Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

(2021) Christian Kupatt et al.   GENE THERAPY

Direct cell reprogramming: approaches, mechanisms and progress

(2021) Haofei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

(2021) James K. Nuñez et al.   CELL

Small-molecule-mediated reprogramming: a silver lining for regenerative medicine

(2020) Yohan Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina

(2020) Nikolas L. Jorstad et al.   Cell Reports

CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular Programming

(2020) Matthew Pandelakis et al.   Cell Systems

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

(2020) Daisuke Doi et al.   Nature Communications

Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage

(2020) Yoshiaki Takei et al.   Scientific Reports

Reprogramming and transdifferentiation - two key processes for regenerative medicine

(2020) Jolanta Hybiak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Direct cell reprogramming for tissue engineering and regenerative medicine

(2019) Alexander Grath et al.   Journal of Biological Engineering

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

(2019) Jason Tchieu et al.   NATURE BIOTECHNOLOGY

Autonomous trisomic rescue of Down syndrome cells

(2019) Momoko Inoue et al.   LABORATORY INVESTIGATION

Targeted removal of epigenetic barriers during transcriptional reprogramming

(2019) Valentin Baumann et al.   Nature Communications

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Woman is first to receive cornea made from ‘reprogrammed’ stem cells

(2019) David Cyranoski   NATURE

Tet3 regulates cellular identity and DNA methylation in neural progenitor cells

(2019) Mafalda Santiago et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell therapy for spinal cord injury using induced pluripotent stem cells

(2019) Narihito Nagoshi et al.   Regenerative Therapy

Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications

(2018) Shogo Matoba et al.   Cell Stem Cell

Computational approaches for predicting key transcription factors in targeted cell reprogramming (Review)

(2018) Guillermo‑Issac Guerrero‑Ramirez et al.   Molecular Medicine Reports

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

(2018) Marisa Karow et al.   NATURE NEUROSCIENCE

Human pluripotent reprogramming with CRISPR activators

(2018) Jere Weltner et al.   Nature Communications

‘Reprogrammed’ stem cells approved to mend human hearts for the first time

(2018) David Cyranoski   NATURE

Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

(2018) Neha Tiwari et al.   Cell Stem Cell

‘Reprogrammed’ stem cells implanted into patient with Parkinson’s disease

(2018) David Cyranoski   NATURE

Induced Pluripotent Stem Cells for Duchenne Muscular Dystrophy Modeling and Therapy

(2018) Lubos Danisovic et al.   Cells

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

(2017) Naoki Ito et al.   Scientific Reports

Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons

(2017) Orly L. Wapinski et al.   Cell Reports

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

(2016) Joshua B. Black et al.   Cell Stem Cell

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies

(2016) Silvia Consalvi et al.   Stem Cells International

Cellular Reprogramming Using Defined Factors and MicroRNAs

(2016) Takanori Eguchi et al.   Stem Cells International

Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails

(2015) Yanbin Fu et al.   CELL RESEARCH

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons

(2015) Lei Zhang et al.   Cell Stem Cell

NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program

(2015) A. Pataskar et al.   EMBO JOURNAL

Present and future challenges of induced pluripotent stem cells

(2015) Mari Ohnuki et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct conversion of human fibroblasts into functional osteoblasts by defined factors

(2015) Kenta Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotency and Epigenetic Reprogramming

(2015) Konrad Hochedlinger et al.   Cold Spring Harbor Perspectives in Biology

Non-Viral Methods For Generating Integration-Free, Induced Pluripotent Stem Cells

(2015) Xiao-Yue Deng et al.   Current Stem Cell Research & Therapy

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

(2015) Radhika Arasala Rao et al.   Scientific Reports

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming

(2014) Xiao Hu et al.   Cell Stem Cell

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

(2014) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

(2014) Guang-Hui Liu et al.   Nature Communications

Activation of GATA4 gene expression at the early stage of cardiac specification

(2014) Ayse E. Yilbas et al.   Frontiers in Chemistry

microRNAs and Cardiac Cell Fate

(2014) Chiara Piubelli et al.   Cells

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Regenerative medicine: Transdifferentiation in vivo

(2013) Lina Fu et al.   CELL RESEARCH

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

The Combined Expression of Pdx1 and MafA with Either Ngn3 or NeuroD Improves the Differentiation Efficiency of Mouse Embryonic Stem Cells into Insulin-Producing Cells

(2013) Huiming Xu et al.   CELL TRANSPLANTATION

Immunogenicity of Pluripotent Stem Cells and Their Derivatives

(2013) Patricia E. de Almeida et al.   CIRCULATION RESEARCH

Induced pluripotent stem cells in medicine and biology

(2013) K. Takahashi et al.   DEVELOPMENT

Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

(2013) Francesco M. Piccolo et al.   MOLECULAR CELL

Generation of oligodendroglial cells by direct lineage conversion

(2013) Nan Yang et al.   NATURE BIOTECHNOLOGY

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Reprogramming with TET

(2013) Hannah Stower   NATURE REVIEWS GENETICS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1

(2013) Xianhui Li et al.   PLoS One

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Concise Review: Harmonies Played by MicroRNAs in Cell Fate Reprogramming

(2013) Sharif Moradi et al.   STEM CELLS

Immunogenicity and Tumorigenicity of Pluripotent Stem Cells and their Derivatives: Genetic and Epigenetic Perspectives

(2013) Yuan Tan et al.   Current Stem Cell Research & Therapy

Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets

(2013) Giulia Fragola et al.   PLoS Genetics

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

(2012) Jenny X. Chen et al.   CIRCULATION RESEARCH

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

Programming human pluripotent stem cells into white and brown adipocytes

(2012) Tim Ahfeldt et al.   NATURE CELL BIOLOGY

Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier

(2012) A. Watanabe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Epigenetic Regulation of Nanog by MiR-302 Cluster-MBD2 Completes Induced Pluripotent Stem Cell Reprogramming

(2012) Man Ryul Lee et al.   STEM CELLS

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

(2011) Frederick Anokye-Danso et al.   Cell Stem Cell

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets

(2011) D. S. Castro et al.   GENES & DEVELOPMENT

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

(2011) Chuanfeng Wu et al.   Frontiers of Medicine

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

(2010) Saiyong Zhu et al.   Cell Stem Cell

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency

(2010) Carlos F. Pereira et al.   Cell Stem Cell

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Conversion of Mouse Epiblast Stem Cells to an Earlier Pluripotency State by Small Molecules

(2010) Hongyan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Open chromatin in pluripotency and reprogramming

(2010) Alexandre Gaspar-Maia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

(2010) Prashant Mali et al.   STEM CELLS

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Human Induced Pluripotent Stem Cells in the Absence of ExogenousSox2

(2009) Wenlin Li et al.   STEM CELLS

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor   expression

(2008) M. Finzsch et al.   DEVELOPMENT

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis

(2008) Efthimia Karantzal et al.   GENOME BIOLOGY