Targeting regulatory T cells

Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF -Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

(2014) M.-L. Chen et al.   JOURNAL OF IMMUNOLOGY

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

CD69+CD4+CD25- T Cells, a New Subset of Regulatory T Cells, Suppress T Cell Proliferation through Membrane-Bound TGF- 1

(2014) Y. Han et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

(2014) E. Bardel et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

(2011) S. I. Labidi-Galy et al.   CANCER RESEARCH

Early Detection of Tumor Cells by Innate Immune Cells Leads to Treg Recruitment through CCL22 Production by Tumor Cells

(2011) J. Faget et al.   CANCER RESEARCH

Regulation of T cell activation by TLR ligands

(2011) Hans-Heinrich Oberg et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance

(2011) V. Chaturvedi et al.   JOURNAL OF IMMUNOLOGY

TLR1/TLR2 Agonist Induces Tumor Regression by Reciprocal Modulation of Effector and Regulatory T Cells

(2011) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma

(2010) Francesco Liotta et al.   BJU INTERNATIONAL

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

(2010) E. Martin-Gayo et al.   BLOOD

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

(2010) J. Mitsui et al.   CLINICAL CANCER RESEARCH

Modulation of Lymphocyte Regulation for Cancer Therapy: A Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma

(2010) C. Ralph et al.   CLINICAL CANCER RESEARCH

Androgen Deprivation Boosts Prostatic Infiltration of Cytotoxic and Regulatory T Lymphocytes and Has No Effect on Disease-Free Survival in Prostate Cancer Patients

(2010) Carlo Sorrentino et al.   CLINICAL CANCER RESEARCH

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma

(2010) Kazuhito Yamamoto et al.   JOURNAL OF CLINICAL ONCOLOGY

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

(2010) C. Camisaschi et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

(2010) Paolo A. Ascierto et al.   SEMINARS IN ONCOLOGY

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Clinical Use of Anti-CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

(2009) Andrew J. Rech et al.   Annals of the New York Academy of Sciences

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease

(2009) I. Kryczek et al.   CANCER RESEARCH

The CD4+ T-Cell Response of Melanoma Patients to a MAGE-A3 Peptide Vaccine Involves Potential Regulatory T Cells

(2009) V. Francois et al.   CANCER RESEARCH

Differences in Tumor Regulatory T-Cell Localization and Activation Status Impact Patient Outcome

(2009) C. Menetrier-Caux et al.   CANCER RESEARCH

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Immunomodulation of FOXP3+ Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients

(2009) D. Generali et al.   CLINICAL CANCER RESEARCH

The Tregs' world according to GARP

(2009) Manuela Battaglia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

(2009) Frank A. Sinicrope et al.   GASTROENTEROLOGY

A Novel Splice Variant of FR4 Predominantly Expressed in CD4+CD25+Regulatory T Cells#

(2009) Zhengcai Jia et al.   IMMUNOLOGICAL INVESTIGATIONS

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

Pretreatment frequency of circulating IL-17+CD4+T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients

(2009) Evelyna Derhovanessian et al.   INTERNATIONAL JOURNAL OF CANCER

OX40 costimulation can abrogate Foxp3+regulatory T cell-mediated suppression of antitumor immunity

(2009) Naomi Kitamura et al.   INTERNATIONAL JOURNAL OF CANCER

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism

(2009) Sabine Ring et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Perspectives on Regulatory T Cell Therapies

(2009) Michael Probst-Kepper et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

(2008) B. Kavanagh et al.   BLOOD

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

(2008) Robbert G. van der Most et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

(2008) J. Yokokawa et al.   CLINICAL CANCER RESEARCH

Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy

(2008) Lei Zhang et al.   CLINICAL IMMUNOLOGY

Regulatory T cells and treatment of cancer

(2008) Tyler J Curiel   CURRENT OPINION IN IMMUNOLOGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

Three Phase II Cytokine Working Group Trials of gp100 (210M) Peptide Plus High-Dose Interleukin-2 in Patients With HLA-A2–Positive Advanced Melanoma

(2008) Jeffrey A. Sosman et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma

(2008) Kennosuke Karube et al.   MODERN PATHOLOGY

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

(2008) Rui Wang et al.   PLoS One

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

(2008) J. Bayry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE