Article
Microbiology
Ganghee Chae, Yea Eun Park, Yong Pil Chong, Hyun Joo Lee, Tae Sun Shim, Kyung-Wook Jo
Summary: This study investigated the treatment outcomes of cavitary nodular bronchiectatic (C-NB)-type Mycobacterium avium complex (MAC) pulmonary disease (PD) and found that treatment with guideline-based therapy (GBT) resulted in significantly higher culture conversion rates for C-NB type compared to fibrocavitary (FC) type. Furthermore, it was observed that oral antibiotics alone could effectively treat C-NB type.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Bahareh Hajikhani, Mohammad Javad Nasiri, Brian C. Adkinson, Taher Azimi, Farima Khalili, Mehdi Goudarzi, Masoud Dadashi, Mukunthan Murthi, Mehdi Mirsaeidi
Summary: The study compared the efficacy of Rifampin and Rifabutin in treating MAC, and found similar treatment success rates between the two. Double-blind clinical trial studies are recommended to determine the exact preference of each of these drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo-Guen Kim, Byung Woo Jhun, Hojoong Kim, O. Jung Kwon
Summary: This study analyzed the outcomes of 992 MAC-PD patients and found that patients with mild disease had higher culture conversion rates. The study also showed that daily and intermittent therapy yielded similar culture conversion rates for mild disease.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Chia-Ling Chang, Chong-Jen Yu, Po-Ren Hsueh, Jung-Yien Chien
Summary: This retrospective study in Taiwan examined the treatment responses and outcomes in patients with Mycobacterium avium-intracellulare complex pulmonary disease (MAC-PD). The study found that patients treated with a macrolide + rifamycin + ethambutol (M + R + EMB) combination had a higher microbiological cure rate. Additionally, patients with persistently positive sputum smears after 6 months of treatment had a lower microbiological cure rate.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Chia-Ling Chang, Chong-Jen Yu, Po-Ren Hsueh, Jung-Yien Chien
Summary: In this study, patients with MAC-PD treated with a macrolide + rifamycin + ethambutol (M + R + EMB)-based regimen had a higher microbiological cure rate than those treated with other regimens. After 6 months of treatment, patients with persistently positive sputum smears had a lower microbiological cure rate than those with negative sputum smears. Among patients with microbiological cure, the median time from sputum culture conversion to treatment completion was 221.5 days (range, 0-483), and the 1-year relapse rate was 17%.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Bahareh Hajikhani, Mohammad Javad Nasiri, Sareh Sadat Hosseini, Farima Khalili, Mohammadmahdi Karimi-Yazdi, Ali Hematian, Neda Yousefi Nojookambari, Mehdi Goudarzi, Masoud Dadashi, Mehid Mirsaeidi
Summary: The in vitro resistance rates of CFZ in clinical isolates of MAC and MABS were 9.0% and 16.0% respectively, with no evidence of publication bias.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Medicine, General & Internal
Mohammad Javad Nasiri, Tess Calcagno, Sareh Sadat Hosseini, Ali Hematian, Neda Youse Fi Nojookambari, Mohammadmahdi Karimi-Yazdi, Mehdi Mirsaeidi
Summary: Treatment with clofazimine for MAC showed a moderate success rate, with slightly higher response rates in HIV patients with disseminated infection.
FRONTIERS IN MEDICINE
(2021)
Review
Microbiology
Nobuhiro Fujishima, Kosaku Komiya, Mari Yamasue, Kazufumi Hiramatsu, Jun-ichi Kadota
Summary: This systematic review investigated the factors associated with mortality among patients with Mycobacterium avium complex lung disease. The results suggested that advanced age, male sex, low body mass index, hypoalbuminemia, and cavity are likely to be the common risk factors for all-cause mortality among these patients, highlighting the need for careful monitoring.
Review
Infectious Diseases
Nils Wetzstein, Thomas A. Kohl, Margo Diricks, Silvia Mas-Peiro, Tomas Holubec, Johanna Kessel, Christiana Graf, Benjamin Koch, Eva Herrmann, Maria J. G. T. Vehreschild, Michael Hogardt, Stefan Niemann, Christoph Stephan, Thomas A. Wichelhaus
Summary: This study aimed to investigate the clinical characteristics and outcome of HCU-associated Mycobacterium chimaera infections. The study found that these infections were characterized by high morbidity and mortality, as well as challenges in diagnosis and treatment. Reoperation was associated with better survival.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Surgery
Joachim N. Meuli, Martino Guiotto, Jolanda Elmers, Lucia Mazzolai, Pietro G. di Summa
Summary: Microsurgical treatments such as lymphovenous anastomosis and vascularized lymph node transfers have been found to be effective in reducing the severity of lymphedema. However, there is a lack of standardized evaluation methods and varying outcomes reported in different studies. Future research should focus on standardizing staging methods, outcome measurements, and reporting to ensure comparability and pooling of results.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Microbiology
Seong Min Kim, Yong Pil Chong, Hyun Joo Lee, Tae Sun Shim, Kyung-Wook Jo
Summary: In the treatment of cavitary MAC pulmonary disease, the inclusion of streptomycin or amikacin in the treatment regimen leads to similar rates of culture conversion. The choice of medication can be based on physician or patient preference for treatment duration of at least 1 year.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Temitope C. Ekundayo, Ayodeji O. Falade, Bright E. Igere, Chidozie D. Iwu, Mary A. Adewoyin, Tosin A. Olasehinde, Oluwatosin A. Ijabadeniyi
Summary: The study reveals a significant association between MAP and type 1 diabetes mellitus (T1DM), highlighting the potential impact of MAP prevention and environmental control on T1DM management. However, the relationship between MAP and type 2 diabetes mellitus (T2DM) remains uncertain and requires further data to determine their association.
SCIENTIFIC REPORTS
(2022)
Review
Surgery
Thomas J. O'Malley, Diana C. Jimenez, Abhiraj Saxena, Matthew P. Weber, Louis E. Samuels, John W. Entwistle, T. Sloane Guy, H. Todd Massey, Rohinton J. Morris, Vakhtang Tchantchaleishvili
Summary: A systematic review and meta-analysis were conducted to study the perioperative details and long-term outcomes of surgical treatment in patients with carcinoid heart disease. The study revealed that patients are generally older, with a higher proportion of males, and the main post-operative issues include heart failure and valve regurgitation, with a relatively high survival rate after surgery.
Article
Clinical Neurology
Temitope C. Ekundayo, Tosin A. Olasehinde, Ayodeji O. Falade, Mary A. Adewoyin, Chidozie D. Iwu, Bright E. Igere, Oluwatosin A. Ijabadeniyi
Summary: The present study used meta-analysis to identify a significant association between Mycobacterium avium subsp. paratuberculosis (MAP) and multiple sclerosis (MS). This suggests that MAP may be an important environmental factor in the development of MS. Early screening for MAP in MS cases may aid in management and treatment. Future research should focus on the role of MAP in the severity of MS and address global data gaps and low disease surveillance.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Jay Peters, Diego Jose Maselli, Mandeep A. Mangat, Jacqueline. J. Coalson, Cecilia Hinojosa, Luis Giavedoni, Barbara. A. Brown-Elliott, Edward Chan, David Griffith, Selvakumar Subbian
Summary: This study aimed to assess the susceptibility, immunologic and histopathologic responses of common marmosets to M. avium complex pulmonary infection. The results showed that the marmosets developed signs of pulmonary tuberculosis infection, immunologic and histopathologic abnormalities, and had a chronic course.