Review
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Ferroptosis is an oxidative-regulated cell death caused by iron-mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can eliminate oxidized lipids to maintain cell membrane integrity. Epigenetic modifications, such as DNA methylation and histone modifications, can regulate ferroptosis by altering gene expression or cell phenotype. Understanding the epigenetic alterations in cancer can help overcome therapeutic resistance and discover new targets for anticancer therapy.
Review
Environmental Sciences
Nasreddine El Omari, Mohamed Bakha, Hamada Imtara, Fatima-Ezzahrae Guaouguaoua, Abdelaali Balahbib, Gokhan Zengin, Abdelhakim Bouyahya
Summary: Epigenetic dysregulation plays a crucial role in cell transformation and cancer, leading to the development of epidrugs to restore cellular memory. Natural bioactive compounds from medicinal plants have been identified as potential epidrugs for cancer therapy, targeting various epigenetic modulators. This review highlights the pharmacodynamic actions of different chemical classes of natural bioactive compounds in epigenetic medications for cancer treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shruti Choudhary, Arpit Doshi, Lerin Luckett-Chastain, Michael Ihnat, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee
Summary: The efficacy of quinazoline-based antiglioma agents is attributed to their effects on microtubule dynamics and inhibition of multiple intracellular targets. Quinazolines not only cause microtubule depolymerization, but also act as low nanomolar inhibitors of EGFR, VEGFR-2, and PDGFR-α. This multitarget activity demonstrates their potential antitumor effects by targeting multiple pathways.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Quratulain Babar, Ayesha Saeed, Tanveer A. Tabish, Sabrina Pricl, Helen Townley, Nanasaheb Thorat
Summary: This comprehensive review discusses the advancements in targeting epigenetics in cancer, with emphasis on various disciplines and novel strategies for treating immunooncological complications of cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Murugan Selvam, Venkateshwarlu Bandi, Saravanaraman Ponne, Cheemala Ashok, Sudhakar Baluchamy
Summary: miR-150 regulates cell proliferation and acts as a tumor suppressor by controlling the levels of EZH1, EZH2, DNMT3A, and DNMT3B.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Cheang Wei Chan, Chin Yoong Yong, How Mun Chang, Pei Ying Ng, Fabian Davamani, Ebenezer Chitra, Vannajan Sanghiran Lee, Kong Wai Tan, Mohd Jamil Maah, Chew Hee Ng
Summary: Copper complexes show promising anticancer properties with increased cytotoxicity towards metastatic breast cancer cells, surpassing the effectiveness of cisplatin. They also demonstrate potential in overcoming drug resistance.
Review
Cell Biology
Heng Wee Tan, Yan-Ming Xu, San-Hai Qin, Guo-Feng Chen, Andy T. Y. Lau
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Richard Kwamla Amewu, Patrick Opare Sakyi, Dorcas Osei-Safo, Ivan Addae-Mensah
Summary: Cancer is a complex disease with drugs targeting potential multiple targets being proposed as cutting-edge treatments. However, drug resistance, systemic toxicity, and ineffectiveness in various cancer treatments remain widespread issues. Therefore, efficient therapeutic agents targeting multiple targets in different cancer cells are suggested.
Article
Pharmacology & Pharmacy
Abdullah Al Mamun, Mohammad Abu Sufian, Md. Sahab Uddin, Dewan Md Sumsuzzman, Philippe Jeandet, Mohammad Safiqul Islam, Hong-Jie Zhang, Ah-Ng Kong, Md. Shahid Sarwar
Summary: Cancer is a deadly disease that requires urgent drug discovery. Cellular senescence has gained attention for its link to cancer therapy. Senescent cells produce harmful effects and senescence inducers and senotherapeutics have been found to inhibit cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shimaa Kamal, Hamed Ahmed Derbala, Seham Soliman Alterary, Abir Ben Bacha, Mona Alonazi, Mohamed Kandeel El-Ashrey, Nahed Nasser Eid El-Sayed
Summary: In this study, new compounds were synthesized and evaluated for their pharmacological activities on colorectal cancer cells, showing promising antioxidant, cytotoxic, and PDK1 and LDHA inhibitory effects. Compound 1b exhibited the strongest inhibitory activity among all tested compounds.
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
Mireia Sueca-Comes, Elena Cristina Rusu, Anna M. Grabowska, David O. Bates
Summary: The number of cancer drugs is increasing, but most research is still focused on a small subset of well-studied targets, with limited investigations into poorly studied kinases.
PHARMACOLOGICAL REVIEWS
(2022)
Article
Chemistry, Medicinal
Sung-Bau Lee, Ting-Yu Chang, Nian-Zhe Lee, Zih-Yao Yu, Chi-Yuan Liu, Hsueh-Yun Lee
Summary: This study introduces novel bisindole molecules as anti-cancer agents that effectively inhibit TLKs activity and demonstrated their anti-cancer effects in vitro. Through structure optimization, six derivatives with potent TLK inhibitory activity were identified, with potential applications in the treatment of various cancers.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Kyeonghee Shim, Hyein Jo, Dooil Jeoung
Summary: In recent decades, RNA-based drugs have shown promise in treating various diseases. The use of messenger RNA (mRNA) allows for the production of a wide range of functional proteins/peptides, making it an attractive approach for vaccines or therapeutics. Delivery systems, such as exosomes and lipid nanoparticles (LNPs), have been explored as effective methods for delivering RNA-based drugs. Cancer/testis antigens (CTAs) are highly expressed in cancer tissues and have the potential to serve as targets for cancer immunotherapy. Clinical studies have demonstrated the benefits of using CTAs encoded by mRNA-LNPs in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yan Liang, Chao Qian, Yinghong Xie, Xiang Huang, Junjie Chen, Yanlin Ren, Ziyi Fu, Yongfei Li, Tianyu Zeng, Fan Yang, Jianwei Zhou, Wei Li, Yongmei Yin, Changqing Wang
Summary: This study found that JWA expression is lower in trastuzumab-resistant breast cancers compared to sensitive ones, and overexpression of JWA can inhibit tumor growth and promote apoptosis. Additionally, low JWA expression in trastuzumab-resistant breast cancers is associated with a poor prognosis. JWA negatively regulates CDK12 and is involved in the G1-to-S transition of the cell cycle, suggesting it may be a potential predictive marker and therapeutic target for trastuzumab resistance in breast cancer.
CELL DEATH DISCOVERY
(2021)