Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening

(2017) Maxime Louet et al.   Scientific Reports

Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies

(2016) Paola Imbrici et al.   FASEB JOURNAL

Progressive Cl − channel defects reveal disrupted skeletal muscle maturation in R6/2 Huntington’s mice

(2016) Daniel R. Miranda et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kidney CLC-K chloride channels inhibitors

(2016) Antonella Liantonio et al.   JOURNAL OF HYPERTENSION

Structure of a CLC chloride ion channel by cryo-electron microscopy

(2016) Eunyong Park et al.   NATURE

Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery

(2016) Paola Imbrici et al.   Frontiers in Pharmacology

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita

(2015) Mauro Lo Monaco et al.   CLINICAL NEUROPHYSIOLOGY

Targeting ion channels in cystic fibrosis

(2015) Marcus A. Mall et al.   Journal of Cystic Fibrosis

ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation

(2015) P. Imbrici et al.   JOURNAL OF PHYSIOLOGY-LONDON

Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita

(2015) Simona Portaro et al.   NEUROMOLECULAR MEDICINE

ClC-1 chloride channels: state-of-the-art research and future challenges

(2015) Paola Imbrici et al.   Frontiers in Cellular Neuroscience

Targeting kidney CLC-K channels: Pharmacological profile in a human cell line versus Xenopus oocytes

(2014) Paola Imbrici et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs

(2014) Jean-François Desaphy et al.   EXPERIMENTAL NEUROLOGY

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

(2013) Jean-François Desaphy et al.   EXPERIMENTAL NEUROLOGY

Nondystrophic myotonia: Challenges and future directions

(2013) Jaya R. Trivedi et al.   EXPERIMENTAL NEUROLOGY

A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene

(2013) Raffaella Brugnoni et al.   JOURNAL OF HUMAN GENETICS

Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice

(2013) Sabata Pierno et al.   PLoS One

CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

(2013) Daniela Skálová et al.   PLoS One

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction

(2013) C. W. Waters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of common gating of a ClC chloride channel

(2013) Brett Bennetts et al.   Nature Communications

Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists

(2012) Francesco Sirci et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

Screening for mutations in Spanish families with myotonia. Functional analysis of novel mutations in CLCN1 gene

(2011) María J. Mazón et al.   NEUROMUSCULAR DISORDERS

Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels

(2010) G Zifarelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3

(2010) Chihab Klose et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

(2010) Liang Feng et al.   SCIENCE

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs

(2009) Hongzhen Hu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY