Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease

PAMAM Dendrimers Cross the Blood–Brain Barrier When Administered through the Carotid Artery in C57BL/6J Mice

(2017) Bhairavi Srinageshwar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

(2017) Yung-Chih Kuo et al.   International Journal of Nanomedicine

Anti-Alzheimer's potential of berberine using surface decorated multi-walled carbon nanotubes: A preclinical evidence

(2017) Shikha Lohan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Iminodiacetic acid-conjugated nanoparticles as a bifunctional modulator against Zn 2+ -mediated amyloid β-protein aggregation and cytotoxicity

(2017) Hongchen Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Synergistic effects of negatively charged hydrophobic nanoparticles and (−)-epigallocatechin-3-gallate on inhibiting amyloid β-protein aggregation

(2017) Hongchen Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Nerve growth factor-loaded heparinized cationic solid lipid nanoparticles for regulating membrane charge of induced pluripotent stem cells during differentiation

(2017) Yung-Chih Kuo et al.   Materials Science & Engineering C-Materials for Biological Applications

The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection

(2017) Parvana Hajieva   MOLECULES

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

(2017) Joana Loureiro et al.   MOLECULES

The effects of gold nanoparticles functionalized with ß -amyloid specific peptides on an in vitro model of blood–brain barrier

(2017) J. Ruff et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line

(2017) Sanjeev Kumar Yadav et al.   NANOTECHNOLOGY

Multifunctional liposomes interact with Abeta in human biological fluids: Therapeutic implications for Alzheimer's disease

(2017) Elisa Conti et al.   NEUROCHEMISTRY INTERNATIONAL

Amino acid-modified chitosan nanoparticles for Cu2+ chelation to suppress CuO nanoparticle cytotoxicity

(2017) Yixian Zhang et al.   Journal of Materials Chemistry B

Why Do So Many Drugs for Alzheimer's Disease Fail in Development? Time for New Methods and New Practices?

(2017) Robert E. Becker et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

(2016) Hyek Jin Kwon et al.   ACS Nano

Gold nanoparticle-capped mesoporous silica-based H 2 O 2 -responsive controlled release system for Alzheimer’s disease treatment

(2016) Licong Yang et al.   Acta Biomaterialia

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

(2016) P. Lundquist et al.   ADVANCED DRUG DELIVERY REVIEWS

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

(2016) Yang Liu et al.   BIOMATERIALS

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

(2016) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Protein corona: Opportunities and challenges

(2016) Saeid Zanganeh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease

(2016) Kundlik Gadhave et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Effect of PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) under magnetic field on amyloid beta fibrillation process

(2016) Somayeh Mirsadeghi et al.   Materials Science & Engineering C-Materials for Biological Applications

Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1–42 Mouse Model of Alzheimer’s Disease

(2016) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization

(2016) Alice Polchi et al.   Nanomaterials

Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier

(2016) Yanhua Zhang et al.   Scientific Reports

Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model

(2015) Gorka Gerenu et al.   ACS Chemical Neuroscience

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

(2015) Tiantian Yin et al.   Acta Biomaterialia

The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo

(2015) Houmam Kafa et al.   BIOMATERIALS

Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization,in vitroandin vivoevaluations

(2015) Shubham Misra et al.   DRUG DELIVERY

The Influence of Extremely Low-Frequency Magnetic Field and Magnetic Nanoparticle on $\text{A}{\boldsymbol \beta }_{\boldsymbol {40}}$ Aggregation In Vitro

(2015) Hongli Jia et al.   IEEE TRANSACTIONS ON MAGNETICS

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

(2015) Yosra S.R. Elnaggar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Disruption of Amyloid Prion Protein Aggregates by Cationic Pyridylphenylene Dendrimers

(2015) Svetlana A. Sorokina et al.   MACROMOLECULAR BIOSCIENCE

Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

(2015) Lara Ordóñez-Gutiérrez et al.   Nanomedicine-Nanotechnology Biology and Medicine

Dendrimer nanocarriers drug action: perspective for neuronal pharmacology

(2015) Leonardo Guzman et al.   Neural Regeneration Research

Cerebral Hypoperfusion-Assisted Intra-arterial Deposition of Liposomes in Normal and Glioma-Bearing Rats

(2015) Shailendra Joshi et al.   NEUROSURGERY

Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)

(2015) Neha Atulkumar Singh et al.   Nutrition Journal

Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer’s disease

(2015) Sara Teller et al.   Scientific Reports

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

(2014) Qingxiang Song et al.   ACS Nano

Amyloid Fibrils Enhance Transport of Metal Nanoparticles in Living Cells and Induced Cytotoxicity

(2014) Sreenath Bolisetty et al.   BIOMACROMOLECULES

Effects of Hydroxylated Carbon Nanotubes on the Aggregation of A β 16–22 Peptides: A Combined Simulation and Experimental Study

(2014) Luogang Xie et al.   BIOPHYSICAL JOURNAL

Gold-Nanoparticle-Based Multifunctional Amyloid-β Inhibitor against Alzheimer’s Disease

(2014) Nan Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nanoparticle Enabled Drug Delivery Across the Blood Brain Barrier: in vivo and in vitro Models, Opportunities and Challenges

(2014) Meeta Gidwani et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats

(2014) Jaap Rip et al.   JOURNAL OF DRUG TARGETING

Transient cerebral hypoperfusion assisted intraarterial cationic liposome delivery to brain tissue

(2014) Shailendra Joshi et al.   JOURNAL OF NEURO-ONCOLOGY

Multifunctional Liposomes Reduce Brain  -Amyloid Burden and Ameliorate Memory Impairment in Alzheimer's Disease Mouse Models

(2014) C. Balducci et al.   JOURNAL OF NEUROSCIENCE

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Direct cellular delivery of human proteasomes to delay tau aggregation

(2014) Dong Hoon Han et al.   Nature Communications

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

Preparation and Characterization of Methylene blue Nanoparticles for Alzheimer’s Disease and Other Tauopathies

(2014) Umesh Jinwal et al.   Current Drug Delivery

Towards designer nanoemulsions for precision delivery of therapeutics

(2014) Frank Sainsbury et al.   Current Opinion in Chemical Engineering

Targeted Drug Delivery Across the Blood Brain Barrier in Alzheimer’s Disease

(2013) Sandra Rocha   CURRENT PHARMACEUTICAL DESIGN

Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives

(2013) Junaid Khan et al.   JOURNAL OF CONTROLLED RELEASE

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier

(2013) Gitanjali Sharma et al.   PHARMACEUTICAL RESEARCH

Functionalized Carbon Nanotubes in the Brain: Cellular Internalization and Neuroinflammatory Responses

(2013) Giuseppe Bardi et al.   PLoS One

Potential synergy between tau aggregation inhibitors and tau chaperone modulators

(2013) Laura J Blair et al.   Alzheimers Research & Therapy

Importance of national plans for Alzheimer’s disease and dementia

(2013) Marc Wortmann   Alzheimers Research & Therapy

Age-dependent effects of microglial inhibition in vivo on Alzheimer’s disease neuropathology using bioactive-conjugated iron oxide nanoparticles

(2013) Micaela Glat et al.   JOURNAL OF NANOBIOTECHNOLOGY

Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors

(2013) Steven Ferris et al.   Clinical Interventions in Aging

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Influence of the Physiochemical Properties of Superparamagnetic Iron Oxide Nanoparticles on Amyloid β Protein Fibrillation in Solution

(2012) Morteza Mahmoudi et al.   ACS Chemical Neuroscience

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Nanobiotechnology-based strategies for crossing the blood–brain barrier

(2012) Kewal K Jain   Nanomedicine

Nanotechnology for neurodegenerative disorders

(2012) Francesca Re et al.   Nanomedicine-Nanotechnology Biology and Medicine

Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease

(2012) Michel Grothe et al.   NEUROBIOLOGY OF AGING

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid-β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity

(2012) Yi-Hung Liao et al.   Small

Specific Binding of Alzheimer's Aβ Peptide Fibrils to Single-Walled Carbon Nanotubes

(2012) Steingrimur Stefansson et al.   Nanomaterials and Nanotechnology

Nanotechnological advances for the delivery of CNS therapeutics

(2011) Ho Lun Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

New perspective for the treatment of Alzheimer diseases: Liposomal rivastigmine formulations

(2011) N. Başaran Mutlu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Targeting Vascular Amyloid in Arterioles of Alzheimer Disease Transgenic Mice With Amyloid β Protein Antibody-Coated Nanoparticles

(2011) Joseph F. Poduslo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nanoparticles: Emerging carriers for drug delivery

(2011) Sagar R. Mudshinge et al.   SAUDI PHARMACEUTICAL JOURNAL

Improving the transport of chemotherapeutic drugs across the blood–brain barrier

(2011) Andrea Orthmann et al.   Expert Review of Clinical Pharmacology

Encapsulation of Natural Polyphenolic Compounds; a Review

(2011) Aude Munin et al.   Pharmaceutics

Lipid-based nanoparticles with high binding affinity for amyloid-β1–42 peptide

(2010) Marco Gobbi et al.   BIOMATERIALS

Beta Amyloid Aggregation Inhibitors: Small Molecules as Candidate Drugs for Therapy of Alzheimers Disease

(2010) F. Re et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

(2010) Zhong Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Oxidative Stress and Anxiety: Relationship and Cellular Pathways

(2010) Jaouad Bouayed et al.   Oxidative Medicine and Cellular Longevity

NIC5-15 as a treatment for Alzheimer's: Safety, pharmacokinetics and clinical variables

(2009) Hillel Grossman et al.   Alzheimers & Dementia

Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

(2009) Thommey P. Thomas et al.   BIOMACROMOLECULES

Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain

(2009) Zhao H. Wang et al.   BIOMATERIALS

Biodegradable polymeric nanoparticles based drug delivery systems

(2009) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanoparticle-based targeted drug delivery

(2009) Rajesh Singh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Accumulation of tau induced in neurites by microglial proinflammatory mediators

(2009) Philipp Gorlovoy et al.   FASEB JOURNAL

Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

(2009) Kamila B. Kurakhmaeva et al.   JOURNAL OF DRUG TARGETING

Delirium in elderly adults: diagnosis, prevention and treatment

(2009) Tamara G. Fong et al.   Nature Reviews Neurology

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

A study of rivastigmine liposomes for delivery into the brain through intranasal route

(2008) Karthik Arumugam et al.   ACTA PHARMACEUTICA

TiO2 nanoparticles promote β-amyloid fibrillation in vitro

(2008) Wei-hui Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

(2008) George Perry et al.   CNS & Neurological Disorders-Drug Targets

Treatment Options in Alzheimer’s Disease: Maximizing Benefit, Managing Expectations

(2008) Martin R. Farlow et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

(2008) Barbara Pavan et al.   MOLECULES

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES