Article
Biochemistry & Molecular Biology
Hualin Chen, Lin Ma, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: POLR3G is highly expressed in bladder cancer and is associated with poor prognosis. Its deficiency inhibits migration and invasion of bladder cancer cells and reduces the expression of EMT-related markers. Mechanistically, POLR3G can promote EMT in bladder cancer by activating the PI3K/AKT signaling pathway.
Article
Medicine, Research & Experimental
Tao Xu, Ting Rao, Wei-Ming Yu, Jin-Zhuo Ning, Xi Yu, Shao-Ming Zhu, Kang Yang, Tao Bai, Fan Cheng
Summary: The study revealed that NFKBIZ has low expression in bladder cancer and inhibits the proliferation of bladder cancer cells through the PTEN/PI3K/Akt signaling pathway. This suggests that NFKBIZ may serve as a novel prognostic biomarker and potential therapeutic target for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Review
Biochemistry & Molecular Biology
Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chenhao Tong, Yali Wang, Jiandong Li, Wenda Cen, Weiguang Zhang, Zhiyang Zhu, Jianhua Yu, Baochun Lu
Summary: Pterostilbene (PTS) shows potential as a drug for treating gallbladder cancer by inhibiting cell proliferation, migration, and invasion, inducing apoptosis, and reversing epithelial-mesenchymal transition (EMT) through PI3K/Akt signaling inhibition. Tumor xenograft models also demonstrate PTS's ability to inhibit tumor growth with low toxicity, consistent with in vitro data.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Zhao-Ming Xiao, Dao-Jun Lv, Yu-Zhong Yu, Chong Wang, Tao Xie, Tao Wang, Xian-Lu Song, Shan-Chao Zhao
Summary: This study revealed that SMARCC1 was downregulated in prostate adenocarcinoma, correlated with higher Gleason score and poor prognosis. Depletion of SMARCC1 accelerated PCa cell proliferation and migration by activating the PI3K/AKT pathway. Therefore, SMARCC1 may serve as a novel therapeutic target for treating PCa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yue Wang, Ying Li, Liang Wang, Buze Chen, Miaolin Zhu, Chunyi Ma, Chunyan Mu, Aibin Tao, Shibao Li, Lan Luo, Ping Ma, Shuai Ji, Ting Lan
Summary: In this study, it was found that cinnamaldehyde (CA) inhibits the proliferation and invasion ability of ovarian cancer cells and plays a role in promoting apoptosis and inhibiting the PI3K/AKT signaling pathway. Additionally, CA also inhibits the EGF-induced EMT process. In vivo experiments showed significant repression of ovarian cancer progression and metastasis by CA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Oncology
Mujie Ye, Jiajun He, Jingjing Zhang, Baihui Liu, Xiangqi Liu, Lulu Xie, Meng Wei, Rui Dong, Kai Li, Duan Ma, Kuiran Dong
Summary: The study found that USP7 is highly expressed in hepatoblastoma and both knockdown and overexpression of USP7 significantly affect cell proliferation, migration, and invasion. USP7 may influence HB tumorigenesis through the PI3K/AKT signaling pathway, with potential implications for future treatment.
Article
Oncology
Ofri Doppelt-Flikshtain, Amin Younis, Tal Tamari, Ofir Ginesin, Talia Shentzer-Kutiel, David Nikomarov, Gil Bar-Sela, Benjamin R. Coyac, Yehuda G. Assaraf, Hadar Zigdon-Giladi
Summary: Despite progress in the treatment of various cancers, the prognosis for patients with metastatic osteosarcoma remains poor. This study demonstrated that endothelial progenitor cells (EPCs) play a role in promoting osteosarcoma progression and aggressiveness through non-physical interactions, and revealed a potential underlying molecular mechanism. These findings suggest the possibility of developing EPCs-targeted therapies to inhibit osteosarcoma metastasis and improve treatment efficacy.
Article
Biochemistry & Molecular Biology
Jia-cheng Xu, Tian-yin Chen, Le-tai Liao, Tao Chen, Quan-lin Li, Jia-xin Xu, Jian-wei Hu, Ping-hong Zhou, Yi-qun Zhang
Summary: Our study revealed that high expression of NETO2 in ESCC patients was associated with tumor staging and lymph node metastasis, promoting ESCC progression through enhancing cell proliferation, suppressing apoptosis, and stimulating tumor growth. Additionally, NETO2 was found to play a crucial role in regulating migration, invasion, and epithelial-mesenchymal transition in ESCC cells. Mechanistically, NETO2 activated ERK, PI3k/AKT, and Nrf2 signaling pathways, with Nrf2 identified as a critical downstream mediator responsible for tumorigenesis. This suggests that NETO2 may serve as a potential therapeutic target or prognostic biomarker for ESCC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun, Xuesong Chen
Summary: The study reveals that TPI1 is highly expressed in breast cancer and is associated with clinicopathological characteristics and prognosis. TPI1 promotes breast cancer progression by regulating the PI3K/AKT/mTOR pathway, with CDCA5 and P62 being important mediators.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Weipu Mao, Keyi Wang, Yuan Wu, Jinliang Ni, Houliang Zhang, Yidi Wang, Zonglin Wu, Ruiji Liu, Jiang Geng, Shuqiu Chen, Ming Chen
Summary: This study assessed the prognostic value of the advanced lung cancer inflammatory index (ALI) and modified ALI (mALI) in patients with renal cell carcinoma (RCC). Low ALI and low mALI were associated with poorer prognosis in RCC patients undergoing laparoscopic nephrectomy. Preoperative mALI can be used as a potential independent prognostic indicator for RCC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Surgery
Si Sun, Weipu Mao, Shuchun Tao, Lilin Wan, Xiangyu Zou, Guangyuan Zhang, Ming Chen
Summary: The aim of this study was to assess the effect of preoperative blood glucose levels on the length of stay in patients with kidney stones undergoing percutaneous nephrolithotomy. The results demonstrated that higher preoperative blood glucose levels were significantly associated with longer length of stay in these patients.
FRONTIERS IN SURGERY
(2022)
Article
Environmental Sciences
Jinliang Ni, Ziye Li, Yi Lu, Houliang Zhang, Guangchun Wang, Jinbo Xie, Jun Xie, Yidi Wang, Yifan Zhang, Keyi Wang, Weipu Mao, Bo Peng
Summary: Exposure to nephrotoxic metals such as cadmium and lead is associated with the occurrence of urinary incontinence in women.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Keyi Wang, Yongzhe Gu, Jinliang Ni, Houliang Zhang, Yidi Wang, Yifan Zhang, Xianchao Sun, Tianyuan Xu, Weipu Mao, Bo Peng
Summary: This study reveals that decreased expression of ZNF268 is associated with tumor progression and poor prognosis in ccRCC. Overexpression of ZNF268 inhibits tumor cell proliferation, migration, and invasion, and promotes apoptosis. Moreover, ZNF268 expression is positively correlated with immune cell infiltration in the tumor. The study also suggests a potential regulatory axis of AC093157.1/miR-27a-3p in modulating ZNF268 function in ccRCC.
Article
Andrology
Houliang Zhang, Xinran Song, Jinliang Ni, Weipu Mao, Changxiu Tian, Jinbo Xie, Yifan Zhang, Yidi Wang, Jian Wan, Keyi Wang, Bo Peng
Summary: In this study, a functional vascularized penile tissue engineering model was constructed using an improved penile scaffold. The scaffold was conjugated with heparin and reseeded with human umbilical vein endothelial cells to generate blood vessels in rats. The results showed that the heparin-conjugated scaffold provided a better environment for cell growth and significantly increased the number of blood vessels.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Letter
Medicine, General & Internal
Yidi Wang, J. Ni, W. Mao, H. Zhang, L. Yin, T. Zhang, K. Wang, S. Chen, M. Chen
BMJ MILITARY HEALTH
(2022)
Article
Oncology
Weipu Mao, Keyi Wang, Wentao Zhang, Shuqiu Chen, Jinbo Xie, Zongtai Zheng, Xue Li, Ning Zhang, Yuanyuan Zhang, Haimin Zhang, Bo Peng, Xudong Yao, Jianping Che, Junhua Zheng, Ming Chen, Wei Li
Summary: The study found that the expression of SLERCC was downregulated in RCC and that exogenous upregulation of SLERCC could suppress the metastasis of RCC cells. Further experimental results showed that the PSPM-NPs nanotherapeutic system could effectively inhibit the growth of RCC metastases in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jinbo Xie, Jinliang Ni, Huajuan Shi, Keyi Wang, Xiaoying Ma, Wei Li, Bo Peng
Summary: This study confirmed the upregulation of lncRNA SNHG3 in nonmuscle-invasive bladder cancer, and suggested that the SNHG3/c-MYC/BMI1 axis may be a novel target for regulating tumor growth and metastasis in this disease.
Article
Oncology
Keyi Wang, Tao Zhang, Jinliang Ni, Jianghong Chen, Houliang Zhang, Guangchun Wang, Yongzhe Gu, Bo Peng, Weipu Mao, Jianping Wu
Summary: This study identified prognostic factors for survival in patients with malignant adrenal tumors and established predictive nomograms. The nomograms showed better predictive performance than traditional staging methods and were effective in clinical application. The study contributes to optimizing individualized clinical treatments for patients with malignant adrenal tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Yifan Zhang, Changxiu Tian, Yidi Wang, Houliang Zhang, Jinliang Ni, Wei Song, Huajuan Shi, Tao Zhang, Changbao Xu, Keyi Wang, Bo Peng
Summary: This study aimed to examine the association between kidney stones and sarcopenia in the adult population of the United States from 2011 to 2018. The findings suggest a significant inverse relationship between sarcopenia and the odds of developing kidney stones.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Atrayee Bhattacharya, Atsushi Fushimi, Keyi Wang, Nami Yamashita, Yoshihiro Morimoto, Satoshi Ishikawa, Tatsuaki Daimon, Tao Liu, Song Liu, Mark D. Long, Donald Kufe
Summary: Chronic inflammation plays a crucial role in promoting cancer progression through epigenetic reprogramming. In this study, we demonstrate that the MUC1-C protein, activated by the NF-kappa B pathway, regulates H3K4 methylation levels and the expression of COMPASS SET1A/SETD1A and WDR5 genes. Furthermore, MUC1-C, along with other proteins, is involved in the expression of key regulators of pluripotency network and stemness.
COMMUNICATIONS BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Zonglin Wu, Jinliang Ni, Houliang Zhang, Yifan Zhang, Chengxun Lv, Yidi Wang, Keyi Wang, Bo Peng
Summary: This study investigates the role and mechanism of MLC1 in prostate cancer. The expression of MLC1 is significantly reduced in prostate cancer samples and is negatively correlated with tumor metastasis and positively correlated with patient survival. In vitro experiments demonstrate that up-regulating MLC1 inhibits tumor progression, while down-regulating MLC1 promotes tumor progression. Additionally, the study confirms the reduction of tumor volume in vivo through up-regulation of MLC1. These findings suggest that MLC1 can serve as a potential therapeutic target and exert its anti-tumor effects through inhibition of the PI3K/AKT signaling pathway.
Article
Oncology
Houliang Zhang, Yifan Zhang, Liu Gao, Wei Song, Haipeng Zhang, Guangcan Yang, Yidi Wang, Jinliang Ni, Keyi Wang, Guangchun Wang, Weipu Mao
Summary: This study utilized the TCGA database to identify cuproptosis-related long non-coding RNAs (CRlncRNAs) and construct risk signatures in KIRC patients. Prognosis-associated CRlncRNAs were identified through Lasso regression analysis, and risk signatures were constructed and validated. Kaplan-Meier survival curves showed that high-risk patients had significantly shorter overall survival. The prognostic nomogram based on age, grade, stage, and risk signature had high accuracy in predicting 1-, 3-, and 5-year overall survival rates.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wei Song, Huiqing Hu, Jinliang Ni, Haipeng Zhang, Houliang Zhang, Jiahao Lu, Keyi Wang, Weipu Mao, Bo Peng
Summary: This study examined the relationship between muscle-fat ratio (MFR) and kidney stone disease (KSD) in the adult population of the United States. The results showed that MFR was negatively associated with the prevalence of KSD, and increasing MFR was associated with a decreased risk of developing KSD. The predictive model based on multifactorial logistic regression showed some accuracy and clinical applicability for predicting KSD prognosis.
