Dendrimers in combination with natural products and analogues as anti-cancer agents

2016 FDA drug approvals

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Heterolayered hybrid dendrimers with optimized sugar head groups for enhancing carbohydrate–protein interactions

(2017) Rahul S. Bagul et al.   Polymer Chemistry

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo

(2017) I. Posadas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can dendrimer based nanoparticles fight neurodegenerative diseases? Current situation versus other established approaches

(2017) Serge Mignani et al.   PROGRESS IN POLYMER SCIENCE

The specific functionalization of cyclotriphosphazene for the synthesis of smart dendrimers

(2016) Anne-Marie Caminade et al.   DALTON TRANSACTIONS

A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration

(2016) XiuLing Xu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Sugar-modified poly(propylene imine) dendrimers as drug delivery agents for cytarabine to overcome drug resistance

(2016) Aleksandra Szulc et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A review on comparative study of PPI and PAMAM dendrimers

(2016) Daljeet Kaur et al.   JOURNAL OF NANOPARTICLE RESEARCH

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Dendrimer Prodrugs

(2016) Soraya da Silva Santos et al.   MOLECULES

Sugar-Modified Poly(propylene imine) Dendrimers Stimulate the NF-κB Pathway in a Myeloid Cell Line

(2016) Izabela Jatczak-Pawlik et al.   PHARMACEUTICAL RESEARCH

Low generation anionic dendrimers modulate islet amyloid polypeptide self-assembly and inhibit pancreatic β-cell toxicity

(2016) Phuong T. Nguyen et al.   RSC Advances

Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM)

(2015) Ying Liu et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges

(2015) Lin-ping Wu et al.   BIOCONJUGATE CHEMISTRY

Dendritic, Oligomeric, and Polymeric Self-Immolative Molecular Amplification

(2015) Michal E. Roth et al.   CHEMICAL REVIEWS

Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers

(2015) René Roy et al.   CHEMICAL SOCIETY REVIEWS

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

(2015) Dietmar Appelhans et al.   CHEMICAL SOCIETY REVIEWS

RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells

(2015) Xuedan He et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

There is no better time than the present: nanotechnology as a disruptive innovation for drug development

(2015) Charles Oo et al.   DRUG DISCOVERY TODAY

Targeted delivery of polyamidoamine-paclitaxel conjugate functionalized with anti-human epidermal growth factor receptor 2 trastuzumab

(2015) Pengkai Ma et al.   International Journal of Nanomedicine

In vivo delivery of siRNA to the brain by carbosilane dendrimer

(2015) Mª Jesús Serramía et al.   JOURNAL OF CONTROLLED RELEASE

Cationic phosphorus dendrimers and therapy for Alzheimer's disease

(2015) Tomasz Wasiak et al.   NEW JOURNAL OF CHEMISTRY

Encapsulation of doxorubicin within multifunctional gadolinium-loaded dendrimer nanocomplexes for targeted theranostics of cancer cells

(2015) Jingyi Zhu et al.   RSC Advances

Multifunctional Lactobionic Acid-Modified Dendrimers for Targeted Drug Delivery to Liver Cancer Cells: Investigating the Role Played by PEG Spacer

(2014) Fanfan Fu et al.   ACS Applied Materials & Interfaces

PAMAM Dendrimers Augment Inhibitory Effects of Curcumin on Cancer Cell Proliferation: Possible Inhibition of Telomerase

(2014) Mahdie Mollazade et al.   Asian Pacific Journal of Cancer Prevention

Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging

(2014) Mara Gonçalves et al.   BIOMACROMOLECULES

Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

(2014) Ornchuma Naksuriya et al.   BIOMATERIALS

Nanopharmaceuticals (part 1): products on the market

(2014) Volkmar Weissig et al.   International Journal of Nanomedicine

Combination of Dendrimer-Nanovector-Mediated Small Interfering RNA Delivery to Target Akt with the Clinical Anticancer Drug Paclitaxel for Effective and Potent Anticancer Activity in Treating Ovarian Cancer

(2014) Shashwati Kala et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

(2014) Longyan Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(amidoamine) Dendrimer–Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein

(2014) Mallory A. van Dongen et al.   MOLECULAR PHARMACEUTICS

Natural product and natural product derived drugs in clinical trials

(2014) Mark S. Butler et al.   NATURAL PRODUCT REPORTS

Synthesis and cytotoxic activity of G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells

(2014) Katarzyna Winnicka et al.   Pharmacological Reports

Cationic Poly-l-lysine Dendrimer Complexes Doxorubicin and Delays Tumor Growth in Vitro and in Vivo

(2013) Khuloud T. Al-Jamal et al.   ACS Nano

Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview

(2013) Serge Mignani et al.   ADVANCED DRUG DELIVERY REVIEWS

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Dendrimer Space Exploration: An Assessment of Dendrimers/Dendritic Scaffolding as Inhibitors of Protein–Protein Interactions, a Potential New Area of Pharmaceutical Development

(2013) Serge Mignani et al.   CHEMICAL REVIEWS

Potential Role of Naturally Derived Polyphenols and Their Nanotechnology Delivery in Cancer

(2013) Tasnima Khushnud et al.   MOLECULAR BIOTECHNOLOGY

Gold nanostars for superficial diseases: a promising tool for localized hyperthermia?

(2013) Giuseppe Chirico et al.   Nanomedicine

Novelty in the target landscape of the pharmaceutical industry

(2013) Pankaj Agarwal et al.   NATURE REVIEWS DRUG DISCOVERY

Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment

(2013) E. Blattes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

(2013) Serge Mignani et al.   PROGRESS IN POLYMER SCIENCE

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Synthesis and characterization of G5 PAMAM dendrimer containing daunorubicin for targeting cancer cells

(2012) Yuan Yue et al.   ARCHIVES OF PHARMACAL RESEARCH

Multi-Parameter Optimization: Identifying High Quality Compounds with a Balance of Properties

(2012) Matthew D. Segall   CURRENT PHARMACEUTICAL DESIGN

What is the most important approach in current drug discovery: doing the right things or doing things right?

(2012) Thomas Elebring et al.   DRUG DISCOVERY TODAY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers

(2012) Jongdoo Lim et al.   MOLECULAR PHARMACEUTICS

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Dendrimers Bind Antioxidant Polyphenols and cisPlatin Drug

(2012) Amine Abderrezak et al.   PLoS One

Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers

(2011) Andrew D. Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Gene Delivery into Mesenchymal Stem Cells: A Biomimetic Approach Using RGD Nanoclusters Based on Poly(amidoamine) Dendrimers

(2011) Deepti Pandita et al.   BIOMACROMOLECULES

Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy

(2011) Jinyao Liu et al.   BIOMACROMOLECULES

Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery

(2011) Jingjing Hu et al.   BIOMATERIALS

Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer–methotrexate conjugate as a potential anticancer agent

(2011) Yuehua Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Non-Viral Gene Delivery to Mesenchymal Stem Cells: Methods, Strategies and Application in Bone Tissue Engineering and Regeneration

(2011) Jose L. Santos et al.   CURRENT GENE THERAPY

Curcumin nanoformulations: a future nanomedicine for cancer

(2011) Murali M. Yallapu et al.   DRUG DISCOVERY TODAY

Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

(2011) Chen Zhao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin–PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)

(2011) Yulei Chang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker

(2011) Lisa M. Kaminskas et al.   JOURNAL OF CONTROLLED RELEASE

Lactoferrin-Conjugated Dendritic Nanoconstructs for Lung Targeting of Methotrexate

(2011) Balak D. Kurmi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dendritic Poly(ethylene glycol) Bearing Paclitaxel and Alendronate for Targeting Bone Neoplasms

(2011) Chiara Clementi et al.   MOLECULAR PHARMACEUTICS

A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells

(2011) Yu-Ling Lin et al.   Nanomedicine-Nanotechnology Biology and Medicine

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems

(2011) Lisa M. Kaminskas et al.   Nanomedicine-Nanotechnology Biology and Medicine

Dendrimer therapeutics: covalent and ionic attachments

(2011) Saïd El Kazzouli et al.   NEW JOURNAL OF CHEMISTRY

Targeted delivery of doxorubicin into cancer cells using a folic acid–dendrimer conjugate

(2011) Yin Wang et al.   Polymer Chemistry

Bioanalytical method development for a generation 5 polyamidoamine folic acid methotrexate conjugated nanoparticle

(2010) Leon van Haandel et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors

(2010) Hai He et al.   BIOMATERIALS

Glycopeptide dendrimer colchicine conjugates targeting cancer cells

(2010) Emma M.V. Johansson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery

(2010) Thommey P. Thomas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biomedical applications of dendrimers: a tutorial

(2010) Meredith A. Mintzer et al.   CHEMICAL SOCIETY REVIEWS

Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

(2010) William C. Floyd et al.   ChemMedChem

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs

(2010) Liang Ouyang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug delivery using multifunctional dendrimers and hyperbranched polymers

(2010) Constantinos M Paleos et al.   Expert Opinion on Drug Delivery

Dendrimer toxicity: Let's meet the challenge

(2010) Keerti Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

(2010) José L. Santos et al.   JOURNAL OF CONTROLLED RELEASE

Relevance of folic acid/polymer ratio in targeted PEG–epirubicin conjugates

(2010) Fabiana Canal et al.   JOURNAL OF CONTROLLED RELEASE

G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity

(2010) Deborah S. Goldberg et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated PAMAM dendrimers as a potential drug delivery carrier:in vitroandin vivocomparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex

(2010) Yan-Yan Jiang et al.   JOURNAL OF DRUG TARGETING

Biological Assessment of Triazine Dendrimer: Toxicological Profiles, Solution Behavior, Biodistribution, Drug Release and Efficacy in a PEGylated, Paclitaxel Construct

(2010) Su-Tang Lo et al.   MOLECULAR PHARMACEUTICS

Receptor-Mediated Gene Delivery Using PAMAM Dendrimers Conjugated with Peptides Recognized by Mesenchymal Stem Cells

(2010) José L. Santos et al.   MOLECULAR PHARMACEUTICS

Capping Methotrexate α-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers

(2010) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study

(2010) Delia Soto-Castro et al.   MOLECULES

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Biological properties of phosphorus dendrimers

(2010) Anne-Marie Caminade et al.   NEW JOURNAL OF CHEMISTRY

Self-immolative dendrimers: A distinctive approach to molecular amplification

(2010) Michal Avital-Shmilovici et al.   Soft Matter

Natural products for cancer chemotherapy

(2010) Arnold L. Demain et al.   Microbial Biotechnology

Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo

(2009) Andrzej Myc et al.   ANTI-CANCER DRUGS

Lamellarin D Bioconjugates II: Synthesis and Cellular Internalization of Dendrimer and Nuclear Location Signal Derivatives

(2009) Daniel Pla et al.   BIOCONJUGATE CHEMISTRY

Enzymatic activation of hydrophobic self-immolative dendrimers: The effect of reporters with ionizable functional groups

(2009) Michal Avital-Shmilovici et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dendrimers as Carriers for Delivery of Chemotherapeutic Agents

(2009) Scott H. Medina et al.   CHEMICAL REVIEWS

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids

(2009) G. Leonarduzzi et al.   CURRENT MEDICINAL CHEMISTRY

Natural product scaffolds as leads to drugs

(2009) David J Newman et al.   Future Medicinal Chemistry

Challenges in the Search for Drugs to Treat Central Nervous System Disorders

(2009) S. J. Enna et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthesis andIn VivoAntitumor Efficacy of PEGylated Poly(l-lysine) Dendrimer−Camptothecin Conjugates

(2009) Megan E. Fox et al.   MOLECULAR PHARMACEUTICS

Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective

(2009) Mélanie Auffan et al.   Nature Nanotechnology

PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation

(2009) Saijie Zhu et al.   PHARMACEUTICAL RESEARCH

Therapeutic and diagnostic applications of dendrimers for cancer treatment☆

(2008) J WOLINSKY et al.   ADVANCED DRUG DELIVERY REVIEWS

Dendrimers in Oncology: An Expanding Horizon

(2008) Rakesh Kumar Tekade et al.   CHEMICAL REVIEWS

Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

(2008) Yiyun Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors

(2008) José Luís Santos et al.   JOURNAL OF CONTROLLED RELEASE

Surface-engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy

(2008) Rakesh Kumar Tekade et al.   JOURNAL OF DRUG TARGETING

Methotrexate Loaded Polyether-Copolyester Dendrimers for the Treatment of Gliomas: Enhanced Efficacy and Intratumoral Transport Capability

(2008) Renu Singh Dhanikula et al.   MOLECULAR PHARMACEUTICS

HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb

(2008) Rameshwer Shukla et al.   NANOTECHNOLOGY

Translational research: Crossing the valley of death

(2008) Declan Butler   NATURE

Synthesis of Water-Soluble Dendrimers Based on Melamine Bearing 16 Paclitaxel Groups

(2007) Jongdoo Lim et al.   ORGANIC LETTERS