MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment

The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo

(2014) Kaiyan Hui et al.   CANCER LETTERS

Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins

(2014) Carolien Boeckx et al.   CANCER LETTERS

Genomic analysis of drug resistant gastric cancer cell lines by combining mRNA and microRNA expression profiling

(2014) Zhangqian Chen et al.   CANCER LETTERS

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

(2014) J L Munoz et al.   Cell Death & Disease

Oncogenic B-RafV600E abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells

(2013) Ling Zhang et al.   CANCER LETTERS

Reversing the Warburg Effect as a Treatment for Glioblastoma

(2013) Ethan Poteet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade

(2013) Bang-Bao Tao et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The Synergistic Therapeutic Effect of Temozolomide and Hyperbaric Oxygen on Glioma U251 Cell Lines is Accompanied by Alterations in Vascular Endothelial Growth Factor and Multidrug Resistance-Associated Protein-1 Levels

(2013) X-Y Lu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Gliomatosis cerebri: clinical characteristics, management, and outcomes

(2013) Selby Chen et al.   JOURNAL OF NEURO-ONCOLOGY

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

(2013) Katherine L Jameson et al.   NATURE MEDICINE

Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage

(2013) Motokazu Ito et al.   PLoS One

Oleanolic Acid Suppresses Migration and Invasion of Malignant Glioma Cells by Inactivating MAPK/ERK Signaling Pathway

(2013) Guocai Guo et al.   PLoS One

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

(2012) Jeffrey R Infante et al.   LANCET ONCOLOGY

Nix Protein Positively Regulates NF-κB Activation in Gliomas

(2012) Yuntao Lu et al.   PLoS One

Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis

(2012) Junli Zhao et al.   PLoS One

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

MEK1/2 dual-specificity protein kinases: Structure and regulation

(2011) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Candidate genes influencing sensitivity and resistance of human glioblastoma to Semustine

(2011) ZhenYu Zhao et al.   BRAIN RESEARCH BULLETIN

Chemoresistance to Temozolomide in Human Glioma Cell Line U251 is Associated with Increased Activity of O 6-methylguanine-DNA Methyltransferase and Can be Overcome by Metronomic Temozolomide Regimen

(2011) Qiang Pan et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis

(2011) Luigina Graziosi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma

(2011) Huiling Shen et al.   EXPERIMENTAL HEMATOLOGY

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

(2011) Sameer Agnihotri et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy

(2011) X. Gong et al.   NEUROLOGY

MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

(2011) Atsushi Sato et al.   STEM CELLS

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma

(2010) Xia Ding et al.   JNCI-Journal of the National Cancer Institute

Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

(2008) Xianling Guo et al.   BMC CANCER

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments

(2007) Ellen Skarpen et al.   FASEB JOURNAL