TOR signaling in plants: conservation and innovation

Autophagy: The Master of Bulk and Selective Recycling

(2018) Richard S. Marshall et al.   Annual Review of Plant Biology

mTOR signaling in stem and progenitor cells

(2018) Delong Meng et al.   DEVELOPMENT

Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response

(2018) Pengcheng Wang et al.   MOLECULAR CELL

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

(2018) Bernhard Wurzinger et al.   PLANT PHYSIOLOGY

The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation

(2017) Toru Tamahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks

(2017) Kun-hsiang Liu et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MRFFamily Genes Are Involved in Translation Control, Especially under Energy-Deficient Conditions, and Their Expression and Functions Are Modulated by the TOR Signaling Pathway

(2017) Du-Hwa Lee et al.   PLANT CELL

Regulatory-associated protein of TOR (RAPTOR) alters the hormonal and metabolic composition of Arabidopsis seeds, controlling seed morphology, viability and germination potential

(2017) Mohamed A. Salem et al.   PLANT JOURNAL

Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants

(2017) Mikhail Schepetilnikov et al.   PLANT PHYSIOLOGY

Differential TOR activation and cell proliferation inArabidopsisroot and shoot apexes

(2017) Xiaojuan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfur availability regulates plant growth via glucose-TOR signaling

(2017) Yihan Dong et al.   Nature Communications

The TOR Pathway Is Involved in Adventitious Root Formation in Arabidopsis and Potato

(2017) Kexuan Deng et al.   Frontiers in Plant Science

TOR-Dependent and -Independent Pathways Regulate Autophagy in Arabidopsis thaliana

(2017) Yunting Pu et al.   Frontiers in Plant Science

TOR Signaling and Nutrient Sensing

(2016) Thomas Dobrenel et al.   Annual Review of Plant Biology

Ribosomal protein S6 kinase1 coordinates with TOR-Raptor2 to regulate thylakoid membrane biosynthesis in rice

(2016) Linxiao Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

TOR Signaling Promotes Accumulation of BZR1 to Balance Growth with Carbon Availability in Arabidopsis

(2016) Zhenzhen Zhang et al.   CURRENT BIOLOGY

Dynamic and diverse sugar signaling

(2016) Lei Li et al.   CURRENT OPINION IN PLANT BIOLOGY

The regulation and plasticity of root hair patterning and morphogenesis

(2016) Jorge E. Salazar-Henao et al.   DEVELOPMENT

WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes

(2016) Gabriela David-Morrison et al.   DEVELOPMENTAL CELL

Upstream ORFs are prevalent translational repressors in vertebrates

(2016) Timothy G Johnstone et al.   EMBO JOURNAL

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The plant energy sensor: evolutionary conservation and divergence of SnRK1 structure, regulation, and function

(2016) Tom Broeckx et al.   JOURNAL OF EXPERIMENTAL BOTANY

Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis

(2016) Fangjie Xiong et al.   NEW PHYTOLOGIST

Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation

(2016) Ella Nukarinen et al.   Scientific Reports

Integration of light and metabolic signals for stem cell activation at the shoot apical meristem

(2016) Anne Pfeiffer et al.   eLife

The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S6

(2016) Thomas Dobrenel et al.   Frontiers in Plant Science

Mutations in the Arabidopsis Lst8 and Raptor genes encoding partners of the TOR complex, or inhibition of TOR activity decrease abscisic acid (ABA) synthesis

(2015) Alena Kravchenko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel links in the plant TOR kinase signaling network

(2015) Yan Xiong et al.   CURRENT OPINION IN PLANT BIOLOGY

The never-ending story: from pluripotency to plant developmental plasticity

(2015) C. Gaillochet et al.   DEVELOPMENT

Organizer-Derived WOX5 Signal Maintains Root Columella Stem Cells through Chromatin-Mediated Repression of CDF4 Expression

(2015) Limin Pi et al.   DEVELOPMENTAL CELL

Spatial Regulation of Root Growth: Placing the Plant TOR Pathway in a Developmental Perspective

(2015) Adam Barrada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

TOR-inhibitor insensitive-1 (TRIN1) regulates cotyledons greening in Arabidopsis

(2015) Linxuan Li et al.   Frontiers in Plant Science

Expression profiling and functional analysis reveals that TOR is a key player in regulating photosynthesis and phytohormone signaling pathways in Arabidopsis

(2015) Pan Dong et al.   Frontiers in Plant Science

Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway

(2014) Chang Sook Ahn et al.   JOURNAL OF EXPERIMENTAL BOTANY

Plant and animal stem cells: similar yet different

(2014) Renze Heidstra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

A mechanistic framework for noncell autonomous stem cell induction inArabidopsis

(2014) Gabor Daum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of epidermal cell fate in Arabidopsis roots: the importance of multiple feedback loops

(2014) John Schiefelbein et al.   Frontiers in Plant Science

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h

(2013) Mikhail Schepetilnikov et al.   EMBO JOURNAL

Ribosomal Protein S6, a Target of Rapamycin, Is Involved in the Regulation of rRNA Genes by Possible Epigenetic Changes inArabidopsis

(2013) Yun-Kyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

(2013) Marie-Hélène Montané et al.   JOURNAL OF EXPERIMENTAL BOTANY

Glucose–TOR signalling reprograms the transcriptome and activates meristems

(2013) Yan Xiong et al.   NATURE

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

(2012) Qingsong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

(2012) Sang Gyun Kim et al.   MOLECULAR CELL

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Mutations in the Arabidopsis Homolog of LST8/G L, a Partner of the Target of Rapamycin Kinase, Impair Plant Growth, Flowering, and Metabolic Adaptation to Long Days

(2012) M. Moreau et al.   PLANT CELL

Target of Rapamycin Signaling Regulates Metabolism, Growth, and Life Span in Arabidopsis

(2012) M. Ren et al.   PLANT CELL

Systemic analysis of inducible target of rapamycin mutants reveal a general metabolic switch controlling growth inArabidopsis thaliana

(2012) Camila Caldana et al.   PLANT JOURNAL

Regulation of mRNA Translation by Signaling Pathways

(2012) P. P. Roux et al.   Cold Spring Harbor Perspectives in Biology

A Gene Regulatory Network for Root Epidermis Cell Differentiation in Arabidopsis

(2012) Angela Bruex et al.   PLoS Genetics

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

ATP-Competitive Inhibitors of mTOR: An Update

(2011) S. Schenone et al.   CURRENT MEDICINAL CHEMISTRY

Viral factor TAV recruits TOR/S6K1 signalling to activate reinitiation after long ORF translation

(2011) Mikhail Schepetilnikov et al.   EMBO JOURNAL

WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex

(2011) R. K. Yadav et al.   GENES & DEVELOPMENT

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants

(2011) Yan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The ATG1/ATG13 Protein Kinase Complex Is Both a Regulator and a Target of Autophagic Recycling in Arabidopsis

(2011) A. Suttangkakul et al.   PLANT CELL

The PP2A Regulatory Subunit Tap46, a Component of the TOR Signaling Pathway, Modulates Growth and Metabolism in Plants

(2011) Chang Sook Ahn et al.   PLANT CELL

Target of Rapamycin Regulates Development and Ribosomal RNA Expression through Kinase Domain in Arabidopsis

(2011) M. Ren et al.   PLANT PHYSIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1–E2F pathway activity

(2010) Rossana Henriques et al.   EMBO JOURNAL

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The TOR Pathway Modulates the Structure of Cell Walls inArabidopsis

(2010) Ruth-Maria Leiber et al.   PLANT CELL

TOR Is a Negative Regulator of Autophagy in Arabidopsis thaliana

(2010) Yimo Liu et al.   PLoS One

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation

(2009) Odon Thiébeauld et al.   EMBO JOURNAL

Sucrose Control of Translation Mediated by an Upstream Open Reading Frame-Encoded Peptide

(2009) F. Rahmani et al.   PLANT PHYSIOLOGY

Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation

(2009) Y. Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY