Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia
出版年份 2018 全文链接
标题
Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia
作者
关键词
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出版物
ChemMedChem
Volume 13, Issue 10, Pages 988-1003
出版商
Wiley
发表日期
2018-02-28
DOI
10.1002/cmdc.201700783
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mass spectrometric characterization of the hypoxia-inducible factor (HIF) stabilizer drug candidate BAY 85-3934 (molidustat) and its glucuronidated metabolite BAY-348, and their implementation into routine doping controls
- (2016) Josef Dib et al. Drug Testing and Analysis
- Biocatalysis at Work: Applications in the Development of Sagopilone
- (2015) Kathrin Gottfried et al. ChemMedChem
- HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
- (2015) Patrick H. Maxwell et al. Nature Reviews Nephrology
- Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
- (2014) Ingo Flamme et al. PLoS One
- Cardiovascular Toxicity of Epoetin-Alfa in Patients with Chronic Kidney Disease
- (2013) Peter A. McCullough et al. AMERICAN JOURNAL OF NEPHROLOGY
- Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters
- (2013) Michael D. Shultz BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Emerging technologies for metabolite generation and structural diversification
- (2013) Kevin P. Cusack et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses
- (2013) Michael H. Rabinowitz JOURNAL OF MEDICINAL CHEMISTRY
- Hypoxia-Inducible Factors in Physiology and Medicine
- (2012) Gregg L. Semenza CELL
- Inhibition of 2-oxoglutarate dependent oxygenases
- (2011) Nathan R. Rose et al. CHEMICAL SOCIETY REVIEWS
- HIF prolyl hydroxylase inhibitors for anemia
- (2011) Eugene Muchnik et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Microbial production of phase I and phase II metabolites of midazolam
- (2011) Cyrille Marvalin et al. XENOBIOTICA
- Regulation of erythropoietin production
- (2010) Wolfgang Jelkmann JOURNAL OF PHYSIOLOGY-LONDON
- Natural Products Version 2.0: Connecting Genes to Molecules
- (2010) Christopher T. Walsh et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Erythropoiesis-Stimulating Agents — Time for a Reevaluation
- (2010) Ellis F. Unger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Microbial production of phase I and phase II metabolites of propranolol
- (2010) Cyrille Marvalin et al. XENOBIOTICA
- Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes
- (2010) Andy Zöllner et al. Bioanalysis
- Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe
- (2009) C.-A. Dragan et al. DRUG METABOLISM AND DISPOSITION
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