Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy

Anti-Inducible Costimulator Monoclonal Antibody Treatment of Canine Chronic Graft-versus-Host Disease

(2018) Scott S. Graves et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

TFH-derived dopamine accelerates productive synapses in germinal centres

(2017) Ilenia Papa et al.   NATURE

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of ICOS+ T cell depletion via afucosylated monoclonal antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring

(2017) Simone M. Nicholson et al.   REPRODUCTIVE TOXICOLOGY

The Dual Role of Treg in Cancer

(2017) M. Frydrychowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Emerging targets in cancer immunotherapy

(2017) Samantha Burugu et al.   SEMINARS IN CANCER BIOLOGY

Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer

(2017) Lijun Mo et al.   VACCINE

Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

(2017) Ruishu Deng et al.   Nature Communications

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

(2017) Dmitriy Zamarin et al.   Nature Communications

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

(2017) Stephanie Downs-Canner et al.   Nature Communications

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

(2017) Aude Burlion et al.   Frontiers in Immunology

14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency

(2017) Johanna Schepp et al.   Frontiers in Immunology

Development of T follicular helper cells and their role in disease and immune system

(2016) Sadegh Eivazi et al.   BIOMEDICINE & PHARMACOTHERAPY

Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy

(2016) K.-S. Le et al.   CANCER RESEARCH

ICOS Promotes the Function of CD4+Effector T Cells during Anti-OX40–Mediated Tumor Rejection

(2016) Todd C. Metzger et al.   CANCER RESEARCH

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

(2016) Chad Tang et al.   CLINICAL CANCER RESEARCH

Immune checkpoint inhibitors: a patent review (2010-2015)

(2016) Matthieu Collin   EXPERT OPINION ON THERAPEUTIC PATENTS

Functional exhaustion of CD4+T cells induced by co-stimulatory signals from myeloid leukaemia cells

(2016) Didem Ozkazanc et al.   IMMUNOLOGY

ICOS+Foxp3+TILs in gastric cancer are prognostic markers and effector regulatory T cells associated withHelicobacter pylori

(2016) Hirotsugu Nagase et al.   INTERNATIONAL JOURNAL OF CANCER

ICOS Co-Stimulation: Friend or Foe?

(2016) Daniel J. Wikenheiser et al.   Frontiers in Immunology

The clinical impact of ICOS signal in colorectal cancer patients

(2016) Yan Zhang et al.   OncoImmunology

Expression of T-Follicular Helper Markers in Sequential Biopsies of Progressive Mycosis Fungoides and Other Primary Cutaneous T-Cell Lymphomas

(2015) Francesca M. Bosisio et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

A three-signal model of T-cell lymphoma pathogenesis

(2015) Ryan A. Wilcox   AMERICAN JOURNAL OF HEMATOLOGY

Downregulation of myeloma-induced ICOS-L and regulatory T cell generation by lenalidomide and dexamethasone therapy

(2015) Gina B. Scott et al.   CELLULAR IMMUNOLOGY

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

(2015) Erica L. Stone et al.   IMMUNITY

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS

(2015) Miguel F. Sanmamed et al.   SEMINARS IN ONCOLOGY

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

(2015) Alvin Pratama et al.   Nature Communications

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment

(2014) Matthew J. Ahearne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pattern Recognition Receptor Signaling in Human Dendritic Cells is Enhanced by ICOS Ligand and Modulated by the Crohn’s Disease ICOSLG Risk Allele

(2014) Matija Hedl et al.   IMMUNITY

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

(2014) Xiaozhou Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy

(2014) Joanne Leung et al.   Immune Network

Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells

(2013) P. Greaves et al.   BLOOD

Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer

(2013) Xiao-Mei Huang et al.   CANCER SCIENCE

CD30-positive peripheral T-cell lymphomas share molecular and phenotypic features

(2013) B. Bisig et al.   HAEMATOLOGICA

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

CD4 T Cells Require ICOS-Mediated PI3K Signaling to Increase T-Bet Expression in the Setting of Anti-CTLA-4 Therapy

(2013) H. Chen et al.   Cancer Immunology Research

Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy

(2013) D. Ng Tang et al.   Cancer Immunology Research

ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+T cells by plasmacytoid dendritic cells

(2013) Julien Faget et al.   OncoImmunology

The role of B7 family molecules in hematologic malignancy

(2012) P. Greaves et al.   BLOOD

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

(2012) J. Faget et al.   CANCER RESEARCH

Targeting regulatory T cells

(2012) Christine Ménétrier-Caux et al.   Targeted Oncology

Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression

(2012) Richard A. Peterson   TOXICOLOGIC PATHOLOGY

Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

(2011) Q. Zhang et al.   BLOOD

The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti-CTLA-4 Therapy

(2011) T. Fu et al.   CANCER RESEARCH

Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting

(2010) Geoffrey Y. Ku et al.   CANCER

Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

(2010) N. Martin-Orozco et al.   CANCER RESEARCH

Tremelimumab in Combination with Exemestane in Patients with Advanced Breast Cancer and Treatment-Associated Modulation of Inducible Costimulator Expression on Patient T Cells

(2010) R. H. Vonderheide et al.   CLINICAL CANCER RESEARCH

Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial

(2010) B. C. Carthon et al.   CLINICAL CANCER RESEARCH

The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation

(2010) T. Marafioti et al.   HAEMATOLOGICA

Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients

(2010) Hyunji Lee et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells

(2009) Gusheng Tang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage

(2009) T. Yamashita et al.   CLINICAL CANCER RESEARCH

Only Therapeutic ICOS:ICOSL Blockade Alleviates Acute Graft versus Host Disease

(2009) A. Mollweide et al.   KLINISCHE PADIATRIE

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

(2009) M. Gigoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

(2009) D. Bogunovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effector Functions of Donor-Reactive CD8 Memory T Cells Are Dependent on ICOS Induced During Division in Cardiac Grafts

(2008) A. D. Schenk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T cells and treatment of cancer

(2008) Tyler J Curiel   CURRENT OPINION IN IMMUNOLOGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

(2008) C. I. Liakou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA