Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline

(2018) Tetiana Druzhenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 6-Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery

(2017) Bohdan A. Chalyk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery

(2017) Aleksandr V. Denisenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Peptidyl-Prolyl Model Study: How Does the Electronic Effect Influence the Amide Bond Conformation?

(2017) Pavel K. Mykhailiuk et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of a polyproline structure with hydrophobic exterior using octahydroindole-2-carboxylic acid

(2017) Vladimir Kubyshkin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?

(2016) Daniel J. Foley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

(2016) James A. Bull et al.   CHEMICAL REVIEWS

Strain-release amination

(2016) R. Gianatassio et al.   SCIENCE

Designing novel building blocks is an overlooked strategy to improve compound quality

(2015) Frederick W. Goldberg et al.   DRUG DISCOVERY TODAY

Design, Synthesis, and Characterization of SO2-Containing Azabicyclo[3.n.1]alkanes: Promising Building Blocks for Drug Discovery

(2015) Tetiana Druzhenko et al.   ORGANIC LETTERS

Bespoke SnAP Reagents for the Synthesis of C-Substituted Spirocyclic and Bicyclic Saturated N-Heterocycles

(2015) Kimberly Geoghegan et al.   ORGANIC LETTERS

Stereoselective Reactions in Preparation of Chiral α-Hetera­spiro[m.n]alkanes

(2015) Kjell Undheim   SYNTHESIS-STUTTGART

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

One-Step Synthesis of Saturated Spirocyclic N-Heterocycles with Stannyl Amine Protocol (SnAP) Reagents and Ketones

(2014) Woon-Yew Siau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

(2014) Joanna Wlochal et al.   ORGANIC LETTERS

Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space

(2013) Sarvesh Kumar et al.   JOURNAL OF ORGANIC CHEMISTRY

Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from N-Substituted Homopropargyl Alcohols

(2013) Thomas O. Painter et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes

(2013) Dong Bo Li et al.   ORGANIC LETTERS

Trianion Synthon Approach to Spirocyclic Heterocycles

(2013) Matthew A. Perry et al.   ORGANIC LETTERS

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New and unusual scaffolds in medicinal chemistry

(2011) Charles M. Marson   CHEMICAL SOCIETY REVIEWS

Synthesis of Novel Angular Spirocyclic Azetidines

(2011) Carine Guérot et al.   ORGANIC LETTERS

Synthesis of Novel Azaspiro[3.4]octanes as Multifunctional Modules in Drug Discovery

(2011) Dong Bo Li et al.   ORGANIC LETTERS

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

(2011) Johannes A. Burkhard et al.   ORGANIC LETTERS

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclobutane-Derived Diamines: Synthesis and Molecular Structure

(2010) Dmytro S. Radchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

(2010) Aleksandr V. Denisenko et al.   ORGANIC LETTERS

Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

(2010) Johannes A. Burkhard et al.   ORGANIC LETTERS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Fluoro-2,4-methanoproline

(2009) Anton N. Tkachenko et al.   ORGANIC LETTERS

The Mechanism of the Ketene−Imine (Staudinger) Reaction in Its Centennial: Still an Unsolved Problem?

(2008) Fernando P. Cossío et al.   ACCOUNTS OF CHEMICAL RESEARCH

Spirocyclic Oxetanes: Synthesis and Properties

(2008) Georg Wuitschik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation of β-lactams by [2+2] cycloaddition of ketenes and imines

(2008) Nanyan Fu et al.   TETRAHEDRON

Hugo (Ugo) Schiff, Schiff Bases, and a Century of β-Lactam Synthesis

(2007) Thomas T. Tidwell   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION