Journal
AUTOPHAGY
Volume 11, Issue 3, Pages 573-574Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1017193
Keywords
Drp1; mitochondrial dynamics; mitochondrial homeostasis; mitophagy; Parkin
Categories
Funding
- NIGMS NIH HHS [GM084015, GM089853] Funding Source: Medline
- NINDS NIH HHS [NS084154] Funding Source: Medline
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Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.
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