Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Therapies in non-alcoholic steatohepatitis (NASH)

(2017) Abdul M. Oseini et al.   LIVER INTERNATIONAL

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations

(2016) Shigeyuki Miyamura et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

(2016) Namir Shaabani et al.   Cell Death & Disease

Suppression of antigen presentation by IL-10

(2015) Sharad K Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

(2015) Kele Cui et al.   JOURNAL OF HEPATOLOGY

Allo-transplantation of mesenchymal stem cells attenuates hepatic injury through IL1Ra dependent macrophage switch in a mouse model of liver disease

(2015) Kuei-Chuan Lee et al.   JOURNAL OF HEPATOLOGY

Alcoholic liver disease: mechanisms of injury and targeted treatment

(2015) Alexandre Louvet et al.   Nature Reviews Gastroenterology & Hepatology

Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis

(2013) Yoon Seok Roh et al.   HEPATOLOGY

Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice

(2013) Elea Conrad et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

The innate immune response during liver inflammation and metabolic disease

(2013) Veerle Bieghs et al.   TRENDS IN IMMUNOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells

(2010) Jan Petrasek et al.   HEPATOLOGY

Albumin fusion of thioredoxin — The production and evaluation of its biological activity for potential therapeutic applications

(2010) Shotaro Ikuta et al.   JOURNAL OF CONTROLLED RELEASE

Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics

(2010) Kenshiro Hirata et al.   JOURNAL OF CONTROLLED RELEASE

Immune mechanisms in alcoholic liver disease

(2009) Emanuele Albano et al.   Genes and Nutrition

Immune-mediated liver injury

(2009) Ansgar W. Lohse et al.   JOURNAL OF HEPATOLOGY

Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice

(2008) Hiroyuki Nakashima et al.   HEPATOLOGY