Journal
ORGANIC LETTERS
Volume 17, Issue 8, Pages 1934-1937Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00618
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Funding
- European Research Council (ERC) [306793-CASAA]
- ERC Proof of Concept Grant [620214-SnAP]
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The precise placement of C-substituents on bicyclic and spirocyclic N-heterocycles is readily achieved by the combination of aldehydes and new SnAP reagents. The substituted SnAP reagents are readily prepared from simple starting materials and couple with a variety of aromatic and heteroaromatic aldehydes at room temperature under operationally simple conditions to deliver substituted morpholine and piperazine products.
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