The development of biological therapies for neurological diseases: moving on from previous failures

Autologous haematopoietic stem cell transplantation for neurological diseases

(2017) Joachim Burman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Alzheimer Disease

(2017) Richard J. Caselli et al.   MAYO CLINIC PROCEEDINGS

Autologous hematopoietic stem cell transplantation in multiple sclerosis

(2017) Maria Pia Sormani et al.   NEUROLOGY

Antibody therapies in CNS diseases

(2017) Per-Ola Freskgård et al.   NEUROPHARMACOLOGY

miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors

(2017) Yael Gothelf et al.   Stem Cell Research & Therapy

Transporters as Drug Targets in Neurological Diseases

(2016) H Qosa et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities

(2016) KM Morrissey et al.   CTS-Clinical and Translational Science

Stem cells therapy for ALS

(2016) Letizia Mazzini et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

(2016) Franck Patin et al.   Neurotherapeutics

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

(2015) Jason M. Lajoie et al.   Annual Review of Pharmacology and Toxicology

Ofatumumab Exhibits Enhanced In Vitro and In Vivo Activity Compared to Rituximab in Preclinical Models of Mantle Cell Lymphoma

(2015) M. J. Barth et al.   CLINICAL CANCER RESEARCH

Gene therapy for neurological disorders

(2015) Chi-Jing Choong et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer’s Disease and Other Tauopathies

(2015) Sulana K. Schroeder et al.   Journal of Neuroimmune Pharmacology

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Regenerative medicine: Current therapies and future directions

(2015) Angelo S. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's amyloid theory gets modest boost

(2015) E. Underwood   SCIENCE

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

State of the art paper Tumor necrosis factor inhibitors – state of knowledge

(2015) Krzysztof Lis et al.   Archives of Medical Science

Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis—A Pilot Study

(2015) André Maier et al.   PLoS One

Targeting CNS Transporters for Treatment of Neurodegenerative Diseases

(2014) Gabriele Jedlitschky et al.   CURRENT PHARMACEUTICAL DESIGN

Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis

(2014) V. Bros-Facer et al.   HUMAN MOLECULAR GENETICS

Nanoscale drug delivery systems and the blood–brain barrier

(2014) Igor Khalin et al.   International Journal of Nanomedicine

Amyloid-ß-directed immunotherapy for Alzheimer's disease

(2014) L. Lannfelt et al.   JOURNAL OF INTERNAL MEDICINE

Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: A phase 2 study

(2014) P. S. Sorensen et al.   NEUROLOGY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Phase 3 Trials of Solanezumab and Bapineuzumab for Alzheimer's Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Pharmacokinetic, and Functional Effects of the Nogo-A Monoclonal Antibody in Amyotrophic Lateral Sclerosis: A Randomized, First-In-Human Clinical Trial

(2014) Vincent Meininger et al.   PLoS One

Randomized Placebo-Controlled Phase II Trial of Autologous Mesenchymal Stem Cells in Multiple Sclerosis

(2014) Sara Llufriu et al.   PLoS One

Modulation of β-amyloid by a single dose of GSK933776 in patients with mild Alzheimer’s disease: a phase I study

(2014) Thomas Leyhe et al.   Alzheimers Research & Therapy

Biological therapies: a long way on from Jenner

(2013) Albert Ferro et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cell-based therapy for ischemic stroke

(2013) Jing Zhang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A Double-Blind Placebo-Controlled Clinical Evaluation of Multistem for the Treatment of Ischemic Stroke

(2013) David C. Hess et al.   International Journal of Stroke

Pharmacokinetics and Brain Uptake of an IgG-TNF Decoy Receptor Fusion Protein Following Intravenous, Intraperitoneal, and Subcutaneous Administration in Mice

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Therapeutic Antibodies in Stroke

(2013) Chye Yun Yu et al.   Translational Stroke Research

Clinical pharmacology considerations in biologics development

(2012) Liang Zhao et al.   ACTA PHARMACOLOGICA SINICA

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A 

(2012) O. Adolfsson et al.   JOURNAL OF NEUROSCIENCE

Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial

(2012) Jeffrey A Cohen et al.   LANCET

Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial

(2012) Alasdair J Coles et al.   LANCET

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies

(2012) Shubhada N. Joshi et al.   mAbs

Expanded indications for stroke thrombolysis—what next?

(2012) Geoffrey A. Donnan et al.   Nature Reviews Neurology

Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

(2012) Miguel Blanquer et al.   STEM CELLS

Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke

(2012) Francisco Moniche et al.   STROKE

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

Vaccination for Parkinson's disease

(2011) A. Schneeberger et al.   PARKINSONISM & RELATED DISORDERS

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study

(2010) Bassem Yamout et al.   JOURNAL OF NEUROIMMUNOLOGY

Receptor-Mediated Abeta Amyloid Antibody Targeting to Alzheimer’s Disease Mouse Brain

(2010) Qing-Hui Zhou et al.   MOLECULAR PHARMACEUTICS

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

(2009) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

P-gp Transporter and its Role in Neurodegenerative Diseases

(2009) Simona Rapposelli et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY

Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis

(2008) Felicia Yu Hsuan Teng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

(2008) E. J. Sorenson et al.   NEUROLOGY