Article
Nutrition & Dietetics
Marta Sierra-Cruz, Alba Miguens-Gomez, Carme Grau-Bove, Esther Rodriguez-Gallego, Mayte Blay, Montserrat Pinent, Anna Ardevol, Ximena Terra, Raul Beltran-Debon
Summary: Obesity and aging are global concerns, with adaptive homeostasis compromised in the elderly. Grape-seed proanthocyanidin extract (GSPE) may be effective in ameliorating these issues, especially in young animal models. This study confirmed that simultaneous administration of GSPE can improve metabolic disruptions caused by an obesogenic diet in aged rats.
Article
Polymer Science
Kummara Madhusudana Rao, Hyeon Jin Kim, Soyeon Won, Soon Mo Choi, Sung Soo Han
Summary: Cell-cultured meat, made from in vitro cultivation of animal-derived cells, has gained attention as a potential protein source for the future. Porous hydrogels, acting as artificial extracellular matrix, were studied for their effects on the growth and adhesion of bovine satellite muscle cells. The edible gelatin-based hydrogels, supplemented with grape seed extract, showed favorable characteristics and supported the growth of muscle cells, indicating their potential use in cell growth for cultured meat.
Article
Food Science & Technology
Marta Sierra-Cruz, Alba Miguens-Gomez, Esther Rodriguez-Gallego, Claudio D'Addario, Martina Di Bartolomeo, M. Teresa Blay, Montserrat Pinent, Raill Beltran-Debon, Ximena Terra
Summary: Diet-induced changes in the intestinal barrier and gut microbiota lead to the translocation of lipopolysaccharide (LPS) from the lumen to the lamina propria through different mechanisms, resulting in metabolic endotoxemia. The study evaluated the role of grape seed proanthocyanidin extract (GSPE) in modulating LPS translocation and the underlying mechanisms using in vitro and in vivo experiments. GSPE was found to regulate intestinal permeability by modulating receptor-mediated endocytosis and the interaction between gut microbiota and the endocannabinoid system through epigenetic mechanisms. These findings suggest that GSPE can improve intestinal dysfunction and metabolic endotoxemia caused by a high-fat diet.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Guisantes-Batan, Lorena Mazuecos, Blanca Rubio, Gema Pereira-Caro, Jose Manuel Moreno-Rojas, Antonio Andres, Sergio Gomez-Alonso, Nilda Gallardo
Summary: Regular consumption of grape seed extract (GSE) has beneficial effects on hepatic glucose and lipid metabolism. GSE activates AMPK and modulates the expression of ChREBP beta and PPAR beta/delta to improve liver function.
Review
Engineering, Chemical
Talita Arrais Daniel Mendes, Samuel Chillavert Dias Pascoal, Maria Clara Ayres Estellita, Marcelo Victor Sidou Lemos, Paulo Goberla de Barros Silva, Juliano Sartori Mendonca
Summary: This study evaluated the use of grape seed extract in the stability of restorations with resinous composites in dentin through a review and meta-analysis. It was found that as a pretreatment, grape seed extract improves bonding stability, but when incorporated with phosphoric acid, it decreases stability compared to the control group.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2022)
Article
Cell Biology
Rossana Cuciniello, Francesco Di Meo, Maria Sulli, Olivia Costantina Demurtas, Mirella Tanori, Mariateresa Mancuso, Clizia Villano, Riccardo Aversano, Domenico Carputo, Alfonso Baldi, Gianfranco Diretto, Stefania Filosa, Stefania Crispi
Summary: Grapevine seeds contain polyphenols that can induce apoptosis and inhibit cancer properties in mesothelioma cells, possibly due to the presence of oligomeric proanthocyanidins. MDM2 was identified as a potential molecular target of AGS, and it was found to act in both a p53-dependent and independent manner. AGS significantly inhibited tumor progression in a mouse model of mesothelioma.
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Beatrice Bonafos, Christine Feillet-Coudray, Francois Casas, Francisca Isabel Bravo, Enrique Calvo, Javier Avila-Roman, Miquel Mulero
Summary: Polyphenols play a key role in regulating circadian rhythms, while the cafeteria diet disrupts liver biological rhythm and increases ROS production. This study investigated the effects of grape seed proanthocyanidin extract (GSPE) on restoring the antioxidant balance and circadian rhythm in rats fed a cafeteria diet. GSPE treatment recovered the disrupted circadian rhythm, increased the peak expression of Sod1, and corrected altered hepatic metabolites. The timing of GSPE administration also showed a chronotherapeutic effect on its antioxidant properties.
Article
Nutrition & Dietetics
Christiane Schoen, Pietro Allegrini, Karin Engelhart-Jentzsch, Antonella Riva, Giovanna Petrangolini
Summary: Maintaining healthy blood pressure is crucial in preventing cardiovascular diseases, and natural substances can be helpful for hypertension. Grape seed extract has been shown to modulate vascular inflammation and blood pressure, with potential benefits for mood comfort and stress perception.
Article
Biotechnology & Applied Microbiology
Alyaa Farid, Dina Mohamed, Dina Mostafa, Rawan Tarek, Viola Sherif, Gehan Safwat
Summary: This study investigates the effectiveness of grape seed extract nanoparticles in protecting against amikacin-induced kidney injury. The results show that grape seed extract nanoparticles reduce oxidative stress and inflammation, and have a protective effect on the kidneys.
Review
Pharmacology & Pharmacy
Zarko Kulic, Martin D. Lehner, Gunnar P. H. Dietz
Summary: The phytochemical composition of extracts derived from the same plant can vary significantly, affecting their pharmacokinetic and pharmacodynamic properties, and ultimately their clinical efficacy and safety. Regulating active constituent levels and reducing undesired substances is vital for ensuring the quality and consistency of herbal extracts. The heterogeneity of extracts should be carefully considered when evaluating the efficacy and safety of plant-derived remedies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tianyou Wang, Qianqian Fan, Jiaxu Hong, Zhan Chen, Xujiao Zhou, Jianhua Zhang, Yiqin Dai, Hao Jiang, Zhipeng Gu, Yiyun Cheng, Yiwen Li
Summary: The study reports a direct fabrication strategy towards polyphenol nanoparticles with tunable size, excellent biocompatibility, and reactive oxygen species (ROS) scavenging capacities from grape seed via an enzymatic polymerization method. The resulting nanoparticles can efficiently prevent cell damage from ROS and exert promising in vivo antioxidant therapeutic effects on several oxidative stress-related diseases. This research can stimulate the development of more kinds of low-cost, safe, and efficient biomass-based antioxidative nanomaterials via similar fabrication methodologies.
Article
Food Science & Technology
Pufan Zheng, Mei Zhang, Xin Fang, Lili Tang, Zhixue Wang, Fuchen Shi
Summary: This study identified and quantified metabolites in three pear species using a targeted LC-MS/MS approach. The results showed distinct differences in metabolite composition between cultivars, and identified metabolic pathways related to fruit quality. D-xylose, formononetin, procyanidin A1 and beta-nicotinamide mononucleotide were identified as major differentially expressed metabolites.
Article
Horticulture
Yuying Ma, Zhen Gao, Wensheng Du, Fei Xie, Guikuan Ren, Meiling Tang, Qiuling Zheng, Hui Kang, Yuanpeng Du
Summary: 'Ruidu kemei' (Kemei) is a new variety of rose-scented grape that was selected from among the hybrid offspring of 'Italy' x 'Muscat Louis'. Bagging was found to increase the total soluble solid (TSS) content and sugar-acid ratio in Kemei grapes, but had no significant effect on titratable acid (TA) levels. Metabolomic and RNA sequencing analysis revealed differentially accumulated metabolites and expressed genes between bagged and natural-light samples, indicating the involvement of starch and sucrose metabolic pathways, glycolysis, and the tricarboxylic acid (TCA) cycle in bagging-induced changes. These findings contribute to a comprehensive understanding of the molecular and metabolic mechanisms underlying the effects of fruit bagging on Kemei grape quality formation.
SCIENTIA HORTICULTURAE
(2023)
Article
Food Science & Technology
Carolina Munoz-Gonzalez, Celia Criado, Maria Perez-Jimenez, Maria angeles Pozo-Bayon
Summary: The study demonstrates that the addition of tannin extracts can significantly influence the release and perception of ethyl hexanoate in wine, but not ethyl decanoate. The components of tannin extracts may interact with the compound directly or through complex formation with oral components, affecting its release and perception.
Article
Neurosciences
Ramin Mahdipour, Alireza Ebrahimzadeh-Bideskan, Mahmoud Hosseini, Sara Shahba, Giovanni Lombardi, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: Neurological disorders have a significant impact on global health, and grape seed extract shows potential as a valuable therapeutic agent due to its antioxidant, anti-inflammatory, and protein homeostasis maintenance properties.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Kenjiro Ono, Daisy Zhao, Qingli Wu, James Simon, Jun Wang, Aurelian Radu, Giulio Maria Pasinetti
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Psychiatry
Chad Smith, Kyle J. Trageser, Henry Wu, Francis J. Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinetti
Summary: Research on the impact of sleep deprivation on anxiety and anxiolytic properties reveals that a flavanol-rich dietary preparation can alleviate neuroimmune activation and reduce anxiety. Additionally, the study found that sleep deprivation alters the expression of circadian genes, leading to changes in NLRP3 expression and IL-1 beta production.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Sebastian-Valverde, Henry Wu, Md Al Rahim, Roberto Sanchez, Kunal Kumar, Robert J. De Vita, Giulio Maria Pasinetti
Summary: Inflammasomes are involved in host response to danger signals, with potential therapeutic implications for autoimmune diseases, diabetes, and neurodegenerative disorders. Inhibiting the ATPase activity of NLRP3 disrupts inflammasome function, highlighting the need for new compounds with therapeutic potential. Computational modeling and virtual screening identified novel compounds as potential NLRP3 inhibitors, setting the basis for rational design of inflammasome-targeting drugs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Aurelie Bechoff, Apurba Shee, Brighton M. Mvumi, Patrick Ngwenyama, Hawi Debelo, Mario G. Ferruzzi, Loveness K. Nyanga, Sarah Mayanja, Keith I. Tomlins
Summary: Postharvest losses (PHLs) have a significant impact on food security and nutrient availability in low- and middle-income countries. This study developed a methodology and tool to estimate nutritional postharvest losses (NPHLs) for various food commodities in sub-Saharan Africa. The findings suggest that reducing PHLs along food value chains could greatly improve access to nutritious food for vulnerable populations.
Review
Agriculture, Multidisciplinary
Mary Ann Lila, Roberta Targino Hoskin, Mary H. Grace, Jia Xiong, Renee Strauch, Mario Ferruzzi, Massimo Iorizzo, Colin Kay
Summary: Protein-polyphenol aggregate particles can enhance the health effects of functional food products. Evidence suggests that the complexation of polyphenolic compounds can protect them during transit in the gastrointestinal tract, allowing them to exert their health benefits in the colon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
John R. N. Taylor, Mario G. Ferruzzi, Cheikh Ndiaye, Djibril Traor, Violet K. Mugalavai, Hugo De Groote, Cheryl O. ' Brien, Timothy J. Rendall, Bruce R. Hamaker
Summary: Small and micro food enterprises are important partners for fortification strategies to address micronutrient deficiencies in low-income countries. This paper discusses Entrepreneur-led Food Fortification (ElFF), which involves collaborations between US and African food and nutrition R&D organizations and African small-scale food processors. ElFF can overcome challenges faced by these enterprises and achieve business scale and nutritional impact through providing value propositions, product distribution and marketing. The example of entrepreneur-led production of fortified grain-based instant porridge flour illustrates a framework for successful implementation of ElFF in local markets and government nutrition strategies.
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Michael P. Dzakovich, Hawi Debelo, Marc C. Albertsen, Ping Che, Todd J. Jones, Marissa K. Simon, Zuo-Yu Zhao, Kimberly Glassman, Mario G. Ferruzzi
Summary: Vitamin A, iron, and zinc deficiencies are common in sub-Saharan Africa, particularly among women and children. Biotechnology has been used to enhance the content and bioaccessibility of provitamin A carotenoids and minerals in staple crops, but the simultaneous enhancement of both carotenoids and minerals has not been thoroughly studied. This research evaluated genetically engineered constructs containing heterologous genes to improve carotenoid stability and pathway flux, and phytase to increase mineral bioaccessibility. The results showed significant increases in carotenoid content and improved mineral bioaccessibility in the transgenic events compared to control groups. These findings suggest that combined approaches to enhance micronutrient content and bioaccessibility are feasible and should be further studied in human trials.
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Zulfiqar Mohamedshah, Sydney Chadwick-Corbin, Roberta Hoskin, Massimo Iorizzo, Mary Ann Lila, Andrew P. Neilson, Mario G. Ferruzzi
Summary: Insights into the impact of food matrix factors on the bioavailability of bioactive carotenoids and chlorophylls from fruits and vegetables are crucial. In vitro models were used to assess the stability, bioaccessibility, and intestinal absorption of carotenoids and chlorophylls in different forms of spinach. The results showed that spinach forms created by various drying technologies deliver similar levels of bioaccessible bioactives, and the lower gastrointestinal tract may play a significant role in the absorption of these compounds.
Article
Biochemistry & Molecular Biology
Zulfiqar Mohamedshah, Micaela Hayes, Sydney Chadwick-Corbin, Andrew P. Neilson, Mario G. Ferruzzi
Summary: The study compared the bioavailability and metabolism of phenolics between grapes and grape juice. It found that phenolics in grape juice were more easily absorbed compared to whole grapes. However, overall, the absorbable phenolics from 100% grape juice were similar to those from whole grapes, suggesting that consuming whole fruit and juice may have similar health benefits.
Article
Biochemistry & Molecular Biology
Olivia G. L. Coelho, Rita de Cassia G. Alfenas, Hawi Debelo, JoLynne D. Wightman, Mario G. Ferruzzi, Richard D. Mattes
Summary: This study found that beverages with customary flavor essence (CGJ and LP) consumed with a meal can reduce hunger, appetite, and prospective consumption, while consumption of a low polyphenolic content beverage with reduced flavor essence is associated with higher 24-hour blood glucose levels. When consumed alone, CGJ can lower glycemic responses in individuals excreting higher concentrations of phenolic metabolite, but beverages without CG polyphenols and reduced flavor essence lead to higher blood glucose responses in individuals excreting higher concentrations of caffeic acid-O-sulfate.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Sydney Corbin, Candace Nunn, Marti Pottorff, Colin D. Kay, Mary Ann Lila, Massimo Iorrizo, Mario G. Ferruzzi
Summary: The study investigated the impact of genetic differences and various processing methods on the bioaccessibility of carotenoids and chlorophylls in spinach. Results showed that both genotype and processing techniques significantly influenced the bioaccessibility of these phytochemicals, with juicing having the lowest bioaccessibility and blanching having the highest.
Article
Biochemistry & Molecular Biology
Dennis P. Cladis, Abigayle M. R. Simpson, Kaitlyn J. Cooper, Cindy H. Nakatsu, Mario G. Ferruzzi, Connie M. Weaver
Summary: Research suggests that consuming polyphenol-rich fruits and vegetables, such as blueberries, is beneficial for health. However, the effects of polyphenols from dietary supplements on gut microbiota and phenolic metabolism are still unclear. It has been found that blueberry polyphenols in fruit and supplements lead to differences in gut microbial communities and phenolic metabolism.
Review
Food Science & Technology
Johanita Kruger, John R. N. Taylor, Mario G. Ferruzzi, Hawi Debelo
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2020)
Article
Biochemistry & Molecular Biology
Zulfiqar Mohamedshah, Sydney Chadwick-Corbin, JoLynne D. Wightman, Mario G. Ferruzzi
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
