Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Loss of T Follicular Helper Cells in the Peripheral Blood of Patients with Chronic Graft-versus-Host Disease

(2016) David A. Knorr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice

(2016) H. Jin et al.   BLOOD

Circulating T follicular helper cells with increased function during chronic graft-versus-host disease

(2016) E. Forcade et al.   BLOOD

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion

(2016) Roberto Tinoco et al.   IMMUNITY

CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima

(2016) Mark Roufaiel et al.   NATURE IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells

(2016) Dana Vu Van et al.   Nature Communications

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

(2015) Huimin Geng et al.   CANCER CELL

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation

(2015) Dan Lu et al.   NATURE IMMUNOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

How we treat chronic graft-versus-host disease

(2014) M. E. D. Flowers et al.   BLOOD

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

(2014) R. Flynn et al.   BLOOD

Current issues in chronic graft-versus-host disease

(2014) G. Socie et al.   BLOOD

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

(2014) Jason A. Dubovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection

(2014) Peiyuan Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B7H1/CD80 Interaction Augments PD-1–Dependent T Cell Apoptosis and Ameliorates Graft-versus-Host Disease

(2014) Ruishu Deng et al.   JOURNAL OF IMMUNOLOGY

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

(2014) Haikun Wang et al.   NATURE IMMUNOLOGY

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

(2014) V. M. Liarski et al.   Science Translational Medicine

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

(2014) Saul J. Priceman et al.   Cell Reports

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

(2013) Krisztina Szabo et al.   CLINICAL IMMUNOLOGY

T-cell subsets in the germinal center

(2013) Roybel R. Ramiscal et al.   IMMUNOLOGICAL REVIEWS

Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

(2013) T. Wu et al.   JOURNAL OF IMMUNOLOGY

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

(2012) Arian Laurence et al.   IMMUNITY

T cells that promote B-Cell maturation in systemic autoimmunity

(2012) Jason S. Weinstein et al.   IMMUNOLOGICAL REVIEWS

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

(2012) Tomohiro Kaji et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4+ T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease

(2012) J. S. Young et al.   JOURNAL OF IMMUNOLOGY

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

Roles of CD28, CTLA4, and Inducible Costimulator in Acute Graft-versus-Host Disease in Mice

(2011) Jun Li et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Tocilizumab for the Treatment of Steroid Refractory Graft-versus-Host Disease

(2011) William R. Drobyski et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

(2011) M. Srinivasan et al.   BLOOD

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of B7-H1 Expression by Recipient Parenchymal Cells Leads to Expansion of Infiltrating Donor CD8+ T Cells and Persistence of Graft-Versus-Host Disease

(2011) X. Li et al.   JOURNAL OF IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Alloimmune Response Results in Expansion of Autoreactive Donor CD4+ T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease

(2010) D. Zhao et al.   JOURNAL OF IMMUNOLOGY

Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD

(2010) Junya Fujimura et al.   PEDIATRIC TRANSPLANTATION

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

(2009) Il-Kang Na et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 Signaling in CD4+ T Cells Is Critical for the Pathogenesis of Chronic Sclerodermatous Graft-Versus-Host Disease in a Murine Model

(2009) V. Radojcic et al.   JOURNAL OF IMMUNOLOGY

Only Therapeutic ICOS:ICOSL Blockade Alleviates Acute Graft versus Host Disease

(2009) A. Mollweide et al.   KLINISCHE PADIATRIE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease

(2008) D. Zhao et al.   BLOOD

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE