Expanding the boundary of biocatalysis: design and optimization of in vitro tandem catalytic reactions for biochemical production

First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols

(2017) Giuseppe Rulli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Leucine zipper-mediated targeting of multi-enzyme cascade reactions to inclusion bodies in Escherichia coli for enhanced production of 1-butanol

(2017) Gui Hwan Han et al.   METABOLIC ENGINEERING

Industrial biomanufacturing: The future of chemical production

(2017) James M. Clomburg et al.   SCIENCE

A synthetic biochemistry platform for cell free production of monoterpenes from glucose

(2017) Tyler P. Korman et al.   Nature Communications

Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction To Efficiently Synthesize Enantioenriched 2-Substituted Succinate Derivatives

(2017) Yajie Wang et al.   ACS Catalysis

Substrate Channeling in an Artificial Metabolon: A Molecular Dynamics Blueprint for an Experimental Peptide Bridge

(2017) Yuanchao Liu et al.   ACS Catalysis

Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

(2017) Nicoló Scalacci et al.   ACS Catalysis

Dynamic kinetic resolution of aromatic sec-alcohols by using a heterogeneous palladium racemization catalyst and lipase

(2017) Yuanfeng Xu et al.   Catalysis Science & Technology

A One-Pot Cascade Reaction Combining an Encapsulated Decarboxylase with a Metathesis Catalyst for the Synthesis of Bio-Based Antioxidants

(2016) Álvaro Gómez Baraibar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimicry Promotes the Efficiency of a 10-Step Sequential Enzymatic Reaction on Nanoparticles, Converting Glucose to Lactate

(2016) Chinatsu Mukai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions

(2016) Todd K. Hyster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering Cellular Metabolism

(2016) Jens Nielsen et al.   CELL

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases

(2016) Xavier Garrabou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme

(2016) Xavier Garrabou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Olefin Metathesis

(2016) Georgios Vougioukalakis   MOLECULES

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

(2016) Hanna M. Key et al.   NATURE

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Immobilized multienzymatic systems for catalysis of cascade reactions

(2016) Qingzhi Ji et al.   PROCESS BIOCHEMISTRY

Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life

(2016) S. B. Jennifer Kan et al.   SCIENCE

A synthetic pathway for the fixation of carbon dioxide in vitro

(2016) Thomas Schwander et al.   SCIENCE

Forward design of a complex enzyme cascade reaction

(2016) Christoph Hold et al.   Nature Communications

Spatial effects of oxovanadium-immobilized mesoporous silica on racemization of alcohols and application in lipase-catalyzed dynamic kinetic resolution

(2016) Koji Sugiyama et al.   Catalysis Science & Technology

Tandem Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

(2016) Yajie Wang et al.   Catalysts

A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates

(2015) Xavier Garrabou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Separation-Integrated Cascade Reaction to Overcome Thermodynamic Limitations in Rare-Sugar Synthesis

(2015) Nina Wagner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media

(2015) Hirofumi Sato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic fusion protein design and applications

(2015) Kai Yu et al.   BIOTECHNOLOGY ADVANCES

Production of biofuels and biochemicals by in vitro synthetic biosystems: Opportunities and challenges

(2015) Yi-Heng Percival Zhang   BIOTECHNOLOGY ADVANCES

Artificial concurrent catalytic processes involving enzymes

(2015) Valentin Köhler et al.   CHEMICAL COMMUNICATIONS

Chemoenzymatic Dynamic Kinetic Resolution: A Powerful Tool for the Preparation of Enantiomerically Pure Alcohols and Amines

(2015) Oscar Verho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cost-effective polyphosphate-based metabolism fuels an all E. coli cell-free expression system

(2015) Filippo Caschera et al.   METABOLIC ENGINEERING

Systems Biocatalysis: Development and engineering of cell-free “artificial metabolisms” for preparative multi-enzymatic synthesis

(2015) Wolf-Dieter Fessner   New Biotechnology

Supramolecular control of transition metal complexes in water by a hydrophobic cavity: a bio-inspired strategy

(2015) Olivia Bistri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-yield hydrogen production from biomass by in vitro metabolic engineering: Mixed sugars coutilization and kinetic modeling

(2015) Joseph A. Rollin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A supramolecular microenvironment strategy for transition metal catalysis

(2015) D. M. Kaphan et al.   SCIENCE

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation

(2015) Poonam Srivastava et al.   Nature Communications

Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides

(2015) Carl A. Denard et al.   ACS Catalysis

A De Novo Designed Metalloenzyme for the Hydration of CO2

(2014) Virginia M. Cangelosi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-free metabolic engineering: Biomanufacturing beyond the cell

(2014) Quentin M. Dudley et al.   Biotechnology Journal

Maximizing the Efficiency of Multienzyme Process by Stoichiometry Optimization

(2014) Pavel Dvorak et al.   CHEMBIOCHEM

Transition metal-mediated bioorthogonal protein chemistry in living cells

(2014) Maiyun Yang et al.   CHEMICAL SOCIETY REVIEWS

Bioretrosynthetic construction of a didanosine biosynthetic pathway

(2014) William R Birmingham et al.   Nature Chemical Biology

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm

(2014) Jinglin Fu et al.   Nature Nanotechnology

Yeast cell-free enzyme system for bio-ethanol production at elevated temperatures

(2014) Waleed Ahmad Khattak et al.   PROCESS BIOCHEMISTRY

A synthetic biochemistry molecular purge valve module that maintains redox balance

(2014) Paul H. Opgenorth et al.   Nature Communications

Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments

(2014) Marcel Heidlindemann et al.   ACS Catalysis

Co-immobilization of an Enzyme and a Metal into the Compartments of Mesoporous Silica for Cooperative Tandem Catalysis: An Artificial Metalloenzyme

(2013) Karin Engström et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

(2013) Carl A. Denard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Materials-based strategies for multi-enzyme immobilization and co-localization: A review

(2013) Feng Jia et al.   BIOTECHNOLOGY AND BIOENGINEERING

Synthesis of heterogeneous enzyme–metal nanoparticle biohybrids in aqueous media and their applications in C–C bond formation and tandem catalysis

(2013) Marco Filice et al.   CHEMICAL COMMUNICATIONS

Enzyme immobilisation in biocatalysis: why, what and how

(2013) Roger A. Sheldon et al.   CHEMICAL SOCIETY REVIEWS

Corrigendum to “Enzyme catalysed tandem reactions” [Curr Opin Chem Biol 17 (2013) 236–249]

(2013) Isabel Oroz-Guinea et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

(2013) Xixian Chen et al.   PLoS One

Fusing catalase to an alkane-producing enzyme maintains enzymatic activity by converting the inhibitory byproduct H2O2 to the cosubstrate O2

(2013) C. Andre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

(2013) Carl A. Denard et al.   ACS Catalysis

Annexation of a High-Activity Enzyme in a Synthetic Three-Enzyme Complex Greatly Decreases the Degree of Substrate Channeling

(2013) Chun You et al.   ACS Synthetic Biology

In silico evaluation of a complex multi-enzymatic system using one-pot and modular approaches: Application to the high-yield production of hydrogen from a synthetic metabolic pathway

(2012) Inés Ardao et al.   CHEMICAL ENGINEERING SCIENCE

Cell-Free Metabolic Engineering: Production of Chemicals by Minimized Reaction Cascades

(2012) Jan-Karl Guterl et al.   ChemSusChem

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

(2012) Sagar D Khare et al.   Nature Chemical Biology

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

Self-Assembly of Synthetic Metabolons through Synthetic Protein Scaffolds: One-Step Purification, Co-immobilization, and Substrate Channeling

(2012) Chun You et al.   ACS Synthetic Biology

Homoallylic Alcohols via a Chemo-Enzymatic One-Pot Oxidation-Allylation Cascade

(2011) Michael Fuchs et al.   ADVANCED SYNTHESIS & CATALYSIS

Combination of Olefin Metathesis and Enzymatic Ester Hydrolysis in Aqueous Media in a One-Pot Synthesis

(2011) Katharina Tenbrink et al.   ADVANCED SYNTHESIS & CATALYSIS

Platinum Nanoparticles Encapsulated by Aminopeptidase: A Multifunctional Bioinorganic Nanohybrid Catalyst

(2011) Boi Hoa San et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

(2011) Hyunjin Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Turnover Supramolecular Catalysis by a Protected Ruthenium(II) Complex in Aqueous Solution

(2011) Casey J. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coarse-Grained Dynamics of Protein Synthesis in a Cell-Free System

(2011) Eyal Karzbrun et al.   PHYSICAL REVIEW LETTERS

Combining bio- and chemo-catalysis: from enzymes to cells, from petroleum to biomass

(2011) Andrew C. Marr et al.   TRENDS IN BIOTECHNOLOGY

Engineering a Biometallic Whole Cell Catalyst for Enantioselective Deracemization Reactions

(2011) Joanne M. Foulkes et al.   ACS Catalysis

Enzyme Mimics Based Upon Supramolecular Coordination Chemistry

(2010) Michael J. Wiester et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Heck Reaction of Allylic Alcohols Catalyzed by Palladium Nanoparticles in Water: Chemoenzymatic Synthesis of (R)-(−)-Rhododendrol

(2010) Alberto Boffi et al.   ChemCatChem

Tandem Enzyme/Gold-Catalysis: From Racemic α-Allenic Acetates to Enantiomerically Enriched 2,5-Dihydrofurans in One Pot

(2009) Martta Asikainen et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Catalysis of the Aza-Cope Rearrangement by a Chiral Supramolecular Assembly

(2009) Casey J. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular Chemoenzymatic One-Pot Syntheses in Aqueous Media: Combination of a Palladium-Catalyzed Cross-Coupling with an Asymmetric Biotransformation

(2008) Edyta Burda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic modeling of a bi-enzymatic system for efficient conversion of lactose to lactobionic acid

(2008) Wouter Van Hecke et al.   BIOTECHNOLOGY AND BIOENGINEERING