Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation

(2014) Michiel van de Waterbeemd et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteome Adaptation of Saccharomyces cerevisiae to Severe Calorie Restriction in Retentostat Cultures

(2014) Nadine A. Binai et al.   JOURNAL OF PROTEOME RESEARCH

Covalent Labeling with Isotopically Encoded Reagents for Faster Structural Analysis of Proteins by Mass Spectrometry

(2013) Yuping Zhou et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules

(2013) Lars Konermann et al.   ANALYTICAL CHEMISTRY

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

(2013) Nicholas J. Clark et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting

(2013) Galahad Deperalta et al.   mAbs

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

(2013) Rebecca J. Rose et al.   mAbs

Antibody-drug conjugates

(2013) Alain Beck et al.   mAbs

Methods for site-specific drug conjugation to antibodies

(2013) Christopher R Behrens et al.   mAbs

Small-molecule ligand docking into comparative models with Rosetta

(2013) Steven A Combs et al.   Nature Protocols

Maturing antibody–drug conjugate pipeline hits 30

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting

(2012) Caroline Watson et al.   AAPS Journal

Revisiting the Role of Glycosylation in the Structure of Human IgG Fc

(2012) M. Jack Borrok et al.   ACS Chemical Biology

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

(2012) Sara Rosati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Drug Conjugates for the Treatment of Cancer

(2012) John A. Flygare et al.   Chemical Biology & Drug Design

Antibody–drug conjugates: Basic concepts, examples and future perspectives

(2012) Giulio Casi et al.   JOURNAL OF CONTROLLED RELEASE

Influence of the Cosolute Environment on IgG Solution Structure Analyzed by Small-Angle X-ray Scattering

(2012) Wayne G. Lilyestrom et al.   JOURNAL OF PHYSICAL CHEMISTRY B

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Antibody Conjugate Therapeutics: Challenges and Potential

(2011) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

(2011) Rebecca J. Rose et al.   STRUCTURE

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Partial Acetylation of Lysine Residues Improves Intraprotein Cross-Linking

(2008) Xin Guo et al.   ANALYTICAL CHEMISTRY

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

Probing protein structure by amino acid-specific covalent labeling and mass spectrometry

(2008) Vanessa Leah Mendoza et al.   MASS SPECTROMETRY REVIEWS