Article
Biotechnology & Applied Microbiology
Ming Sun, Lidi Cheng, Zexian Xu, Liqiang Chen, Yanshan Liu, Yaoxiang Xu, Dongyang Zhou, Xiuxiu Zhang, Qihui Zhou, Jian Sun
Summary: This study aims to explore the potential feasibility of a novel temperature-sensitive hydrogel-based dual sustained-release system for the repair and treatment of infectious jaw defects. The results indicate that the system shows outstanding sustained-release ability, biocompatibility, and antibacterial properties. This study provides new insights for the treatment of infectious jaw defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Peter J. Cabot, Nazrul Islam, Emad L. Izake
Summary: This review discusses the biomedical application of mesoporous silica nanoparticles (MSNs) as drug carriers for cancer therapy. MSNs, with their unique properties, show great potential for improving drug solubility and delivery. The development of multimodal anticancer therapeutics and chemical modifications can further enhance the applications of MSNs. Safety issues related to these nanoparticles are also discussed.
Article
Biochemistry & Molecular Biology
Dan Shao, Qiang Gao, Yanshan Sheng, Shangji Li, Yong Kong
Summary: An intelligent drug delivery platform based on the hybrids of mesoporous silica nanoparticles, sodium hyaluronate, chitosan, and oxidized sodium carboxymethyl cellulose is developed for dual-responsive dual-drug delivery. Cell viability results demonstrate that the developed platform has significantly higher chemotherapy efficacy than single-drug encapsulated platforms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Nagaraja Sreeharsha, Manish Philip, Sivadas Swathi Krishna, Vidya Viswanad, Ram Kumar Sahu, Predeepkumar Narayanappa Shiroorkar, Afzal Haq Aasif, Santosh Fattepur, Syed Mohammed Basheeruddin Asdaq, Anroop B. Nair, Mahesh Attimarad, Katharigatta N. Venugopala
Summary: Mesoporous Silica Nanoparticles (MSNs) have revolutionized engineering designs in a wide range of materials and applications, particularly as medication delivery systems. Their unique characteristics, including tunable surface area and precise drug delivery to specific sites, make them a feasible platform for orally administered drugs.
Article
Chemistry, Physical
Eva Benova, Virginie Hornebecq, Vladimir Zelenak, Veronika Huntosova, Miroslav Almasi, Mariana Macajova, David Berge-Lefranc
Summary: The study developed a pH-responsive drug delivery system that can release drugs in the acidic medium of tumor-affected areas. Through adsorption studies, the system demonstrated drug release effectiveness under different pH conditions, and showed biocompatibility and cytotoxicity at the cellular level.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Zhenyu Zhao, Zhen Wang, Gen Li, Zhengwei Cai, Jiezhou Wu, Lei Wang, Lianfu Deng, Ming Cai, Wenguo Cui
Summary: Microfluidic hydrogel microspheres have been widely studied and used in various industries, with a focus on their applications in the medical field for controlled delivery of cells and drugs. These materials enable efficient encapsulation and control of functionalities, promoting collaboration across disciplines and advancing precision medicine and applied materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Mohsen Ghaferi, Maedeh Koohi Moftakhari Esfahani, Aun Raza, Sitah Al Harthi, Hasan Ebrahimi Shahmabadi, Seyed Ebrahim Alavi
Summary: Mesoporous silica nanoparticles (MSNPs) are innovative nanomaterials used for drug delivery systems with the potential to deliver therapeutic agents, mitigate disease progression, and improve cancer treatment. The properties, characteristics, and therapeutic applications of MSNPs have been studied, along with their potential for diagnosis and disease management. Emerging trends and future advancements of MSNPs as carriers have also been discussed.
JOURNAL OF DRUG TARGETING
(2021)
Article
Nanoscience & Nanotechnology
Bing Li, Miryam Criado-Gonzalez, Alexandre Adam, Joelle Bizeau, Christophe Melart, Alain Carvalho, Sylvie Begin, Dominique Begin, Loic Jierry, Damien Mertz
Summary: This article introduces the development of nanocomposite supramolecular hydrogels and discusses their potential applications in antitumor and tissue engineering. Through the enzyme-assisted self-assembly method, smart thermoresponsive nanocomposite supramolecular hydrogels can be designed.
ACS APPLIED NANO MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Skylar J. W. Henry, Nicholas Stephanopoulos
Summary: Recent advances in nanotechnology have led to rapid progress in various areas of biomedical research, particularly in the development of DNA nanotechnology for programmable nanostructures. These DNA nanostructures offer highly addressable platforms for biological applications due to their controllable architecture and multiple avenues for chemical modification, showing great potential for future biomedical advancements.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bianca de Melo Santana, Joana Claudio Pieretti, Rafael Nunes Gomes, Giselle Cerchiaro, Amedea Barozzi Seabra
Summary: Combining nitric oxide (NO) donor and silica nanoparticles loaded with cisplatin into a polymeric matrix can create a drug-delivery system that provides sustained and localized drug release against tumor cells.
Review
Oncology
Hong Zeng, Jia Li, Kai Hou, Yiping Wu, Hongbo Chen, Zeng Ning
Summary: Nanotechnology has great potential in the diagnosis and treatment of melanoma. Nano drug delivery systems can improve treatment effectiveness, reduce side effects, and enhance tumor targeting.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ivalina Trendafilova, Ralitsa Chimshirova, Denitsa Momekova, Hristo Petkov, Neli Koseva, Penka Petrova, Margarita Popova
Summary: Biologically active substances of natural origin are a promising alternative for treating skin diseases. The limitations of low water solubility and bioavailability in natural compounds can be overcome by developing suitable delivery systems. In this study, a silver-modified mesoporous silica nanocarrier was prepared using the template exchange procedure. The drug-loaded formulation showed high loading efficiency, and the interaction between drugs and carriers was studied. The release experiments demonstrated improved solubility, and the formulations exhibited potent antiradical, antioxidant, and antibacterial activities. The simultaneous delivery of curcumin and capsaicin showed enhanced antiproliferative effects on maligning cells. These findings suggest that the developed delivery systems have promising potential for dermal treatment.
Review
Polymer Science
Ying Bai, Bing Han, Yi Zhang, Yuan Zhang, Yang Cai, Ling Shen, Yanpeng Jia
Summary: Ischemic stroke is a leading cause of death and disability worldwide, but current treatments are largely ineffective. Hydrogel-based strategies offer a promising approach for delivering therapeutics to poststroke sites and enhancing intrinsic repair and regeneration.
Review
Pharmacology & Pharmacy
Suzana Goncalves Carvalho, Aline Martins dos Santos, Amanda Leticia Polli Silvestre, Alberto Gomes Tavares, Marlus Chorilli, Maria Palmira Daflon Gremiao
Summary: This review discusses the progress and applications of nano-in-microparticle systems in drug targeting. It also emphasizes the use of biomaterials in these systems and the challenges they face. The article proposes future perspectives for advances in clinical and field translation of multifunctional systems based on nano-in-microparticles.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Environmental Sciences
Thuany Nascimento Domingues Cunha, Daniel Graize Trindade, Matheus Martins Canesin, Luciane Effting, Alexandre Amado de Moura, Murilo Pereira Moises, Ismael Laurindo Costa Junior, Alesandro Bail
Summary: A novel eco-friendly method for treating waste pickling acid was proposed, which involved evaporation and crystallization processes to produce hydrochloric acid solution, iron(II) chloride, and magnetic iron oxide with high purity and yield.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Chemistry, Applied
Hugo H. C. de Lima, Cleiser T. P. da Silva, Vicente L. Kupfer, Jaqueline de C. Rinaldi, Erika S. Kioshima, Dalmo Mandelli, Marcos R. Guilherme, Andrelson W. Rinaldi
Summary: This study reported the preparation of an organic-inorganic hybrid hydrogel using different crystal sizes of UiO-66 MOFs, showing excellent water absorption capacity and mechanical properties. The research found that crystal size and the amount of UiO-66AA MOF significantly influenced the material properties, and HydroMOFs exhibited good drug release control performance.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Daniele M. Catori, Elizangela H. Fragal, Igor Messias, Francielle P. Garcia, Celso Nakamura, Adley F. Rubira
Summary: This study focused on evaluating the effects of cellulose nanocrystals on pectin hydrogels and the properties of hydroxyapatite obtained through different methods. The results showed that hydrogels with 5% cellulose nanocrystals exhibited better mineralization of hydroxyapatite in the biomimetic method. Overall, hydrogels obtained through biomimetic method showed slightly higher biocompatibility compared to hybrid hydrogels obtained from chemical precipitation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Pablo G. Costa, Michele K. Lima-Tenorio, Ernandes T. Tenorio-Neto, Renata A. C. Galinari, Cleiser T. P. da Silva, Hugo H. C. de Lima, Vicente L. Kupfer, Andrelson W. Rinaldi, Marcos R. Guilherme, Adley F. Rubira
Summary: Dual-responsive hydrogel composites composed of magnetite particles and alginate show excellent removal efficiency of methylene blue from aqueous environments through magnetic stimuli, with potential for reuse. Controlled by the amount of magnetite and magnetic fields, the composites exhibit remarkable adsorption capacity in specific conditions, offering a new approach for pollution control in water environments.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Engineering, Environmental
Hugo Henrique Carline de Lima, Maria Eugenia Grego Llop, Rogerio dos Santos Maniezzo, Murilo Pereira Moises, Vanderly Janeiro, Pedro Augusto Arroyo, Marcos Rogerio Guilherme, Andrelson Wellington Rinaldi
Summary: NaOH-activated hydrochars were synthesized through hydrothermal carbonization of Brazilian pine fruit shells for different residence times. These hydrochars exhibited high surface area and maximum adsorption of BPA at pH 7.0. Adsorption occurred mainly through monolayer formation with low retention time of the adsorbate, indicating endothermic spontaneous process. Desorption was more efficient with ethanol and methanol due to dipole-dipole forces, while desorption efficiency with acid, base, and salts was lower due to competitive effects.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Materials Science, Textiles
Fabricio Maesta Bezerra, Dayane Samara de Carvalho Cotre, Andre Plath, Helen Beraldo Firmino, Miliane Aparecida de Lima, Manuel Lis, Rafael Block Samulewski, Murilo Pereira Moises
Summary: The use of beta-cyclodextrin as a dyeing auxiliary agent helps reduce harmful products and increase fabric color intensity. The beta-CD:DY211 complex dyeing process results in higher coloristic intensity compared to conventional dyeing processes. Beta-cyclodextrin proves to be a suitable replacement for environmentally harmful textile aides without the need for additional steps in the dyeing process or extra equipment.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Murilo P. Moises, Cleiser Thiago P. da Silva, Cinthia A. A. Silva, Joziane G. Meneguin, Gustavo G. Fonseca, Marcos R. Guilherme, Andrelson W. Rinaldi, Emerson M. Girotto, Eduardo Radovanovic
Summary: This study synthesized a microporous sustainable Zeolite A material using agroindustry solid waste and functionalized it with silver nanoparticles. The release transport properties of silver ions were investigated, and it was found that the antimicrobial activity of the material depended on exposure time and concentration.
Article
Chemistry, Physical
Manuel E. G. Winkler, Elisangela P. da Silva, Marcos H. Kunita, Adley F. Rubira
Summary: This study presents a method for obtaining silica particles through pressured carbonation and demonstrates the influence of CO2 pressure on material properties. The simplicity and practical importance of this method, as well as its ability to synthesize various types of silica materials and composites, are highlighted.
Article
Polymer Science
Braian Lobo da Costa, Isadora Leticia Aparecida Ataide Rosa, Vitoria Hipolito Silva, Qiuyue Wu, Rafael Block Samulewski, Fabio Alexandre Pereria Scacchetti, Murilo Pereira Moises, Manuel J. Lis, Fabricio Maesta Bezerra
Summary: Metal-organic frameworks (MOFs) are nanomaterials that can be applied to textiles. This study focuses on the direct synthesis of HKUST-1 on cotton fabric. The results show that this method can successfully form nanorods on the fabric, which exhibit excellent antibacterial properties against both E. coli and S. aureus. However, the mechanical resistance of the fabric decreases significantly after the synthesis.
Article
Chemistry, Multidisciplinary
Michelly C. G. Pella, Andressa R. Simao, Marcos R. Mauricio, Douglas C. Dragunski, Rafael da Silva, Adley F. Rubira
Summary: This study evaluated the effects of different parameters on the properties of starch. The results showed that the volume and temperature of GMA had an impact on the DS and X-c, and their correlation increased the DS and Xc. Higher temperatures also favored hydrolysis. Although parameter correlations did not have a significant effect on the assessed properties, they changed the effect of individual parameters.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ana Carla R. Carneiro, Joziane G. Meneguin, Paula M. dos Santos, Marcela Z. Corazza, Maiyara Carolyne Prete, Andrelson Wellington Rinaldi, Cesar Ricardo T. Tarley
Summary: In this study, a metal-organic framework UiO-66 was synthesized and used as a support for solid-phase extraction of cadmium. Under optimized conditions, this method showed a high preconcentration factor, low detection limit, and wide linear range. UiO-66 demonstrated excellent selectivity towards cadmium and accurate analysis in different water samples.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
