Epigenetic regulation of angiogenesis in lung cancer

Lung cancer is the leading cause of cancer-related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs. Here, we review the current knowledge of the epigenetic regulation of angiogenesis and discuss the potential clinical applications of epigenetic-based anticancer therapy in lung cancer. Overall, epigenetic-based therapy will likely emerge as a prominent approach to treat lung cancer in the future.

Automated summary

Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.