Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

(2017) Eszter Paldy et al.   Nature Communications

miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells

(2016) Jing Song et al.   CANCER SCIENCE

Transmembrane semaphorins: Multimodal signaling cues in development and cancer

(2016) Sreeharsha Gurrapu et al.   Cell Adhesion & Migration

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

(2016) Benjamin Krusche et al.   eLife

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

(2015) Jingjing Xia et al.   DEVELOPMENTAL CELL

MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C

(2015) Jiefang Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MEL-18 loss mediates estrogen receptor–α downregulation and hormone independence

(2015) Jeong-Yeon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Semaphorins and plexins as therapeutic targets

(2014) Thomas Worzfeld et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic dissection of plexin signaling in vivo

(2014) Thomas Worzfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

(2014) Roberta Azzarelli et al.   Nature Communications

Molecular pathways regulating mitotic spindle orientation in animal cells

(2013) M. S. Lu et al.   DEVELOPMENT

Sox2 promotes tamoxifen resistance in breast cancer cells

(2013) Marco Piva et al.   EMBO Molecular Medicine

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

(2013) Steven M. Frisch et al.   JOURNAL OF CELL SCIENCE

The SmgGDS Splice Variant SmgGDS-558 Is a Key Promoter of Tumor Growth and RhoA Signaling in Breast Cancer

(2013) Andrew D. Hauser et al.   MOLECULAR CANCER RESEARCH

Emerging Role of Semaphorins as Major Regulatory Signals and Potential Therapeutic Targets in Cancer

(2012) Luca Tamagnone   CANCER CELL

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

(2012) R. A. Patel et al.   CANCER RESEARCH

Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions

(2012) Prasanta K. Hota et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

(2012) Deborah A. Witherden et al.   IMMUNITY

Rho Isoform-specific Interaction with IQGAP1 Promotes Breast Cancer Cell Proliferation and Migration

(2012) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semaphorins in cancer: Biological mechanisms and therapeutic approaches

(2012) Michael Rehman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney

(2010) Nina Perälä et al.   DIFFERENTIATION

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development

(2010) Viola Maier et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

(2010) Chia-Hsin Chan et al.   NATURE CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation

(2008) Masanori Nakayama et al.   DEVELOPMENTAL CELL

ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2

(2008) S. Pancholi et al.   ENDOCRINE-RELATED CANCER