Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo

Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents

(2015) Thomas Reiner et al.   NEOPLASIA

Bioorthogonal Imaging of Aurora Kinase A in Live Cells

(2012) Katherine S. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

RGB marking with lentiviral vectors for multicolor clonal cell tracking

(2012) Kristoffer Weber et al.   Nature Protocols

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification

(2011) Ghyslain Budin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics

(2011) J. D. Orth et al.   CANCER RESEARCH

A Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors*,†

(2011) Noboru Yamamoto et al.   CANCER SCIENCE

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients WithBRCA1orBRCA2Mutations and Recurrent Ovarian Cancer

(2011) Stan B. Kaye et al.   JOURNAL OF CLINICAL ONCOLOGY

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

(2011) Laura B. Kleiman et al.   MOLECULAR CELL

A Systems Approach for Tumor Pharmacokinetics

(2011) Greg Michael Thurber et al.   PLoS One

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

(2010) S. A.L. Zander et al.   CANCER RESEARCH

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Tumor Growth Inhibition by Olaparib in BRCA2 Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts

(2010) U. Kortmann et al.   CLINICAL CANCER RESEARCH

Use of the Ki67 promoter to label cell cycle entry in living cells

(2010) Alexander C. Zambon   CYTOMETRY PART A

Optical imaging of tumor hypoxia dynamics

(2010) Gregory M. Palmer et al.   JOURNAL OF BIOMEDICAL OPTICS

124I-Iodopyridopyrimidinone for PET of Abl Kinase-Expressing Tumors In Vivo

(2010) M. Doubrovin et al.   JOURNAL OF NUCLEAR MEDICINE

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

(2010) Elizabeth J. Joslin et al.   Molecular BioSystems

The elaboration of a critical framework for understanding cancer: the cancer stem cell hypothesis

(2010) Chris Hemmings   PATHOLOGY

On the Role of Cell Signaling Models in Cancer Research

(2009) A. C. Ventura et al.   CANCER RESEARCH

Cancer Stem Cells: The Emerging Challenge of Drug Targeting

(2009) Roger Besancon et al.   CURRENT MEDICINAL CHEMISTRY

Non-genetic cell-to-cell variability and the consequences for pharmacology

(2009) Mario Niepel et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks

(2009) Axel R. Pries et al.   PLoS Computational Biology

Red/Near-infrared Boron-Dipyrromethene Dyes as Strongly Emitting Fluorophores

(2008) Ana B. Descalzo et al.   Annals of the New York Academy of Sciences

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

(2008) Keith A. Menear et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intravital imaging of metastatic behavior through a mammary imaging window

(2008) Dmitriy Kedrin et al.   NATURE METHODS