Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Drug Exposure

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

(2018) Thomas M. Polasek et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Advancing tuberculosis drug regimen development through innovative quantitative translational pharmacology methods and approaches

(2017) Debra Hanna et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Precision dosing of targeted anticancer drugs—challenges in the real world

(2017) Hannah Yejin Kim et al.   Translational Cancer Research

Role of pharmacokinetic modeling and simulation in precision dosing of anticancer drugs

(2017) Adam S. Darwich et al.   Translational Cancer Research

Physiologically based pharmacokinetic modeling in regulatory decision-making at the European Medicines Agency

(2016) E Luzon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure

(2016) Andrew Rowland et al.   Expert Opinion on Drug Metabolism & Toxicology

Novel approaches to address challenges in global drug development

(2015) BP Smith et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

(2012) Sravanthi Cheeti et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions

(2012) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

(2009) Karen Rowland Yeo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Applications of Computer-Aided Pharmacokinetic and Pharmacodynamic Methods from Drug Discovery Through Registration

(2008) John Gibbs et al.   Current Computer-Aided Drug Design