Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

(2020) Minrui Fan et al.   NATURE

S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter

(2020) Youngjin Lee et al.   Scientific Reports

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

(2019) Yan Wang et al.   CELL

Functional analysis of coiled-coil domains of MCU in mitochondrial calcium uptake

(2019) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

(2018) Maria Patron et al.   CELL DEATH AND DIFFERENTIATION

Cryo-EM structure of a mitochondrial calcium uniporter

(2018) Jiho Yoo et al.   SCIENCE

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

(2018) Chao Fan et al.   NATURE

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+

(2018) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the structure and function of EMRE in a yeast expression system

(2016) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The m -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

(2016) Tim König et al.   MOLECULAR CELL

Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

(2016) Dipayan Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

(2016) Ming-Feng Tsai et al.   eLife

Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter

(2015) Y. Lee et al.   EMBO REPORTS

The Stoichiometry and Biophysical Properties of the Kv4 Potassium Channel Complex with K+Channel-interacting Protein (KChIP) Subunits Are Variable, Depending on the Relative Expression Level

(2014) Masahiro Kitazawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Reconstitution of the mitochondrial calcium uniporter in yeast

(2014) E. Kovacs-Bogdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies

(2013) Sabine Schmitt et al.   ANALYTICAL BIOCHEMISTRY

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Mitochondrial Ca2+ homeostasis: mechanism, role, and tissue specificities

(2012) Paola Pizzo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Calcium uptake mechanisms of mitochondria

(2010) Jaime Santo-Domingo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions

(2009) Akiko Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

(2009) Elena Palma et al.   HUMAN MOLECULAR GENETICS

Differential Permeabilization Effects of Ca2+and Valinomycin on the Inner and Outer Mitochondrial Membranes as Revealed by Proteomics Analysis of Proteins Released from Mitochondria

(2009) Akiko Yamada et al.   MOLECULAR & CELLULAR PROTEOMICS