Fenofibrate Ameliorates Oxidative Stress-Induced Retinal Microvascular Dysfunction in Diabetic Rats

Small triumph for fenofibrate therapy in dyslipidaemia

(2017) Robert S. Rosenson   Nature Reviews Cardiology

Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle

(2016) Ashok Mandala et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes

(2016) Jun Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

Peroxisome Proliferator-Activated ReceptorαReduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin

(2016) Hsu-Lung Jen et al.   MEDIATORS OF INFLAMMATION

TXNIP Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions

(2016) Jia Zhou et al.   MEDICAL SCIENCE MONITOR

Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity

(2015) Marta Garcia-Ramírez et al.   ACTA DIABETOLOGICA

Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy

(2015) Sumon Roy et al.   EXPERIMENTAL EYE RESEARCH

Fenofibrate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway

(2015) SHUZHI ZHAO et al.   Molecular Medicine Reports

Peroxisome Proliferator–Activated Receptor α Protects Capillary Pericytes in the Retina

(2014) Lexi Ding et al.   AMERICAN JOURNAL OF PATHOLOGY

Thioredoxin-interacting protein, hematopoietic stem cells, and hematopoiesis

(2014) Haiyoung Jung et al.   CURRENT OPINION IN HEMATOLOGY

Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice

(2014) Ye Rim Cho et al.   PLoS One

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

(2014) Yu Ah Hong et al.   PLoS One

Thioredoxin-Interacting Protein Expression Is Required for VEGF-Mediated Angiogenic Signal in Endothelial Cells

(2013) Mohammed A. Abdelsaid et al.   ANTIOXIDANTS & REDOX SIGNALING

A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

(2013) L. L. Dunn et al.   DIABETES

Fenofibrate – A Potential Systemic Treatment for Diabetic Retinopathy?

(2012) Tien Yin Wong et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Direct Effects of PPARα Agonists on Retinal Inflammation and Angiogenesis May Explain How Fenofibrate Lowers Risk of Severe Proliferative Diabetic Retinopathy

(2012) Steven F. Abcouwer   DIABETES

Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models

(2012) Ying Chen et al.   DIABETES

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Prevalence of diabetic macular oedema and related health and social care resource use in England

(2011) D C Minassian et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions

(2011) Soledad Miranda et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator-Activated Receptor   Coactivator 1 

(2010) Z. Zheng et al.   DIABETES

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

PPARα: an emerging therapeutic target in diabetic microvascular damage

(2010) Anne Hiukka et al.   Nature Reviews Endocrinology

Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

U83836E Inhibits Retinal Neurodegeneration in Early-Stage Streptozotocin-Induced Diabetic Rats

(2010) Hong Wang et al.   OPHTHALMIC RESEARCH

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

Protective Effect of Perindopril on Diabetic Retinopathy Is Associated With Decreased Vascular Endothelial Growth Factor-to-Pigment Epithelium-Derived Factor Ratio: Involvement of a Mitochondria-Reactive Oxygen Species Pathway

(2009) Z. Zheng et al.   DIABETES

PPAR  agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition

(2008) D. Panigrahy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA