Article
Biochemistry & Molecular Biology
Esam O. Kamel, Wail M. Gad-Elrab, Mohammed A. Ahmed, Zuhair M. Mohammedsaleh, Emad H. M. Hassanein, Fares E. M. Ali
Summary: Candesartan can attenuate Cd-induced hepatorenal intoxication through modulation of multiple signaling pathways, including antioxidant, anti-inflammatory, and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Xue-Yi Wu, Tian Wang, Hui-Xin Hu, Kan Zhang, Yu Zhao, Bao-Bing Zhao, Hong-Xiang Lou, Xiao-Ning Wang, Tao Shen
Summary: Rhamnazin (RN) is a flavonol compound extracted from Physalis alkekengi L. var. franchetii, which has been used in traditional Chinese medicine for treating pulmonary diseases. This study reveals that RN activates the Nrf2 pathway and effectively alleviates oxidative stress and inflammation in pulmonary disorders. The therapeutic effects of RN are associated with inhibition of NF-κB and promotion of cell autophagy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chun Hua Piao, Yanjing Fan, Thi Van Nguyen, Hee Soon Shin, Hyoung Tae Kim, Chang Ho Song, Ok Hee Chai
Summary: This study found that PM2.5 exposure may exacerbate allergic rhinitis in mice by enhancing inflammatory cell expression and oxidative stress. Additionally, PM2.5 exposure could increase histopathological changes in nasal and lung tissues, while inhibiting the activity of the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dorthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Summary: NRF2 is a master transcription factor that regulates the expression of detoxifying and antioxidant genes. It plays a role in redox regulation, metabolism, inflammation/autoimmune disease, cancer, and radioresistance. Activation of NRF2 pathways by ionizing radiation is delayed and may be critical for immune transition and cellular survival.
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Pharmacology & Pharmacy
Ehsan Khaledi, Tayebeh Noori, Ahmad Mohammadi-Farani, Antoni Sureda, Ahmad Reza Dehpour, Hasan Yousefi-Manesh, Eduardo Sobarzo-Sanchez, Samira Shirooie
Summary: The study demonstrated that trifluoperazine (TF) can improve cuprizone-induced behavioral and histopathological changes in the prefrontal cortex of male C57BL/6 mice by reversing weight loss, motor deficits, and demyelination. TF administration also normalized the changes in oxidative stress markers and signaling pathways associated with cuprizone exposure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Zhu-Xia Tan, Lin Fu, Wen-Jing Wang, Ping Zhan, Hui Zhao, Hua Wang, De-Xiang Xu
Summary: The study revealed that elevated levels of serum and pulmonary CYR61 were associated with decreased pulmonary function indexes and increased levels of inflammatory cytokines in COPD patients. Inflammatory cytokines may mediate the relationship between CYR61 elevation and COPD progression.
FRONTIERS IN MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Biochemistry & Molecular Biology
Kailong Zhou, Dong Liu, Yesheng Jin, Wei Xia, Peng Zhang, Zhiqiang Zhou
Summary: The study found that oxymatrine (OMT) reduces the production of pro-inflammatory cytokines, degradation of extracellular matrix (ECM), and the progression of osteoarthritis (OA) by activating Nrf2 and inhibiting the NF-κB pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Nutrition & Dietetics
Mi-Sun Kim, Dong-Seon Kim, Heung Joo Yuk, Seung-Hyung Kim, Won-Kyung Yang, Geum Duck Park, Kyung Seok Kim, Woo Jung Ham, Yoon-Young Sung
Summary: The study investigated the effects of Siraitia grosvenorii extracts (SGE) on airway inflammation in a COPD mouse model and LPS-treated human bronchial epithelial cell line. SGE improved cell viability, inhibited inflammatory cytokine production, and attenuated MAPK-NF-kappa B signaling. In mice, SGE reduced immune cell infiltration, inhibited cytokine secretion, and alleviated mucus production. SGE also showed potential in improving expectoration. Overall, SGE is a potential herbal candidate for COPD therapy.
Article
Nutrition & Dietetics
Rasha Al-Hussan, Nawal A. Albadr, Ghedeir M. Alshammari, Soheir A. Almasri, Mohammed Abdo Yahya
Summary: This study investigated the effects of phloretamide on liver damage and steatosis in diabetic rats. The results showed that phloretamide improved insulin resistance, reduced blood glucose levels, and decreased hepatic lipid accumulation. It also exhibited antioxidant and anti-inflammatory properties.
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Changzhi Zhao, Congshu Xiao, Songqiao Feng, Jianxin Bai
Summary: In this study, we discovered a new approach to alleviate liver damage caused by severe septic shock by controlling a form of controlled cell death called ferroptosis. We found that artemisitene (ATT) significantly reduced liver damage and ferroptotic characteristics. Additionally, ATT reduced the expression of the nuclear factor-κB (NF-κB) subunit to reduce LPS-induced hepatic oxidative stress and inflammation, and upregulated the expression of the nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) and its downstream protein heme oxygenase 1 (HO-1).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Quanquan Song, Qin Bian, Tingting Liang, Yinghui Zhang, Kai Zhang
Summary: The study aimed to explore potential biomarkers and susceptible populations for tuberculosis, identifying 10 hub differentially expressed genes and constructing a regulatory network. Functional analysis revealed enrichment in interferon pathway and cytokine interactions, while the NFATC1-(miR145)-STAT1 regulatory pathway was highlighted as critical for TB. Immunoheterogeneity was found among TB patients, suggesting the pathway as a valuable target for prevention and treatment of tuberculosis.
Article
Endocrinology & Metabolism
Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang
Summary: This study found that the SLC24A2 gene may link type 2 diabetes (T2D) and cancer by influencing the ribosome function of islet beta cells and play different prognostic roles in different cancers.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Environmental Sciences
Rukun Chen, Kai Zhang, Xiaoguang Li, Jutang Li, Qixia Jiang
Summary: This study used data from Shanghai to explore the relationship between PM2.5 and its components and FMD. The results showed that as PM2.5 levels increased, endothelial function decreased. Black carbon was found to be the dominant factor, while sulphate, organic matter, and ammonium may also play significant roles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Review
Environmental Sciences
Attila Csaba Kondor, Anna Viktoria Vancsik, Laszlo Bauer, Lili Szabo, Zoltan Szalai, Gergely Jakab, Gabor Maasz, Marta Pedrosa, Maria Jose Sampaio, Ana Rita Lado Ribeiro
Summary: This review provides a critical overview of research on the removal efficiency of priority substances and compounds of emerging concern through bank filtration, discussing influencing factors and future challenges. The findings show that the efficiency of bank filtration is influenced by multiple factors and varies for different substances.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang
Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang
Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Naoto Ishiwaka, Koya Hashimoto, Masayoshi K. Hiraiwa, Francisco Sanchez-Bayo, Taku Kadoya, Daisuke Hayasaka
Summary: Systemic insecticides and rising temperatures have combined effects on the abundance of Odonata nymphs in paddy fields. The standalone effect of insecticide exposure decreased the Odonata community, while nymphs decreased synergistically with temperature rise in paddy water. However, the impacts of each stressor alone varied among species.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Marco Vecchiato, Carlo Barbante, Elena Barbaro, Francois Burgay, Warren R. L. Cairns, Alice Callegaro, David Cappelletti, Federico Dallo, Marianna D'Amico, Matteo Feltracco, Jean-Charles Gallet, Andrea Gambaro, Catherine Larose, Niccolo Maffezzoli, Mauro Mazzola, Ivan Sartorato, Federico Scoto, Clara Turetta, Massimiliano Varde, Zhiyong Xie, Andrea Spolaor
Summary: The Arctic region is facing contamination from long-range pollution and local human activities. Polycyclic Aromatic Hydrocarbons (PAHs) are used as environmental indicators for emission, transport, and deposition processes. Research conducted in the Arctic surface snow in Ny-Ålesund, Svalbard from October 2018 to May 2019 shows that long-range inputs of PAHs mainly occur in winter, while the most abundant analyte retene exhibits opposite seasonal trends.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Maoshui Zhuo, Zhijie Chen, Xiaoqing Liu, Wei Wei, Yansong Shen, Bing-Jie Ni
Summary: This paper discusses the application of three catalytic processes (photocatalysis, electrocatalysis, and biocatalysis) in the management of microplastic pollution, and introduces the efficiency and catalytic mechanisms of different catalysts. It also proposes the development prospects for sustainable management of microplastic pollution.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Shiyu Chen, Zhenzhen Shi, Qiang Zhang
Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Bangguo Wang, Lijing Wang, Wenxi Cen, Tao Lyu, Peter Jarvis, Yang Zhang, Yuanxun Zhang, Yinghui Han, Lei Wang, Gang Pan, Kaili Zhang, Wei Fan
Summary: This study investigates the feasibility and mechanisms of a chemical-free nanobubble-based AOP for treating organic micropollutants in water. The results show that the oxygen nanobubble AOP has a significantly higher removal efficiency compared to air and nitrogen nanobubbles. The treatment performance is not affected by pH and the presence of ions. Higher initial concentrations of the micropollutant lead to slower treatment processes, but similar removal performance is achieved in the end. The presence of organic matter reduces the removal rate of the micropollutant. The results have practical feasibility for water and wastewater treatment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yingmei Huang, Jicai Yi, Yao Huang, Songxiong Zhong, Bin Zhao, Jing Zhou, Yuxuan Wang, Yiwen Zhu, Yanhong Du, Fangbai Li
Summary: This study investigates the impact of biochar on methylmercury (MeHg) accumulation in rice. The results show that biochar reduces MeHg levels in paddy soils by decreasing bioavailable Hg and microbial Hg methylation. Additionally, biochar decreases the uptake and translocation of MeHg in rice plants, resulting in a reduction of MeHg accumulation in rice grains.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Nengde Zeng, Fei Huang, Jiani Du, Chenghao Huang, Qian Yang, Xinhua Zhan, Baoshan Xing
Summary: This study investigates the protein targets and protein-ligand interactions related to PAH contamination in crop xylem sap using computational tools. The results show that phenanthrene has a more pronounced effect on the xylem sap proteins of maize and wheat, with maize DEPs associated with lipid biosynthesis and wheat DEPs exhibiting an increase in ABC transporters. This study provides insights into the regulation and movement of PAHs within plant xylem.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinwei Chen, Hao Ma, Run Wang, Man Wang, Binbin Zhu, Yanqing Cong, Xiayue Zhu, Guoqin Wang, Yi Zhang
Summary: Co3O4/TiO2-NRs electrodes with excellent photoresponse were prepared via plasma-assisted modification of Co3O4 on TiO2. The combination of Co3O4 and TiO2 improved the light utilization efficiency and showed potential for degradation of pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Wenjing Ji, Liying Song, Jing Wang, Hongqing Song
Summary: This study conducted a life-cycle assessment to examine the correlation between natural gas consumption and carbon emissions in different end uses in China. The results showed that both natural gas consumption and life-cycle carbon emissions have been increasing since 2017. Significant variations in NG life-cycle carbon emissions were found across different provinces and sectors, highlighting the need for targeted efforts to reduce carbon emissions.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Youyi Chen, Boxuan Zhang, Pojun Zhang, Guogui Shi, Hao Liang, Wu Cai, Jingyu Gao, Sumin Zhuang, Kaiyin Luo, Jiaqi Zhu, Chaoxiang Chen, Kunyu Ma, Jinrong Chen, Chun Hu, Xueci Xing
Summary: The synergistic effects of trace sulfadiazine and cast-iron corrosion scales on the formation of disinfection by-products in drinking water distribution systems were investigated. The presence of magnetite resulted in increased concentrations of DBPs due to the higher microbial activity and enhanced microbial extracellular electron transport pathway. The study highlights the importance of considering trace antibiotics pollution and corrosion scales in water sources for DBP control.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang
Summary: This review summarizes the interactions, uptake, and transport of aluminum nanoparticles (Al-NPs) in plants, highlighting their negative effects on plant growth and development, as well as their potential to alter plant defense systems and gene expression.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yonglu Wang, Fengsong Zhang, Xiaoyong Liao, Xiao Yang, Guixiang Zhang, Liyun Zhang, Chaojun Wei, Pengge Shi, Jiongxin Wen, Xiaorong Ju, Can Xu, Yang Liu, Ying Lan
Summary: This study aims to explore the effects of thiencarbazone-methyl center dot isoxaflutole on soil microflora and the potential mitigation mechanisms to bacterial communities. It was found that increasing the application of thiencarbazone-methyl center dot isoxaflutole resulted in increased stress on soil bacterial community structure and diversity. Increasing soil pH was recognized as a key factor in improving the diversity and structure of soil microflora. Supplemental use of nitrapyrin or modified attapulgite can increase soil pH and improve bacterial diversity.
ENVIRONMENTAL POLLUTION
(2024)