary: In this study, a ZEN-degrading Aeromicrobium strain was isolated from soil, and ZenH, a hydrolase, was found responsible for the hydrolysis of ZEN. ZenH exhibited maximum enzymatic activity at pH 7.0 and 55 degrees C, with a Michaelis constant of 12.64 μM. The catalytic triad of ZenH was identified as S117-D142-H292, and it catalyzed the hydrolysis of ZEN to a novel metabolite with significantly lower estrogenic toxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xin Liu, Shuang Wang, Zhongyue Fan, Jiawen Wu, Liwen Wang, Dan He, Sherif Ramzy Mohamed, Dawood H. Dawood, Jianrong Shi, Tao Gao, Jianhong Xu
Summary: Fusarium crown rot is a severe fungal disease that has been spreading in wheat-growing areas in China since 2010. This study found that metconazole, a 14 alpha-demethylation inhibitor fungicide, effectively inhibits the growth and conidial germ tube elongation of Fusarium pseudograminearum, the predominant pathogen causing crown rot in China. Metconazole reduces toxin production and expression levels of toxin biosynthesis genes in F. pseudograminearum. Genome-wide transcriptional profiling revealed changes in gene expression related to ergosterol biosynthesis and ABC transporter-encoding genes in response to metconazole treatment. Greenhouse experiments demonstrated that seed treatment with metconazole significantly reduces crown rot occurrence in wheat.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Agronomy
Elsherbiny A. Elsherbiny, Dawood H. Dawood, Mahmoud F. Elsebai, Amira Mira, Mohamed A. Taher
Summary: The study found that the methanol extract of red onion peel has a good effect in preventing dry rot in potato tubers caused by Fusarium sambucinum. At a certain concentration, the methanol extract significantly inhibited fungal growth and spore germination, and effectively controlled dry rot in potato slices. In addition, the methanol extract increased the total phenolics and total flavonoid content in potato slices, reduced the leakage rate and MDA content, and enhanced the activity of PAL, PPO, CAT, and POD enzymes. The major compounds in the methanol extract were analyzed using HPLC-UV/DAD, QTOF, and NMR spectra.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ahmed Elbermawi, Mohamed Samir Darwish, Ahmed A. Zaki, Noha A. Abou-Zeid, Mohamed A. Taher, Ebtihal Khojah, Somaiah A. Bokhari, Amal F. Soliman
Summary: The study reveals the antioxidant, antidiabetic, and prebiotic activities of Guizotia abyssinica extract and its isolated compounds. Compound 10, myricetin-3-O-L-rhamnoside, exhibits the highest antioxidant capacity. It shows potential as a treatment for diabetes mellitus.
Article
Biotechnology & Applied Microbiology
Mohamed Samir Darwish, Longxin Qiu, Mohamed A. Taher, Ahmed A. Zaki, Noha A. Abou-Zeid, Dawood H. Dawood, Ola M. A. K. Shalabi, Ebtihal Khojah, Asmaa A. Elawady
Summary: Changes in the composition of phenolic compounds are associated with changes in the activities of antimicrobial, antitumor, and antioxidant properties of postbiotics. YCG-7 showed the highest antimicrobial activity and cytotoxicity, as well as effective scavenging of free radicals. The presence of Escherichia coli Nissle 1917 in YCG exhibited prebiotic activity.
FERMENTATION-BASEL
(2022)
Article
Chemistry, Analytical
Xinfa Cai, Meijuan Liang, Fei Ma, Sherif Ramzy Mohamed, Amira Abdel Goda, Dawood H. Dawood, Li Yu, Peiwu Li
Summary: A direct competitive nanozyme-linked immunosorbent assay based on MnO2 nanosheets as a nanozyme label was developed for highly sensitive determination of fumonisin B-1. The method showed a wide linear range, low detection limit, high accuracy, and good consistency with the reference method for screening FB1 in cereals.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
