Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog

(2017) Alexandre Bossu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

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(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Antiarrhythmic effect of vernakalant in an experimental model of Long-QT-syndrome

(2016) Gerrit Frommeyer et al.   EUROPACE

Ranolazine Therapy in Cardiac Arrhythmias

(2016) BRIAN R. PULFORD et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Basis of Hypokalemia-Induced Ventricular FibrillationCLINICAL PERSPECTIVE

(2015) Arash Pezhouman et al.   CIRCULATION

Genetics of Sudden Cardiac Death

(2015) C. R. Bezzina et al.   CIRCULATION RESEARCH

Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model

(2015) Afonso S. Alves Bento et al.   HEART RHYTHM

Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

(2015) Luiz Belardinelli et al.   HEART RHYTHM

The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model

(2015) JULIANA SARAN CARNEIRO et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current

(2015) Alexander Burashnikov et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model

(2014) Samuel Sossalla et al.   Cardiovascular Therapeutics

Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity

(2014) Rodolfo Bonatti et al.   HEART RHYTHM

Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart

(2014) Sarah Fernandes et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

(2013) John C. Shryock et al.   CARDIOVASCULAR RESEARCH

Combined Na + /Ca 2+ Exchanger and L-Type Calcium Channel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function

(2013) Vincent J.A. Bourgonje et al.   Circulation-Arrhythmia and Electrophysiology

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

(2013) Serge Sicouri et al.   HEART RHYTHM

Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts

(2013) Arash Pezhouman et al.   HEART RHYTHM

Decision Making in Advanced Heart Failure

(2012) Larry A. Allen et al.   CIRCULATION

Safety of Flecainide

(2012) Juan Tamargo et al.   DRUG SAFETY

Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2

(2012) Ashish Parikh et al.   HEART RHYTHM

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

(2011) L Nalos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug-Induced Torsade de Pointes Arrhythmias in the Chronic AV Block Dog Are Perpetuated by Focal Activity

(2011) Mohamed Boulaksil et al.   Circulation-Arrhythmia and Electrophysiology

Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization

(2011) Peter Milberg et al.   HEART RHYTHM

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action

(2010) A Oros et al.   BRITISH JOURNAL OF PHARMACOLOGY

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(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Late Na+Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model

(2010) Gudrun Antoons et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

(2008) Peter Milberg et al.   HEART RHYTHM

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

The canine model with chronic, complete atrio-ventricular block

(2008) Avram Oros et al.   PHARMACOLOGY & THERAPEUTICS

The cardiac persistent sodium current: an appealing therapeutic target?

(2007) D A Saint   BRITISH JOURNAL OF PHARMACOLOGY