Expansion microscopy: enabling single cell analysis in intact biological systems

Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion

(2018) David Unnersjö-Jess et al.   KIDNEY INTERNATIONAL

A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing

(2018) Tatsuya C. Murakami et al.   NATURE NEUROSCIENCE

Plasmonic nanoparticle-based expansion microscopy with surface-enhanced Raman and dark-field spectroscopic imaging

(2018) Camille G. Artur et al.   Biomedical Optics Express

Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy

(2018) Guiping Wang et al.   Scientific Reports

Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy

(2017) Tushar Deshpande et al.   GLIA

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy

(2017) Yongxin Zhao et al.   NATURE BIOTECHNOLOGY

Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation

(2017) Justin Decarreau et al.   NATURE CELL BIOLOGY

Iterative expansion microscopy

(2017) Jae-Byum Chang et al.   NATURE METHODS

Neuronal cell-type classification: challenges, opportunities and the path forward

(2017) Hongkui Zeng et al.   NATURE REVIEWS NEUROSCIENCE

Superresolution expansion microscopy reveals the three-dimensional organization of theDrosophilasynaptonemal complex

(2017) Cori K. Cahoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion microscopy of zebrafish for neuroscience and developmental biology studies

(2017) Limor Freifeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis

(2017) Roberto Villaseñor et al.   Cell Reports

The Human Cell Atlas

(2017) Aviv Regev et al.   eLife

Single-cell gene expression profiling and cell state dynamics: collecting data, correlating data points and connecting the dots

(2016) Carsten Marr et al.   CURRENT OPINION IN BIOTECHNOLOGY

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

(2016) Paul W Tillberg et al.   NATURE BIOTECHNOLOGY

Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues

(2016) Taeyun Ku et al.   NATURE BIOTECHNOLOGY

Expansion microscopy with conventional antibodies and fluorescent proteins

(2016) Tyler J Chozinski et al.   NATURE METHODS

Nanoscale imaging of RNA with expansion microscopy

(2016) Fei Chen et al.   NATURE METHODS

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs

(2016) Kenneth S. Kosik   NEURON

In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus

(2016) Sheel Shah et al.   NEURON

smiFISH and FISH-quant – a flexible single RNA detection approach with super-resolution capability

(2016) Nikolay Tsanov et al.   NUCLEIC ACIDS RESEARCH

Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons

(2016) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing

(2016) Jeffrey R. Moffitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications

(2016) Yu Shrike Zhang et al.   Scientific Reports

Hedgehog signaling regulates gene expression in planarian glia

(2016) Irving E Wang et al.   eLife

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

(2015) Evan Murray et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Defining cell types and states with single-cell genomics

(2015) Cole Trapnell   GENOME RESEARCH

Expansion microscopy

(2015) F. Chen et al.   SCIENCE

Single-molecule insights into mRNA dynamics in neurons

(2015) Adina R. Buxbaum et al.   TRENDS IN CELL BIOLOGY

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Spatially resolved transcriptomics and beyond

(2014) Nicola Crosetto et al.   NATURE REVIEWS GENETICS

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Super-resolution microscopy of the immunological synapse

(2013) Jérémie Rossy et al.   CURRENT OPINION IN IMMUNOLOGY

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

In situ sequencing for RNA analysis in preserved tissue and cells

(2013) Rongqin Ke et al.   NATURE METHODS

The promise of single-cell sequencing

(2013) James Eberwine et al.   NATURE METHODS

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Multiple models to capture the variability in biological neurons and networks

(2011) Eve Marder et al.   NATURE NEUROSCIENCE

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY