Article
Medicine, Research & Experimental
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Summary: The study reveals that KDM1A regulates the stemness of thyroid cancer and promotes cancer progression through the Wnt/beta-catenin pathway. Inhibiting KDM1A can significantly inhibit thyroid cancer progression and enhance sensitivity to chemotherapy.
Article
Cell Biology
Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Shuying Shen, Jianjun Ma
Summary: Recent studies have identified circSIPA1L1 as an upregulated circular RNA in osteosarcoma, which acts as a molecular sponge for miR-411-5p to increase RAB9A expression, promoting tumorigenesis. Silencing circSIPA1L1 attenuates the malignant properties of OS cells, and inhibition of miR-411-5p or overexpression of RAB9A reverses the anti-tumor effects caused by circSIPA1L1 knockdown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sayra Dilmac, Nilay Kuscu, Ayse Caner, Sendegul Yildirim, Burcak Yoldas, Ammad Ahmad Farooqi, Gamze Tanriover
Summary: This study investigated the roles of SIRT and FoxO proteins in breast cancer metastasis and found that SIRT1 co-operates with FoxO proteins and plays a critical role in metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ying Liu, Changmou Yang, Shisheng Chen, Weihao Liu, Jingyi Liang, Shuhua He, Jialiang Hui
Summary: This study reveals that miR-375 promotes osteoblastic metastasis and tumor progression in prostate cancer by upregulating the Wnt signaling pathway.
CANCER GENE THERAPY
(2022)
Review
Medicine, Research & Experimental
Ning Zhang, Xianyu Hu, Yinan Du, Juan Du
Summary: Colorectal cancer is the third most common and fourth most deadly cancer worldwide, with microRNAs playing essential roles in CRC and serving as potential targets for therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Yuechao Sun, Weipeng Gong, Song Zhang
Summary: The study revealed the dual role of METTL3 in colorectal cancer as both an m6A writer and a transcription regulator, working together in the same signaling pathway to drive the malignancy of colorectal cancer.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Kuang He, Wen-Juan Gan
Summary: The Wnt/beta-catenin signaling pathway is closely associated with the carcinogenesis and progression of colorectal cancer (CRC), playing a crucial role in cancer-related processes. Hyperactivation of the pathway is observed in almost all CRC cases and contributes to cancer stem cell propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss the involvement of the Wnt/beta-catenin signaling pathway in CRC and potential therapeutic approaches.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
RongXin Xiao, Hong Wang, Biao Yang
Summary: The study showed that overexpression of miR-98-5p can inhibit the growth and spread of cervical cancer cells, and promote cell apoptosis, making it a potential target for future research in treating cervical cancer.
Review
Pathology
Mohsen Karami Fath, Ramtin Akhavan Masouleh, Negin Afifi, Shirin Loghmani, Parham Tamimi, Alireza Fazeli, Seyed Ali Mousavian, Mohammad Mehdi Falsafi, Ghasem Barati
Summary: The PI3K/Akt/mTOR signaling pathway controls various cellular behaviors, and dysregulated circRNAs have been found to upregulate this pathway, promoting breast tumor initiation, growth, and progression. The dysregulation of PI3K/Akt-regulating circRNAs is correlated with clinical features of breast cancer. Targeting these circRNAs may be a promising option for cancer therapy. Understanding the molecular pathogenesis of the circRNA-PI3K/AKT axis may lead to the development of new therapeutic and diagnostic approaches for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Anli Yang, Fu Peng, Lewei Zhu, Xing Li, Shunling Ou, Zhongying Huang, Song Wu, Cheng Peng, Peng Liu, Yanan Kong
Summary: Melatonin treatment downregulated FUNDC1 and lnc049808 in TNBC cell lines, which inhibited cell proliferation, invasion, and metastasis. lnc049808 and FUNDC1 acted as competing endogenous RNAs binding to miR-101, indicating a potential therapeutic pathway for TNBC progression inhibition by melatonin.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Liangliang Ren, Minxiao Jiang, Dingwei Xue, Huan Wang, Zeyi Lu, Lifeng Ding, Haiyun Xie, Ruyue Wang, Wenqin Luo, Li Xu, Mingchao Wang, Shicheng Yu, Sheng Cheng, Liqun Xia, Haifeng Yu, Peng Huang, Naijin Xu, Gonghui Li
Summary: The study reveals that nitroxoline suppresses metastasis in bladder cancer via the EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Tao Han, Tingsong Chen, Lujun Chen, Kerui Li, Daimin Xiang, Lei Dou, Hengyu Li, Yubei Gu
Summary: This study found that HLF regulates stemness, proliferation, and metastasis of ovarian cancer cells by activating YAP1 and modulating the Hippo signaling pathway. MiR-520e directly targets HLF and is negatively correlated with HLF and YAP1 expression in ovarian cancer tissues. The HLF/YAP1 axis determines the response of ovarian cancer cells to carboplatin treatment. HLF may predict the benefits of carboplatin in ovarian cancer patients.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano, Carlo Cenciarelli
Summary: The p53 protein, known as the guardian of the genome, plays a critical role in preserving genomic integrity, and mutations in the TP53 gene can lead to uncontrolled cell proliferation and cancer formation. With p53 deficiency being common in human cancer, restoring p53 function may be an effective approach for cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Weipu Mao, Keyi Wang, Si Sun, Jianping Wu, Ming Chen, Jiang Geng, Ming Luo
Summary: The study revealed that ID2 serves as a tumor suppressor in bladder cancer, with high ID2 expression associated with lower tumor staging and better survival rates. Mechanistically, ID2 inhibits the progression and metastasis of BCa through the PI3K/AKT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Roodabeh Bahramsoltani, Mohammad Hosein Farzaei, Amin Iranpanah, Mannan Hajimahmoudi, Zeinab Pourjabar, Maria Daglia, Cristina Santarcangelo, Khodabakhsh Rashidi, Seyed Mohammad Nabavi, Roja Rahimi
Summary: This study assessed the phytochemical and toxicological properties of T. stricta, a plant native to Iran. The results showed that the extract of T. stricta is rich in polyphenols and showed no signs of toxicity. Further pharmacological evaluations are recommended to explore the therapeutic properties of this plant.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Polymer Science
Soughand Sayadnia, Elham Arkan, Rana Jahanban-Esfahlan, Sahar Sayadnia, Mehdi Jaymand
Summary: The study investigated the drug delivery performance of pH-responsive magnetic hydrogels composed of tragacanth gum, poly(acrylic acid), and Fe(3)O(4) nanoparticles. The hydrogels showed excellent drug loading and encapsulation efficiencies due to strong hydrogen bonding and electrostatic interaction. They exhibited highest drug release values in cancerous conditions, making them potential drug delivery systems for chemo/hyperthermia therapy of solid tumors.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Nutrition & Dietetics
Raci Karayigit, Alireza Naderi, Firat Akca, Carlos Janssen Gomes da Cruz, Amir Sarshin, Burak Caglar Yasli, Gulfem Ersoz, Mojtaba Kaviani
Summary: The study found that consuming caffeinated coffee can improve lower body muscular endurance and cognitive performance in female athletes without adverse effects on cardiac autonomic function.
Article
Pharmacology & Pharmacy
Ankush Sharma, Devesh Tewari, Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Solomon Habtemariam
Summary: The lungs, with the largest surface area in the body, are more susceptible to airborne pathogens and pollutants that mediate pathologies through ROS. Excessive ROS production leads to pulmonary diseases, where mitochondrial dysfunction plays a prominent role, and therapeutic strategies include reducing oxidative stress.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Mojtaba Mojtahedzadeh, Mahdi Mashhadi Akbar Boojar, Solomon Habtemariam, Seyed Mohammad Nabavi, Atabak Najafi, Amirhosein Ghahremanian, Mohammad Baktash, Safieh Aghaabdollahian, Antoni Sureda, Mahdi Bagheri
Summary: This study systematically reviewed the efficacy of oral products in controlling and reducing VAP, selecting 18 relevant articles and finding that chlorhexidine and some oral herbal medications are beneficial in preventing VAP.
PHYTOTHERAPY RESEARCH
(2021)
Review
Food Science & Technology
Sara Beigrezaei, Zeinab Yazdanpanah, Sepideh Soltani, Seiede Hamide Rajaie, Sahar Mohseni-Takalloo, Tayebeh Zohrabi, Mojtaba Kaviani, Scott C. Forbes, Julien S. Baker, Amin Salehi-Abargouei
Summary: This systematic review and meta-analysis suggests that adding exercise to a weight-loss diet does not significantly reduce inflammatory biomarkers compared to a weight-loss diet alone.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Endocrinology & Metabolism
Sahar Mohseni-Takalloo, Sara Beigrezaei, Zeinab Yazdanpanah, Seyede Hamide Rajaie, Sepideh Soltani, Tayebeh Zohrabi, Mojtaba Kaviani, Scott C. Forbes, Julien S. Baker, Amin Salehi-Abargouei
Summary: This study conducted a systematic review and meta-analysis to evaluate the effect of adding exercise to a hypo-caloric diet during a weight-loss program on sex hormones in adults with overweight/obesity. The results showed that exercise had no significant effect on testosterone, estradiol, and sex hormone-binding globulin levels when added to low-calorie diets.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Oncology
Masoumeh Sharifi-Azad, Marziyeh Fathi, William C. Cho, Abolfazl Barzegari, Hamed Dadashi, Mehdi Dadashpour, Rana Jahanban-Esfahlan
Summary: Colorectal cancer is one of the deadliest cancers, and multiple drug resistance poses a major obstacle in its treatment. This paper discusses various targeting strategies, such as exosomes, liposomes, hydrogels, cell-based carriers, and theranostics, to overcome therapeutic resistance. The potential of emerging approaches involving single-cell methods and computer-aided drug delivery is also explored.
CANCER CELL INTERNATIONAL
(2022)
Article
Polymer Science
Ali Khani, Morteza Eskandani, Hossein Derakhshankhah, Khadijeh Soleimani, Sattar Akbari Nakhjavani, Bakhshali Massoumi, Rana Jahanban-Esfahlan, Kave Moloudi, Mehdi Jaymand
Summary: An efficient and facile bioinspired drug delivery system was successfully developed based on tragacanth gum, which was modified to form a pH- and reduction-sensitive magnetic hydrogel. The system exhibited excellent drug encapsulation efficiency and potential for cancer treatment.
JOURNAL OF POLYMER RESEARCH
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rana Jahanban-Esfahlan, Seyed Hassan Seradj, Zohreh Amoozgar, William C. Cho
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Hossein Derakhshankhah, Babak Haghshenas, Morteza Eskandani, Rana Jahanban-Esfahlan, Saeid Abbasi-Maleki, Mehdi Jaymand
Summary: A folate-conjugated pH- and thermal-sensitive magnetic hydrogel was developed as a smart drug delivery system for chemo/hyperthermia therapy of cancer cells. The hydrogel showed suitable drug loading and encapsulation efficiencies, and exhibited pH- and thermal-responsive drug release behavior under tumor conditions. The developed drug delivery system demonstrated synergistic cancer therapy by combining chemotherapy and hyperthermia approaches.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Environmental Sciences
Mohammad Samadi, Ali Askarian, Hossein Shirvani, Alireza Shamsoddini, Abolfazl Shakibaee, Scott C. Forbes, Mojtaba Kaviani
Summary: The purpose of this study was to investigate the effects of creatine loading after four weeks of beta-alanine supplementation on physical performance, blood lactate, cognitive performance, and resting hormonal concentrations. The results showed that creatine loading enhanced muscular strength and cognitive performance compared to beta-alanine supplementation alone.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Pharmacology & Pharmacy
Hamed Dadashi, Morteza Eskandani, Leila Roshangar, Masoumeh Sharifi-Azad, Mohammad Shahpouri, William C. Cho, Rana Jahanban-Esfahlan
Summary: Surgery is an effective and common treatment for cancer patients, but it faces the challenge of tumor recurrence. Hydrogels, responsive to internal or external stimuli, have been utilized in various therapeutic strategies to control drug release and prevent recurrence. Combined treatments, such as photothermal therapy and chemotherapy, show promise in achieving synergistic effects. Remotely controlled hydrogels offer minimally invasive and on-demand therapy options. This review highlights the importance of externally/remotely-controlled hydrogels in cancer therapy, combination therapies, and on-demand drug release, as well as their potential in preventing post-surgery recurrence and tissue regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Hossein Mahmudi, Mohammad Amin Adili-Aghdam, Mohammad Shahpouri, Mehdi Jaymand, Zohreh Amoozgar, Rana Jahanban-Esfahlan
Summary: Chitosan and its derivatives have diverse medical applications, particularly in cancer treatment. They have the ability to take on various shapes and cross biological barriers. Combined with other biomaterials, they can be used for controlled drug release, targeted delivery, and combination therapy. This article provides an overview of different forms and properties of chitosan, discusses its use as an efficient drug delivery system to overcome therapeutic barriers in solid tumors, and explores the clinical translation and future prospects of chitosan nanoparticles in treating recurrent cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Seyedeh Zahra Alamolhoda, Nosratollah Zarghami, Houman Kahroba, Ahmad Mehdipour, Mohammad Pourhassan-Moghaddam, Rana Jahanban-Esfahlan, Morteza Milani
Summary: Antibiotic resistance is a serious global health issue. Rapid diagnosis and treatment are crucial. Traditional and molecular techniques are expensive and complex, while there is a high demand for inexpensive and accessible point-of-care diagnostics. Isothermal amplification of nucleic acids is a simple and efficient method for biosensing of antimicrobial resistance.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
