Article
Endocrinology & Metabolism
Natsuki Miyake, Takashi Nagai, Hidetaka Suga, Satoko Osuka, Takatoshi Kasai, Mayu Sakakibara, Mika Soen, Hajime Ozaki, Tsutomu Miwata, Tomoyoshi Asano, Mayuko Kano, Ayako Muraoka, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Yoshinori Yasuda, Yohei Kawaguchi, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Daisuke Hagiwara, Shintaro Iwama, Akira Iwase, Naoko Inoshita, Hiroshi Arima, Hiroaki Kajiyama
Summary: This study successfully generated PRL-producing cells from human iPSCs and confirmed their endocrine functions. The generated cells showed similar secretory responsiveness as human pituitary cells in vivo. This model could be used in various studies such as drug discovery, prediction of side effects, and elucidation of tumorigenic mechanisms. Furthermore, it may contribute to the development of regenerative medicine for the pituitary gland.
Article
Chemistry, Multidisciplinary
Danielle J. Beetler, Katelyn A. Bruno, Molly M. Watkins, Vivian Xu, Isha Chekuri, Presley Giresi, Damian N. Di Florio, Emily R. Whelan, Brandy H. Edenfield, Sierra A. Walker, Andrea C. Morales-Lara, Anneliese R. Hill, Angita Jain, Matthew E. Auda, Logan P. Macomb, Kathryn A. Shapiro, Kevin C. Keegan, Joy Wolfram, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Houssam Farres, Leslie T. Cooper, DeLisa Fairweather
Summary: This study examines whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men and women reduce acute or chronic myocarditis in male mice. The results demonstrate that EVs from the platelets of healthy individuals can significantly reduce myocarditis and improve cardiac function.
Review
Cell Biology
Taketaro Sadahiro, Masaki Ieda
Summary: Cardiovascular diseases are a leading cause of death worldwide. Direct reprogramming that converts cardiac fibroblasts into cardiomyocytes offers a promising approach for cardiac regeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Andreas Hornblad, Silvia Remeseiro
Summary: Genome architecture, epigenetics, and enhancer function play crucial roles in determining the fate and identity of cells. Reprogramming to induced pluripotent stem cells involves changes in the transcriptional profile and chromatin landscape, which are tightly regulated during normal embryonic development and also during the reprogramming process. Switching off the somatic program and activating the pluripotent program requires dynamic reorganization of the epigenetic landscape, enhancer function, chromatin accessibility, and 3D chromatin topology.
Review
Biochemistry & Molecular Biology
Hiraku Tsujimoto, Kenji Osafune
Summary: This review summarized the remarkable progress in regenerative medicine using iPS cell technologies in recent years, including the establishment of iPS cells, clinical applications, and disease models generated from patient iPS cells. Research has shown the potential of iPS cell technology in treating ophthalmological, neurological, cardiac, hematological, cartilage, and metabolic diseases, providing new insights for the treatment of intractable diseases.
Review
Oncology
Amitava Basu, Vijay K. Tiwari
Summary: Cellular reprogramming involves rewiring the underlying epigenome to convert one cell type into another, holding great promise for therapeutic use in repairing damaged tissues and organs but facing key challenges in application.
CLINICAL EPIGENETICS
(2021)
Review
Ophthalmology
Shin Hatou, Shigeto Shimmura
Summary: Japanese researchers have been at the forefront of corneal regenerative medicine, conducting groundbreaking studies in the field. They have achieved significant advancements in treating corneal epithelial stem cell deficiency and developed innovative products. The use of induced pluripotent stem cells (iPS cells) in corneal regenerative medicine shows great promise and may overcome the limitations of traditional autologous epithelial sheets.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cell Biology
Jennyfer Levoux, Alexandre Prola, Peggy Lafuste, Marianne Gervais, Nathalie Chevallier, Zeynab Koumaiha, Kaouthar Kefi, Laura Braud, Alain Schmitt, Azzedine Yacia, Aurelie Schirmann, Barbara Hersant, Mounia Sid-Ahmed, Sabrina Ben Larbi, Katerina Komrskova, Jakub Rohlena, Frederic Relaix, Jiri Neuzil, Anne-Marie Rodriguez
Summary: Platelets enhance the therapeutic potential of MSCs by transferring mitochondria and promoting pro-angiogenic activity. Activation of the de novo fatty acid synthesis pathway is required for increased secretion of pro-angiogenic factors by platelet-preconditioned MSCs. Testing platelet mitochondria quality before clinical use is crucial for optimizing their effects.
Review
Developmental Biology
Sydney Leaman, Nicolas Marichal, Benedikt Berninger
Summary: Cellular identity can be reprogrammed through gene regulatory networks, and recent research suggests that this reprogramming can mitigate disease phenotypes.
Review
Cell & Tissue Engineering
Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. M. Galler, Mohammad-Hossein Nekoofar, Paul M. H. Dummer
Summary: This systematic review investigated the mechanisms regulating the differentiation of hDP-MSCs and identified several miRNAs involved in this process. Bioinformatic analysis revealed target genes, signaling pathways, and gene ontologies associated with these miRNAs. The findings support the potential application of these specific miRNAs in regulating the directed differentiation of hDP-MSCs in regenerative therapies.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Pharmacology & Pharmacy
Oleksandra Chabanovska, Anne-Marie Galow, Robert David, Heiko Lemcke
Summary: The approval of the first mRNA-based formulation to combat the COVID-19 pandemic marked a breakthrough in mRNA research, highlighting its benefits such as biological origin, safety, simple manufacturing, and potential applications in various medical fields, especially in regenerative medicine. Further research is needed to fully realize the clinical potential of mRNA-based regenerative therapies, but it is only a few steps away from becoming a reality.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Pei Weng, Yuan-Yang Cheng, Hsin-Lun Lee, Tai-Yi Hsu, Yu-Tang Chang, Yao-An Shen
Summary: This study comprehensively investigates the effects of enhanced PRP (ePRP) on the metabolic reprogramming of fibroblasts, revealing that ePRP promotes a shift towards glycolytic energy metabolism in fibroblasts while maintaining redox equilibrium, facilitating wound healing and anti-ageing processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-ichi Ishikawa, Nobutaka Hattori
Summary: This study investigates the potential application of dopaminergic progenitor cells derived from human-induced pluripotent stem cells (iPSCs) in cell therapy for Parkinson's disease (PD). The results show that the differentiation method used in this study successfully generates dopamine neurons from iPSCs, and transplantation of these cells improves motor function in PD model mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yong Li, Radbod Darabi
Summary: Epigenetics plays a crucial role in iPSC technology, affecting reprogramming efficiency and differentiation direction. Aberrations in epigenetic processes during reprogramming can lead iPSCs towards specific lineages or result in acquisition of new cell phenotypes, necessitating consideration of these factors for successful generation and differentiation of iPSCs.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Editorial Material
Cell & Tissue Engineering
G-I. Im
Summary: Currently, there is little evidence to prove the efficacy of regenerative medicine for OA treatment. Clinical applications of regenerative medicine need to ensure both symptomatic relief and structural improvement to delay or avoid the need for joint arthroplasty.
BONE & JOINT RESEARCH
(2021)