Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle

Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction

(2017) Shinji Kishimoto et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy

(2017) Qifeng Zhou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes

(2017) Biao Feng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training

(2017) Andreas B. Gevaert et al.   Oxidative Medicine and Cellular Longevity

Transforming growth factor β and its role in heart disease

(2017) Guangwang Liu et al.   Experimental and Therapeutic Medicine

MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance

(2017) João Victor Esteves et al.   Journal of Diabetes Research

Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction

(2017) Raffaele Altara et al.   Frontiers in Endocrinology

Micro–RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue FactorHighlights

(2016) Marco Witkowski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interplay of mitochondrial metabolism and microRNAs

(2016) Julian Geiger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Assessing Cardiac Metabolism

(2016) Heinrich Taegtmeyer et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation

(2016) Jozine M. ter Maaten et al.   EUROPEAN JOURNAL OF HEART FAILURE

MicroRNA-17-5p: At the Crossroads of Cancer and Aging - A Mini-Review

(2016) Hanna Dellago et al.   GERONTOLOGY

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

Biomarkers in heart failure with preserved ejection fraction

(2016) W. C. Meijers et al.   Netherlands Heart Journal

Animal models of heart failure with preserved ejection fraction

(2016) G. Conceição et al.   Netherlands Heart Journal

Understanding heart failure with preserved ejection fraction: where are we today?

(2016) L. van Heerebeek et al.   Netherlands Heart Journal

Impairment of Coronary Flow Reserve Evaluated by Phase Contrast Cine‐Magnetic Resonance Imaging in Patients With Heart Failure With Preserved Ejection Fraction

(2016) Shingo Kato et al.   Journal of the American Heart Association

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

(2016) Rohan Samson et al.   Journal of the American Heart Association

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced ObesitySignificance

(2015) Denuja Karunakaran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miR-21: a star player in cardiac hypertrophy

(2015) Burcu Duygu et al.   CARDIOVASCULAR RESEARCH

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis

(2015) Esther E. Creemers et al.   CIRCULATION RESEARCH

Innate Immunity and the Failing Heart

(2015) Douglas L. Mann   CIRCULATION RESEARCH

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction

(2015) Lee Lee Wong et al.   EUROPEAN JOURNAL OF HEART FAILURE

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure

(2015) Chris J. Watson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Evidence of microvascular dysfunction in heart failure with preserved ejection fraction

(2015) Joshua F Lee et al.   HEART

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

(2015) Xianghui Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

HypoxamiRs: regulators of cardiac hypoxia and energy metabolism

(2015) Hamid el Azzouzi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association between miR-181b and PKG 1 in myocardial hypertrophy and its clinical implications

(2015) WEI ZHONG et al.   Experimental and Therapeutic Medicine

MiR-181a regulates lipid metabolism via IDH1

(2015) Bo Chu et al.   Scientific Reports

Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction

(2015) Beshay N. Zordoky et al.   PLoS One

miR-107 orchestrates ER stress induction and lipid accumulation by post-transcriptional regulation of fatty acid synthase in hepatocytes

(2014) Himanshi Bhatia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Heart Failure With Preserved Ejection Fraction

(2014) Francesco S. Loffredo et al.   CIRCULATION RESEARCH

What Is Measured by Cardiac Fibrosis Biomarkers and Imaging?

(2014) Faiez Zannad   Circulation-Heart Failure

Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion

(2014) Mufaddal S. Soni et al.   DIABETES

Profiling of Circulating MicroRNAs Reveals Common MicroRNAs Linked to Type 2 Diabetes That Change With Insulin Sensitization

(2014) Francisco J. Ortega et al.   DIABETES CARE

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

(2014) Miguel Alejandro Lopez-Ramirez et al.   FASEB JOURNAL

Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction

(2014) Anagha Sen et al.   FEBS LETTERS

Inhibition of miR-25 improves cardiac contractility in the failing heart

(2014) Christine Wahlquist et al.   NATURE

The Association between Circulating MicroRNA Levels and Coronary Endothelial Function

(2014) R. Jay Widmer et al.   PLoS One

Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications—A Twin Study

(2014) Jette Bork-Jensen et al.   Genes

Developing Therapies for Heart Failure With Preserved Ejection Fraction

(2014) Javed Butler et al.   JACC-Heart Failure

Endothelial Microparticle–Mediated Transfer of MicroRNA-126 Promotes Vascular Endothelial Cell Repair via SPRED1 and Is Abrogated in Glucose-Damaged Endothelial Microparticles

(2013) Felix Jansen et al.   CIRCULATION

Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

(2013) Stephane Heymans et al.   CIRCULATION

MicroRNA 33 Regulates Glucose Metabolism

(2013) C. M. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

(2012) Virginija Jazbutyte et al.   AGE

miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart

(2012) Walter A. Baseler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Insulin Resistance: Metabolic Mechanisms and Consequences in the Heart

(2012) E. Dale Abel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNAs in control of cardiac hypertrophy

(2012) Paula A. Da Costa Martins et al.   CARDIOVASCULAR RESEARCH

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction

(2012) Priyatansh Gurha et al.   CIRCULATION

Developing MicroRNA Therapeutics

(2012) Eva van Rooij et al.   CIRCULATION RESEARCH

The Circulating Level of FABP3 Is an Indirect Biomarker of MicroRNA-1

(2012) Francesca Varrone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Roles of microRNA on cancer cell metabolism

(2012) Bing Chen et al.   Journal of Translational Medicine

Circulating miRNA as novel markers for diastolic dysfunction

(2012) Nandini Nair et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs

(2012) Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378

(2012) M. Carrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

(2011) Geert C. van Almen et al.   AGING CELL

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

(2011) Jagdip S. Jaswal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload–Induced Cardiac Failure

(2011) Federico Damilano et al.   CIRCULATION

Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction

(2011) Mario Kasner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

(2010) B. A. Borlaug et al.   EUROPEAN HEART JOURNAL

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism

(2010) Dimitrios Iliopoulos et al.   JOURNAL OF LIPID RESEARCH

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Plasma miR-208 as a Biomarker of Myocardial Injury

(2009) X. Ji et al.   CLINICAL CHEMISTRY

Heart Failure With Preserved Ejection Fraction Is Characterized by Dynamic Impairment of Active Relaxation and Contraction of the Left Ventricle on Exercise and Associated With Myocardial Energy Deficiency

(2009) Thanh T. Phan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes

(2009) S. Ikeda et al.   MOLECULAR AND CELLULAR BIOLOGY

Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet

(2008) Rieko Takanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA