Neurovascular dysfunction in dementia – human cellular models and molecular mechanisms

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

A microfluidic circulatory system integrated with capillary-assisted pressure sensors

(2017) Yangfan Chen et al.   LAB ON A CHIP

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

(2017) Chris Cho et al.   NEURON

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

(2016) Carmen Capone et al.   ANNALS OF NEUROLOGY

Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease

(2016) Tetsuya Hashimoto et al.   ANNALS OF NUCLEAR MEDICINE

In vitro blood–brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms

(2016) Jayati Banerjee et al.   DRUG DISCOVERY TODAY

The Translational Significance of the Neurovascular Unit

(2016) Heather L. McConnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research

(2016) Estrela Neto et al.   JOURNAL OF NEUROSCIENCE

Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells

(2016) Matthew J. Stebbins et al.   METHODS

Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation

(2016) Mohammad Hossein Geranmayeh et al.   MOLECULAR NEUROBIOLOGY

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

(2016) Helen Shinru Wei et al.   NEURON

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

(2016) Carmen Capone et al.   eLife

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke PreventionCLINICAL PERSPECTIVE

(2015) Marion Jeanne et al.   CIRCULATION

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRICLINICAL PERSPECTIVE

(2015) Benjamin F.J. Verhaaren et al.   Circulation-Cardiovascular Genetics

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline

(2015) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?

(2015) Anne Joutel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease

(2015) K. Rannikmae et al.   NEUROLOGY

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRICLINICAL PERSPECTIVE

(2015) Benjamin F.J. Verhaaren et al.   Circulation-Cardiovascular Genetics

Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

(2014) Jeremy Hill et al.   Journal of Neuroimmune Pharmacology

Astrocytic Gq-GPCR-Linked IP3R-Dependent Ca2+ Signaling Does Not Mediate Neurovascular Coupling in Mouse Visual Cortex In Vivo

(2014) D. E. Bonder et al.   JOURNAL OF NEUROSCIENCE

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain

(2014) Imola Wilhelm et al.   MOLECULAR PHARMACEUTICS

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes

(2014) Julie Boyer-Di Ponio et al.   PLoS One

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

Initial Contact of Glioblastoma Cells with Existing Normal Brain Endothelial Cells Strengthen the Barrier Function via Fibroblast Growth Factor 2 Secretion: A New In Vitro Blood–Brain Barrier Model

(2013) Keisuke Toyoda et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke

(2013) Lydia S. Murray et al.   HUMAN MOLECULAR GENETICS

A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

(2013) Qiang Xue et al.   International Journal of Biological Sciences

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

The astrocytic contribution to neurovascular coupling – Still more questions than answers?

(2013) Przemysław Kowiański et al.   NEUROSCIENCE RESEARCH

In vitro blood–brain barrier model adapted to repeated-dose toxicological screening

(2013) A. Fabulas-da Costa et al.   TOXICOLOGY IN VITRO

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Establishment of a new conditionally immortalized cell line from human brain microvascular endothelial cells: A promising tool for human blood–brain barrier studies

(2012) Atsuko Kamiichi et al.   BRAIN RESEARCH

An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood–brain barrier model

(2012) Carina A. Cantrill et al.   BRAIN RESEARCH

Notch signalling in smooth muscle cells during development and disease

(2012) C. Fouillade et al.   CARDIOVASCULAR RESEARCH

Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency

(2012) R. Lemmens et al.   HUMAN MOLECULAR GENETICS

COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets

(2012) D. S. Kuo et al.   HUMAN MOLECULAR GENETICS

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

(2012) Sumio Ohtsuki et al.   MOLECULAR PHARMACEUTICS

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Pericytes as a new target for pathological processes in CADASIL

(2012) Dorota Dziewulska et al.   NEUROPATHOLOGY

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

(2012) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurovascular unit in brain function and disease

(2011) C. Lecrux et al.   Acta Physiologica

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Cerebrovascular lesions induce transient  -amyloid deposition

(2011) M. Garcia-Alloza et al.   BRAIN

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

(2011) Kathryn Hatherell et al.   JOURNAL OF NEUROSCIENCE METHODS

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

(2011) J.-E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay

(2010) A. D. van der Meer et al.   Biomicrofluidics

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor

(2010) D. Zhu et al.   BLOOD

Shear stress and the endothelial transport barrier

(2010) John M. Tarbell   CARDIOVASCULAR RESEARCH

Murine in vitro model of the blood–brain barrier for evaluating drug transport

(2010) Gilda Shayan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

(2010) Michael J Bernas et al.   Nature Protocols

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

A microperfused incubator for tissue mimetic 3D cultures

(2009) Jelena Vukasinovic et al.   BIOMEDICAL MICRODEVICES

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

Effects of Habitat Conversion on Temporal Activity Patterns of Phyllostomid Bats in Lowland Amazonian Rain Forest

(2009) Steven J. Presley et al.   JOURNAL OF MAMMALOGY

Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis

(2009) Sarah T Pendlebury et al.   LANCET NEUROLOGY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patients With Alzheimer Disease With Multiple Microbleeds

(2009) Jeroen D.C. Goos et al.   STROKE

Sorting Out Astrocyte Physiology from Pharmacology

(2008) Todd A. Fiacco et al.   Annual Review of Pharmacology and Toxicology

Microbleed Topography, Leukoaraiosis, and Cognition in Probable Alzheimer Disease From the Sunnybrook Dementia Study

(2008) Jacqueline A. Pettersen et al.   ARCHIVES OF NEUROLOGY

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

(2008) Shumei Man et al.   Clinical & Developmental Immunology

Differential effects of hydrocortisone and TNFα on tight junction proteins in anin vitromodel of the human blood-brain barrier

(2008) Carola Förster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Physiological role of inward rectifier K+ channels in vascular smooth muscle cells

(2008) Won Sun Park et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING