Micropharmacology: An In Silico Approach for Assessing Drug Efficacy Within a Tumor Tissue

Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues

(2018) Aleksandra Karolak et al.   Journal of the Royal Society Interface

Intra-tumor heterogeneity from a cancer stem cell perspective

(2017) Pramudita R. Prasetyanti et al.   Molecular Cancer

Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

(2016) Francis W Hunter et al.   BRITISH JOURNAL OF CANCER

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

(2016) Roger M. Phillips   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Quantitating drug-target engagement in single cells in vitro and in vivo

(2016) J Matthew Dubach et al.   Nature Chemical Biology

Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors

(2016) Danika Lindsay et al.   PLoS Computational Biology

Pathology to Enhance Precision Medicine in Oncology

(2015) Mark C. Lloyd et al.   ADVANCES IN ANATOMIC PATHOLOGY

Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer

(2015) Kimberly R. Kanigel Winner et al.   CANCER RESEARCH

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes

(2015) M. Robertson-Tessi et al.   CANCER RESEARCH

Advances in measuring single-cell pharmacology in vivo

(2015) Claudio Vinegoni et al.   DRUG DISCOVERY TODAY

Targeting Tumor Hypoxia With Hypoxia-Activated Prodrugs

(2015) Jen Jen Yeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Diagnostic assessment of osteosarcoma chemoresistance based on Virtual Clinical Trials

(2015) K.A. Rejniak et al.   MEDICAL HYPOTHESES

An Interactive Tool for Animating Biology, and Its Use in Spatial and Temporal Modeling of a Cancerous Tumor and Its Microenvironment

(2015) Naamah Bloch et al.   PLoS One

Systems oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling

(2015) Gibin G. Powathil et al.   SEMINARS IN CANCER BIOLOGY

Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines

(2015) Mikhail O Durymanov et al.   Theranostics

Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles

(2015) Louis T. Curtis et al.   PLoS One

Effect of Small-Molecule Modification on Single-Cell Pharmacokinetics of PARP Inhibitors

(2014) G. M. Thurber et al.   MOLECULAR CANCER THERAPEUTICS

Understanding tissue context influences on intratumour heterogeneity

(2014) Franziska Michor et al.   NATURE CELL BIOLOGY

Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin

(2014) A. M. Laughney et al.   Science Translational Medicine

In vivo imaging of specific drug–target binding at subcellular resolution

(2014) J. M. Dubach et al.   Nature Communications

Cancer heterogeneity: implications for targeted therapeutics

(2013) R Fisher et al.   BRITISH JOURNAL OF CANCER

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Molecularly targeted cancer therapy: some lessons from the past decade

(2013) Min Huang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo

(2013) Greg M. Thurber et al.   Nature Communications

Targeted therapies in medical oncology: successes, failures and next steps

(2013) Gordon Mallarkey et al.   Therapeutic Advances in Medical Oncology

The Role of Tumor Tissue Architecture in Treatment Penetration and Efficacy: An Integrative Study

(2013) Katarzyna A. Rejniak et al.   Frontiers in Oncology

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

(2011) Mark J McKeage et al.   BMC CANCER

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer

(2011) J. D. Sun et al.   CLINICAL CANCER RESEARCH

Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid Malignancies

(2011) G. J. Weiss et al.   CLINICAL CANCER RESEARCH

Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validation

(2011) Jana L. Gevertz   Computational and Mathematical Methods in Medicine

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Current trends in mathematical modeling of tumor–microenvironment interactions: a survey of tools and applications

(2010) Katarzyna A Rejniak et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Boundary integral solutions of coupled Stokes and Darcy flows

(2008) Svetlana Tlupova et al.   JOURNAL OF COMPUTATIONAL PHYSICS