Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Platinum-based drugs: past, present and future

(2016) Shahana Dilruba et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Nucleotide excision repair is impaired by binding of transcription factors to DNA

(2016) Radhakrishnan Sabarinathan et al.   NATURE

Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes

(2016) Dilmi Perera et al.   NATURE

The genomic landscape of cutaneous melanoma

(2016) Tongwu Zhang et al.   Pigment Cell & Melanoma Research

Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma

(2016) Hyun Gyu Lee et al.   Oncotarget

Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair

(2016) Timothy Budden et al.   Oncotarget

Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance

(2015) Ewan M. McNeil et al.   DNA REPAIR

Pro-Survival Role of MITF in Melanoma

(2015) Mariusz L. Hartman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epigenetic synergy between decitabine and platinum derivatives

(2015) Taichun Qin et al.   Clinical Epigenetics

Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?

(2014) Nikola A. Bowden   CANCER LETTERS

Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics

(2014) S. V. Hato et al.   CLINICAL CANCER RESEARCH

Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer

(2014) You-Wei Zhang et al.   Epigenetics

A Majority of Human Melanoma Cell Lines Exhibits an S Phase-Specific Defect in Excision of UV-Induced DNA Photoproducts

(2014) François Bélanger et al.   PLoS One

Decitabine Rescues Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma

(2014) Chi T. Viet et al.   PLoS One

Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer

(2014) T. N. Pathiraja et al.   Science Translational Medicine

High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq

(2014) Yangxing Zhao et al.   Clinical Epigenetics

Loss of ARF Sensitizes Transgenic BRAFV600E Mice to UV-Induced Melanoma via Suppression of XPC

(2013) C. Luo et al.   CANCER RESEARCH

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

(2013) Alo Ray et al.   DNA REPAIR

Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma

(2013) C C Jiang et al.   ONCOGENE

Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma

(2013) Nikola A. Bowden et al.   PLoS One

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs

(2012) Jessica Charlet et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetic Resensitization to Platinum in Ovarian Cancer

(2012) D. Matei et al.   CANCER RESEARCH

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance

(2012) D. Wroblewski et al.   CARCINOGENESIS

CpG island shore methylation regulates caveolin-1 expression in breast cancer

(2012) X Rao et al.   ONCOGENE

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Nucleotide Excision Repair Factor XPC Enhances DNA Damage-Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2

(2011) Q.-E. Wang et al.   CANCER RESEARCH

Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells

(2011) Qian-Ying Liu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo

(2011) Oscar Alcazar et al.   INTERNATIONAL JOURNAL OF CANCER

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

(2011) W. Joost Lesterhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

(2011) T Strub et al.   ONCOGENE

Identification of DNA repair gene Ercc1 as a novel target in melanoma

(2011) Liang Song et al.   Pigment Cell & Melanoma Research

Nucleotide Excision Repair Gene Expression after Cisplatin Treatment in Melanoma

(2010) N. A. Bowden et al.   CANCER RESEARCH

Patterns of Expression of DNA Repair Genes and Relapse From Melanoma

(2010) R. Jewell et al.   CLINICAL CANCER RESEARCH

Downregulation of XPF–ERCC1 enhances cisplatin efficacy in cancer cells☆

(2010) Sanjeevani Arora et al.   DNA REPAIR

Aberrant DNA methylation in malignant melanoma

(2010) Carolina Schinke et al.   MELANOMA RESEARCH

DNA Repair in Mammalian Cells

(2009) T. Nouspikel   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications

(2009) Ruth Halaban et al.   PLoS One

DDB2 decides cell fate following DNA damage

(2009) T. Stoyanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel

(2008) Lifeng Wang et al.   BMC CANCER

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation

(2008) H J Jun et al.   BRITISH JOURNAL OF CANCER

Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer

(2008) J Matsubara et al.   BRITISH JOURNAL OF CANCER

Small Molecular Weight Variants of p53 Are Expressed in Human Melanoma Cells and Are Induced by the DNA-Damaging Agent Cisplatin

(2008) K. A. Avery-Kiejda et al.   CLINICAL CANCER RESEARCH

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer

(2007) Min Kyoung Kim et al.   EUROPEAN JOURNAL OF CANCER