From autoinflammation to autoimmunity: old and recent findings

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

(2017) Parimala R. Vajjhala et al.   MOLECULAR IMMUNOLOGY

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases

(2017) Michael Croft et al.   Nature Reviews Rheumatology

Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles

(2017) Arsen Arakelyan et al.   PLoS One

Adult-onset Still’s disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients

(2016) Paolo Sfriso et al.   CLINICAL RHEUMATOLOGY

Emerging drugs for psoriatic arthritis

(2016) Francesco Caso et al.   EXPERT OPINION ON EMERGING DRUGS

Dysregulation of proinflammatory versus anti-inflammatory human T H 17 cell functionalities in the autoinflammatory Schnitzler syndrome

(2016) Rebecca Noster et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoinflammatory diseases: update on classification diagnosis and management

(2016) Shelly Pathak et al.   JOURNAL OF CLINICAL PATHOLOGY

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

The NLRP3 inflammasome in kidney disease and autoimmunity

(2016) Holly L Hutton et al.   NEPHROLOGY

Type I interferonopathies in pediatric rheumatology

(2016) Stefano Volpi et al.   Pediatric Rheumatology

The Role of TLR4 on B Cell Activation and Anti-β2GPI Antibody Production in the Antiphospholipid Syndrome

(2016) Si Cheng et al.   Journal of Immunology Research

αβ T cell receptors as predictors of health and disease

(2015) Meriem Attaf et al.   Cellular & Molecular Immunology

TLR4 is involved in the pathogenic effects observed in a murine model of antiphospholipid syndrome

(2015) Hongxiang Xie et al.   CLINICAL IMMUNOLOGY

Progress in understanding and utilizing TNF-α inhibition for the treatment of psoriatic arthritis

(2015) Francesco Caso et al.   Expert Review of Clinical Immunology

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

Inflammasomes and human autoimmunity: A comprehensive review

(2015) Chin-An Yang et al.   JOURNAL OF AUTOIMMUNITY

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity

(2015) Jolien Suurmond et al.   JOURNAL OF CLINICAL INVESTIGATION

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Type I interferonopathies—an expanding disease spectrum of immunodysregulation

(2015) Min Ae Lee-Kirsch et al.   Seminars in Immunopathology

Advances in the genetically complex autoinflammatory diseases

(2015) Michael J. Ombrello   Seminars in Immunopathology

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway

(2015) Eliana Greco et al.   ARTHRITIS RESEARCH & THERAPY

Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

(2015) Dharma R Thapa et al.   ARTHRITIS RESEARCH & THERAPY

Systemic Autoimmune Diseases 2014

(2015) Guixiu Shi et al.   Journal of Immunology Research

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

(2014) J Suurmond et al.   ANNALS OF THE RHEUMATIC DISEASES

Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials

(2014) Arthur Kavanaugh et al.   ANNALS OF THE RHEUMATIC DISEASES

Caveats and truths in genetic, clinical, autoimmune and autoinflammatory issues in Blau syndrome and early onset sarcoidosis

(2014) Francesco Caso et al.   AUTOIMMUNITY REVIEWS

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases

(2014) Ludvig M Sollid et al.   CURRENT OPINION IN IMMUNOLOGY

The intersection of immune deficiency and autoimmunity

(2014) Solrun M. Maggadottir et al.   CURRENT OPINION IN RHEUMATOLOGY

Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis

(2014) VASANTH KONDA MOHAN et al.   JOURNAL OF GENETICS

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2–Controlled Regulatory T Cell and Increase of IL-21–Mediated Effector T Cell Expansion

(2014) Nina Chevalier et al.   JOURNAL OF IMMUNOLOGY

Biological Treatments in Behçet’s Disease: Beyond Anti-TNF Therapy

(2014) Francesco Caso et al.   MEDIATORS OF INFLAMMATION

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

(2014) Paulina Navon Elkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages

(2014) C.-A. Yang et al.   RHEUMATOLOGY

Anti-Nuclear Antibodies in Daily Clinical Practice: Prevalence in Primary, Secondary, and Tertiary Care

(2014) Thomas Y. Avery et al.   Journal of Immunology Research

Lymphopenia-Induced Proliferation in Aire-Deficient Mice Helps to Explain Their Autoimmunity and Differences from Human Patients

(2014) Kai Kisand et al.   Frontiers in Immunology

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Clinical Guidelines and Definitions of Autoinflammatory Diseases: Contrasts and Comparisons with Autoimmunity—a Comprehensive Review

(2013) M. Zen et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Prospects for therapeutic tolerance in humans

(2013) Kenneth F. Baker et al.   CURRENT OPINION IN RHEUMATOLOGY

Autoinflammatory Syndromes

(2013) John J. Cush   DERMATOLOGIC CLINICS

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

(2013) M. van Lummel et al.   DIABETES

Psoriatic arthritis: advances in pharmacotherapy based on molecular target

(2013) Raffaele Scarpa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Association study of TLR-9 polymorphisms and systemic lupus erythematosus in Northern Chinese Han population

(2013) Jihui Zhang et al.   GENE

Complement and autoimmunity

(2013) Eleonora Ballanti et al.   IMMUNOLOGIC RESEARCH

Refractory pemphigus foliaceus and Behçet’s disease successfully treated with tocilizumab

(2013) Francesco Caso et al.   IMMUNOLOGIC RESEARCH

Successful use of rituximab in a young patient with immunoglobulin G4-related disease and refractory scleritis

(2013) Francesco Caso et al.   JOINT BONE SPINE

A beneficial effect of rituximab on autoimmune thrombotic thrombocytopenic purpura: Just a B-cell depletion?

(2013) Jae Il Shin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Wiskott–Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans

(2013) Maria Carmina Castiello et al.   JOURNAL OF AUTOIMMUNITY

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

(2013) Shlomo Z. Ben-Sasson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

(2013) Z. Hua et al.   JOURNAL OF IMMUNOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders

(2013) Antonio Vitale et al.   MEDIATORS OF INFLAMMATION

Working the endless puzzle of hereditary autoinflammatory disorders

(2013) Francesco Caso et al.   Modern Rheumatology

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

From Immunosuppression to Immunomodulation: Current Principles and Future Strategies

(2013) Jiri Kovarik   PATHOBIOLOGY

Anti-citrullinated protein antibodies: role in pathogenesis of RA and potential as a diagnostic tool

(2013) Sadaf Moeez et al.   RHEUMATOLOGY INTERNATIONAL

Association ofNLRP3andCARD8genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population

(2013) C-A Yang et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: Clinical manifestations and long-term follow-up

(2013) Luca Cantarini et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Treating inflammation by blocking interleukin-1 in humans

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

Negative regulation of NLRP3 inflammasome signaling

(2013) Shuzhen Chen et al.   Protein & Cell

Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans

(2012) David L. Morris et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Efficacy and Safety of Biologic Treatments in Familial Mediterranean Fever

(2012) Akgu Ozgur et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Efficacy of anti-IL-1 treatment in Majeed syndrome

(2012) Troels Herlin et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials

(2012) Susan Manzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Autoinflammation and autoimmunity: Bridging the divide

(2012) A. Doria et al.   AUTOIMMUNITY REVIEWS

Blau syndrome, clinical and genetic aspects

(2012) Paolo Sfriso et al.   AUTOIMMUNITY REVIEWS

NAIPs: Building an innate immune barrier against bacterial pathogens

(2012) Eric M. Kofoed et al.   BIOESSAYS

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

MHC Class II Tetramers

(2012) G. T. Nepom   JOURNAL OF IMMUNOLOGY

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus

(2012) Piotr Piotrowski et al.   RHEUMATOLOGY INTERNATIONAL

Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: Assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab

(2011) Prashantha M. Vaitla et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne)

(2011) Andrew P. Demidowich et al.   ARTHRITIS AND RHEUMATISM

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

(2011) Yin Liu et al.   ARTHRITIS AND RHEUMATISM

Immunologic characteristics of intrarenal T cells: Trafficking of expanded CD8+ T cell β-chain clonotypes in progressive lupus nephritis

(2011) Robert Winchester et al.   ARTHRITIS AND RHEUMATISM

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis

(2011) Olatz Oyanguren-Desez et al.   CELL CALCIUM

High throughput cellular screens to interrogate the human T and B cell repertoires

(2011) Davide Corti et al.   CURRENT OPINION IN IMMUNOLOGY

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

(2011) Takumi Kawasaki et al.   IMMUNOLOGICAL REVIEWS

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus

(2011) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from Southern Brazil

(2011) BP dos Santos et al.   LUPUS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis

(2011) D. Pascual-Salcedo et al.   RHEUMATOLOGY

Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan

(2011) Chung-Ming Huang et al.   RHEUMATOLOGY INTERNATIONAL

Journal Info Home About the Journal Editorial Board Archive Research Topics View Some Authors Review Guidelines Subscribe to Alerts Search Article Type Publication Date ...... Go Author Info Why Submit? Fees Article Types Author Guidelines Submission Checklist Contact Editorial Office Submit Manuscript Review ARTICLE Abstract Full Text PDF 0 Write a Comment Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

(2011) Waleed Al-Herz   Frontiers in Immunology

Clinical Utility of Measuring Infliximab and Human Anti-Chimeric Antibody Concentrations in Patients With Inflammatory Bowel Disease

(2010) Waqqas Afif et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

(2010) Anil K. Agarwal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome

(2010) Antonio Torrelo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Sensors of the innate immune system: their link to rheumatic diseases

(2010) Argyrios N. Theofilopoulos et al.   Nature Reviews Rheumatology

Future perspective for diagnosis in autoimmune diseases

(2009) Luis E. C. Andrade   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Interleukin-6 as a key player in systemic inflammation and joint destruction

(2009) J.E. Fonseca et al.   AUTOIMMUNITY REVIEWS

Wiskott-Aldrich syndrome

(2009) Luigi D Notarangelo et al.   CURRENT OPINION IN HEMATOLOGY

Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

(2009) Yashwant Kumar et al.   Diagnostic Pathology

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Screening Detects a High Proportion of Celiac Disease in Young HLA-genotyped Children

(2009) Sara Björck et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Integrated Classification of Pediatric Inflammatory Diseases, Based on the Concepts of Autoinflammation and the Immunological Disease Continuum

(2009) Dennis McGonagle et al.   PEDIATRIC RESEARCH

CD4+CD25+ regulatory T cells in human lupus erythematosus

(2008) Annegret Kuhn et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Analysis of the interindividual conservation of T cell receptor α- and β-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus

(2008) W. Luo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Memory B cells in common variable immunodeficiency: Clinical associations and sex differences

(2008) Silvia Sánchez-Ramón et al.   CLINICAL IMMUNOLOGY

Abatacept: a T-cell co-stimulation modulator for the treatment of rheumatoid arthritis

(2008) Andrew J K Östör   CLINICAL RHEUMATOLOGY

Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency—lessons learned from monogenic disorders in mice and men

(2008) Lisa S Westerberg et al.   CURRENT OPINION IN IMMUNOLOGY

Cytokines that regulate autoimmunity

(2008) Caroline Diveu et al.   CURRENT OPINION IN IMMUNOLOGY

Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands

(2008) M LOWENBERG et al.   STEROIDS

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics