Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives as Tubulin Polymerization Inhibitor

Novel isochroman-triazoles and thiadiazole hybrids: Design, synthesis and antimicrobial activity

(2017) Aamer Saeed et al.   Journal of Saudi Chemical Society

Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazole-3-thione/thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity

(2016) Alieh Ameri et al.   ARCHIV DER PHARMAZIE

Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

(2016) Li-Yuan Zhang et al.   CHINESE CHEMICAL LETTERS

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

(2015) Arvind S. Negi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues

(2015) Adam Huczyński et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation

(2015) Zhiyong Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial, antibiotic potentiating activity and phytochemical profile of essential oils from exotic and endemic medicinal plants of Mauritius

(2015) Z. Aumeeruddy-Elalfi et al.   INDUSTRIAL CROPS AND PRODUCTS

Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

(2015) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking

(2014) Miao-miao Niu et al.   ACTA PHARMACOLOGICA SINICA

Fruitful Decade for Antileishmanial Compounds from 2002 to Late 2011

(2014) Hidayat Hussain et al.   CHEMICAL REVIEWS

Synthesis of novel 1,2,4-triazoles, triazolothiadiazines and triazolothiadiazoles as potential anticancer agents

(2014) Mona M. Kamel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives

(2013) Amir Assadieskandar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An insight into synthetic Schiff bases revealing antiproliferative activities in vitro

(2013) Krzysztof Sztanke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC)

(2013) Chul-Ho Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3( Z )-hexen-1,5-diynes as a new class of potent antitumor agents

(2013) Yu-Hsiang Lo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs

(2013) Mandana Banimustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of a Schiff base scaffold, N-(2-hydroxy acetophenone) glycinate-in overcoming multidrug resistance in cancer

(2013) Avishek Ganguly et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site

(2013) Chenxiao Da et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

(2013) Aleem Gangjee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular modeling studies of novel heterocyclic compounds as anti-proliferative agents

(2013) Anurag Chaudhary et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, experimental, theoretical characterization and biological activities of 4-ethyl-5-(2-hydroxyphenyl)-2H-1,2,4-triazole-3(4H)-thione

(2013) Metin Koparir et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents

(2012) Ting-Ting Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents

(2012) Romeo Romagnoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety

(2012) Pei-Liang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

(2012) Aroke S. Ahmed et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quantum chemical investigation of the intra- and intermolecular proton transfer reactions and hydrogen bonding interactions in 4-amino-5-(2-hydroxyphenyl)-2H-1,2,4-triazole-3(4H)-thione

(2012) Namık Özdemir   JOURNAL OF MOLECULAR MODELING

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents

(2011) Yang Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

cis-trans Isomerisation of Substituted Aromatic Imines: A Comparative Experimental and Theoretical Study

(2011) Ying Luo et al.   CHEMPHYSCHEM

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe

(2011) Niamh M. O’Boyle et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives

(2010) Romeo Romagnoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of substituted-phenyl-1,2,4-triazol-3-thione analogues with modified d-glucopyranosyl residues and their antiproliferative activities

(2009) Zhizhang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Quantum chemical investigation of intramolecular thione-thiol tautomerism of 1,2,4-triazole-3-thione and its disubstituted derivatives

(2009) Mehdi D. Davari et al.   JOURNAL OF MOLECULAR MODELING

Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives

(2007) Krzysztof Sztanke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY