Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazole-3-thione/thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity

Synthesis, antifungal evaluation and in silico study of novel Schiff bases derived from 4-amino-5(3,5-dimethoxy-phenyl)- 4H -1,2,4-triazol-3-thiol

(2017) N.S. Hari Narayana Moorthy et al.   Arabian Journal of Chemistry

Novel isochroman-triazoles and thiadiazole hybrids: Design, synthesis and antimicrobial activity

(2017) Aamer Saeed et al.   Journal of Saudi Chemical Society

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

(2015) Arvind S. Negi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 5,6,7-trimethoxy-1-benzylidene-3,4-dihydro-naphthalen-2-one as tubulin-polymerization inhibitors

(2015) Jun-Hang Jiang et al.   CHINESE CHEMICAL LETTERS

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents

(2015) Narsimha Reddy Penthala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances bioactive 1,2,4-triazole-3-thiones

(2015) Ş.Güniz Küçükgüzel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation

(2015) Zhiyong Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial, antibiotic potentiating activity and phytochemical profile of essential oils from exotic and endemic medicinal plants of Mauritius

(2015) Z. Aumeeruddy-Elalfi et al.   INDUSTRIAL CROPS AND PRODUCTS

Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking

(2014) Miao-miao Niu et al.   ACTA PHARMACOLOGICA SINICA

Synthesis, Cytotoxicity, Docking Study, and Tubulin Polymerization Inhibitory Activity of Novel 1-(3,4-Dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxanilides

(2014) Omar M. Aly et al.   ARCHIV DER PHARMAZIE

Schiff’s base derivatives bearing nitroimidazole and quinoline nuclei: New class of anticancer agents and potential EGFR tyrosine kinase inhibitors

(2014) Jigar A. Makawana et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Synthesis of Aminostilbene-Arylpropenones as Tubulin Polymerization Inhibitors

(2014) Ahmed Kamal et al.   ChemMedChem

New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

(2014) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand

(2014) Niamh M. O’Boyle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Antimitotic and Antivascular Activity of 1-(3′,4′,5′-Trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles

(2014) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents

(2014) Adil A. Othman et al.   Arabian Journal of Chemistry

An insight into synthetic Schiff bases revealing antiproliferative activities in vitro

(2013) Krzysztof Sztanke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3( Z )-hexen-1,5-diynes as a new class of potent antitumor agents

(2013) Yu-Hsiang Lo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs

(2013) Mandana Banimustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nonclassical antifolates, part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study

(2013) Ghada S. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors

(2013) Lívia B. Salum et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site

(2013) Chenxiao Da et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular modeling studies of novel heterocyclic compounds as anti-proliferative agents

(2013) Anurag Chaudhary et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, experimental, theoretical characterization and biological activities of 4-ethyl-5-(2-hydroxyphenyl)-2H-1,2,4-triazole-3(4H)-thione

(2013) Metin Koparir et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety

(2012) Pei-Liang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone

(2012) Nithinchandra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

(2012) Aroke S. Ahmed et al.   JOURNAL OF ETHNOPHARMACOLOGY

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents

(2011) Yang Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Tubulin Colchicine Domain: a Molecular Modeling Perspective

(2011) Alberto Massarotti et al.   ChemMedChem

Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds

(2011) Alexandre Novoa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

What tubulin drugs tell us about microtubule structure and dynamics

(2011) Linda A. Amos   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives

(2010) Romeo Romagnoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors

(2010) Sahar Mahmoud Abou-Seri   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

(2009) S. Peri Aytaç et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells

(2008) Anelia Ts. Mavrova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives

(2007) Krzysztof Sztanke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY