Article
Cell Biology
Amira E. Abd El Aziz, Rabab Hamed Sayed, Nada A. Sallam, Nesrine S. El Sayed
Summary: In experimental mice, telmisartan and nifedipine demonstrated neuroprotective effects by improving locomotor activity and enhancing motor coordination, restoring myelin sheath and reducing oxidative stress and apoptosis, suggesting their potential therapeutic value in neurodegenerative diseases.
Article
Neurosciences
Mahdad Abdi, Parichehr Pasbakhsh, Maryam Shabani, Saied Nekoonam, Asie Sadeghi, Fardin Fathi, Morteza Abouzaripour, Wael Mohamed, Kazem Zibara, Iraj Ragerdi Kashani, Adib Zendedel
Summary: In summary, metformin treatment can reduce demyelination, reactive microgliosis, and pro-inflammatory gene expression while increasing AMPK activation and reducing NF-kappa B activity in a mouse model of MS induced by cuprizone. This suggests that metformin may offer potential therapeutic benefits for inflammatory neurodegenerative diseases like MS.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Heba R. Ghaiad, Mai A. Abd-Elmawla, Enas S. Gad, Kawkab A. Ahmed, Maha Abdelmonem
Summary: This study investigated the therapeutic effects of NaHS on cuprizone-induced multiple sclerosis (MS) and its potential mechanism involving the regulation of miR-146a/NF-κB/IL-1β axis. The results showed that NaHS treatment improved locomotor coordination and reduced demyelination, oxidative stress, and neuro-inflammation. Additionally, NaHS downregulated miR-146a expression and inhibited the activation of IRAK-1, NF-κB, IL-17, and IL-1β. These findings suggest that H2S-releasing compounds could be a promising approach for MS treatment.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Immunology
Ahmed Nadeem, Sheikh F. Ahmad, Naif O. Al-Harbi, Wedad Sarawi, Sabry M. Attia, Wael A. Alanazi, Khalid E. Ibrahim, Sary Alsanea, Saleh A. Alqarni, Ali S. Alfardan, Saleh A. Bakheet
Summary: Multiple sclerosis (MS) is a chronic autoimmune inflammation of the central nervous system (CNS), causing various clinical symptoms. This study found that the nutraceutical drug AKBA can improve the symptoms of MS by regulating the oxidant antioxidant balance and immune cell activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Adnan Khan, Bushra Shal, Ashraf Ullah Khan, Tehmina Bibi, Sara Zeeshan, Syeda Saniya Zahra, Phillip Crews, Ihsan ul Haq, Fakhar Ud Din, Hussaind Ali, Salman Khan
Summary: The study shows that Ajugarin-I (Aju-I) has neuroprotective properties in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) by regulating multiple signaling pathways. It reduces EAE-associated histopathological changes, inflammation, and cell apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Adnan Khan, Bushra Shal, Ashraf Ullah Khan, Tehmina Bibi, Salman ul Islam, Muhammad Waleed Baig, Ihsan ul Haq, Hussain Ali, Sajjad Ahmad, Salman Khan
Summary: The study demonstrated that WMT has significant neuroprotective potential in EAE by modulating Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, showing promising antioxidant and anti-neuroinflammatory properties both in vitro and in vivo models.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Ahmed E. Goda, Amr M. Elenany, Alaa E. Elsisi
Summary: Trifluoperazine demonstrates protective effects against doxorubicin-induced cardiotoxicity by alleviating heart failure, inflammation, and myofibril degeneration. Furthermore, trifluoperazine improves renal and hepatic impairments caused by doxorubicin, suggesting its potential in ameliorating organ toxicity.
Article
Biochemistry & Molecular Biology
Dorthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Summary: NRF2 is a master transcription factor that regulates the expression of detoxifying and antioxidant genes. It plays a role in redox regulation, metabolism, inflammation/autoimmune disease, cancer, and radioresistance. Activation of NRF2 pathways by ionizing radiation is delayed and may be critical for immune transition and cellular survival.
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Chemistry, Medicinal
Fatma H. Al-Awadhi, Emily F. Simon, Na Liu, Ranjala Ratnayake, Valerie J. Paul, Hendrik Luesch
Summary: This study identified monounsaturated fatty acids and their analogues with antioxidant and detoxification enzyme activation activities. Further investigations demonstrated the anti-inflammatory potential of one of the compounds, which may be involved in the regulation of inflammation-related diseases such as multiple sclerosis. Additionally, the widespread occurrence of these compounds in marine algal samples from different locations suggests their important ecological roles in marine ecosystems.
Article
Biochemistry & Molecular Biology
Amin Safa, Shahram Arsang-Jang, Mohammad Taheri, Mir Davood Omrani, Soudeh Ghafouri-Fard
Summary: The study analyzed the expression levels of specific lncRNAs and genes in the peripheral blood of MS patients and healthy controls, revealing the significant down-regulation of lncRNAs HNFIA-ASI and LINC00305 in the pathogenesis of MS.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Biochemistry & Molecular Biology
Kailong Zhou, Dong Liu, Yesheng Jin, Wei Xia, Peng Zhang, Zhiqiang Zhou
Summary: The study found that oxymatrine (OMT) reduces the production of pro-inflammatory cytokines, degradation of extracellular matrix (ECM), and the progression of osteoarthritis (OA) by activating Nrf2 and inhibiting the NF-κB pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Behavioral Sciences
Mohammad Amin Sadeghi, Sara Hemmati, Hasan Yousefi-Manesh, Saba Fekrvand, Laleh Foroutani, Ehsan Nassireslami, Mojtaba Yousefi Zoshk, Yasaman Hosseini, Ahmad Reza Dehpour, Mohsen Chamanara
Summary: Combining subchronic fluoxetine with selective nNOS inhibitor 7-nitroindazole accelerated the efficacy of fluoxetine in treating post-traumatic stress disorder, and hippocampal activity showed biphasic correlation with anxiety-related behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Gregorio Peron, Alice M. Lopez, Paulina Cabada-Aquirre, Karen D. Garay Buenrosto, Keila C. Ostos Mendoza, Gail B. Mahady, Veronique Seidel, Oksana Sytar, Niranjan Koirala, Roshani Gurung, Zenisha Acharya, Sundar Adhikari, Antoni Sureda, Miquel Martorell, Javad Sharifi-Rad
Summary: This article analyzes the antiviral and antibacterial capacity of phloroglucinols and their derivatives, indicating that these compounds have significant antimicrobial properties in vitro. However, the absence of in vivo studies and limited information on their mechanisms of action hinder their therapeutic use, requiring further research.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tayebeh Noori, Antoni Sureda, Samira Shirooie
Summary: Diabetes mellitus is a common and complex problem with significant socio-economic implications. It is caused by defects in insulin secretion or insulin resistance. Chronic hyperglycemia leads to various complications such as nephropathy, retinopathy, and cardiovascular disease. Traditional herbal medicine plays a significant role in diabetes treatment.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Environmental Sciences
Maria Febrer-Serra, Nil Lassnig, Victor Colomar, Gabriela Pico, Silvia Tejada, Antoni Sureda, Samuel Pinya
Summary: Stressful situations lead to an increase in reactive oxygen species, while the introduction of new potential predators induces physiological stress in native fauna. This study found that the moorish gecko exhibited behavioral responses and changes in oxidative stress biomarkers when exposed to the invasive predator horseshoe whip snake, indicating its ability to recognize and adapt to the snake.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Ecology
Marc Gost, Samuel Pinya, Antoni Sureda, Silvia Tejada, Pere Ferriol
Summary: The adaptation of sponges to freshwater environments was a major event in their evolutionary history. This study revealed that the growth capacity of the freshwater sponge Ephydatia fluviatilis is positively associated with high alkalinity values and affected by light exposure. These findings explain the greater distribution of this species in alkaline environments and emphasize the importance of symbiosis in E. fluviatilis.
Article
Pharmacology & Pharmacy
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Mohammad Sheibani, Seyed Mohammad Tavangar, Sara Hemmati, Mohammad Amin Sadeghi, Hassan Akbarniakhaky, Zohreh Mohammadi, Laleh Foroutani, Ahmad Reza Dehpour
Summary: English summary: The study investigates the effects of spermidine on oxidative stress markers and pain threshold in a rat model of chronic constriction injury. The findings suggest that spermidine treatment can alleviate neuropathic pain by reducing oxidative stress and improving pathological changes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour
Summary: Itching is an unpleasant sensation on the skin that affects the quality of life. Bromhexine, derived from Adhatoda vasica, has been found to alleviate acute itch by inhibiting TMPRSS2 and reducing KP activation. Administering 1-Methyl Tryptophan, an IDO inhibitor, also reduces itching. The combined use of bromhexine and 1-MT results in synergistic antipruritic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
Summary: In this study, it was found that sumatriptan has protective effects against mesenteric ischemia and the inhibition of the kynurenine pathway may be involved in this process. Therefore, sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.
PHARMACOLOGICAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Miguel D. Ferrer, Clara Reynes, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Miguel Casares, Cristina Gomez, Lucia Ugarriza, Josep A. Tur, Antoni Sureda, Antoni Pons
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic fat. This study investigated the plasma levels of oxylipins, free polyunsaturated fatty acids (PUFA), and markers of lipid peroxidation in NAFLD patients. The results showed that severe NAFLD patients had higher levels of oxylipins, saturated oxylipins, and free PUFA, suggesting an association between inflammation, fatty acid oxidation dysregulation, and NAFLD progression.
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Estefania Toledo, Isabel Cornejo-Pareja, Itziar Abete, Antoni Sureda, Maira Bes-Rastrollo, J. Alfredo Martinez, Francisco J. Tinahones, Josep A. Tur, Tany E. Garciduenas-Fimbres, Francisco Paris-Palleja, Albert Goday, Nuria Goni-Ruiz, Jordi Salas-Salvado, Nancy Babio
Summary: The consumption of ultra-processed food (UPF) is associated with a decline in kidney function, particularly among older adults. Therefore, reducing the intake of UPF is important for maintaining kidney function.
CLINICAL NUTRITION
(2023)
Review
Surgery
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: The incorporation of skin flaps in wound closure management has shown promise in achieving desirable cosmetic outcomes. However, skin flaps are prone to complications, such as ischemia-reperfusion injury (IRI), due to various factors. Numerous approaches have been attempted to enhance skin flap survival, including pre/post-conditioning with surgical and pharmacological methods. These approaches utilize cellular and molecular mechanisms to reduce inflammation, promote angiogenesis, induce apoptosis and autophagy. The emerging role of stem cells in improving skin flap viability has led to the development of more translational methods. This review aims to provide current evidence on these approaches.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Mina Gholami, A. Wallace Hayes, Hamidreza Jamaati, Antoni Sureda, Majid Motaghinejad
Summary: This study investigated the neurotoxicity of tramadol and found that it activates apoptosis and autophagy through modulation of TNF-α or IL-1β/JNK/Bcl-2/Beclin1 and Bcl-2/Bax signaling pathways, as well as dysfunction of mitochondrial respiratory chain enzymes.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, Research & Experimental
Tayebeh Noori, Ahmad Reza Dehpour, Seyede Darya Alavi, Seyede Zahra Hosseini, Sina Korani, Antoni Sureda, Jamileh Esmaeili, Samira Shirooie
Summary: This study demonstrates that administration of ivermectin and nano-ivermectin is capable of reducing demyelination in mice, with nano-ivermectin showing better efficacy.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)