Transcription Factor-Based Biosensors in High-Throughput Screening: Advances and Applications

Biosensor-Based Evolution and Elucidation of a Biosynthetic Pathway in Escherichia coli

(2017) Yongfei Liu et al.   ACS Synthetic Biology

Biosensor-Enabled Directed Evolution to Improve Muconic Acid Production in Saccharomyces cerevisiae

(2017) John M. Leavitt et al.   Biotechnology Journal

Coordinated transcription factor and promoter engineering to establish strong expression elements inSaccharomyces cerevisiae

(2016) John M. Leavitt et al.   Biotechnology Journal

Biosensor-based engineering of biosynthetic pathways

(2016) Jameson K Rogers et al.   CURRENT OPINION IN BIOTECHNOLOGY

Evolving the l-lysine high-producing strain of Escherichia coli using a newly developed high-throughput screening method

(2016) Yan Wang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

SensiPath: computer-aided design of sensing-enabling metabolic pathways

(2016) Baudoin Delépine et al.   NUCLEIC ACIDS RESEARCH

The EcoCyc database: reflecting new knowledge aboutEscherichia coliK-12

(2016) Ingrid M. Keseler et al.   NUCLEIC ACIDS RESEARCH

Genetic circuit design automation

(2016) A. A. K. Nielsen et al.   SCIENCE

Coordinated transcription factor and promoter engineering to establish strong expression elements inSaccharomyces cerevisiae

(2016) John M. Leavitt et al.   Biotechnology Journal

Transcription factor-based biosensors in biotechnology: current state and future prospects

(2015) Regina Mahr et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks

(2015) Vinicius A. C. Abreu et al.   BMC GENOMICS

Directed evolution 2.0: improving and deciphering enzyme properties

(2015) Feng Cheng et al.   CHEMICAL COMMUNICATIONS

Development of biosensors and their application in metabolic engineering

(2015) Jie Zhang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Design of an ectoine-responsive AraC mutant and its application in metabolic engineering of ectoine biosynthesis

(2015) Wei Chen et al.   METABOLIC ENGINEERING

RegulonDB version 9.0: high-level integration of gene regulation, coexpression, motif clustering and beyond

(2015) Socorro Gama-Castro et al.   NUCLEIC ACIDS RESEARCH

Programmed Evolution for Optimization of Orthogonal Metabolic Output in Bacteria

(2015) Todd T. Eckdahl et al.   PLoS One

A Competitive Flow Cytometry Screening System for Directed Evolution of Therapeutic Enzyme

(2015) Feng Cheng et al.   ACS Synthetic Biology

Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening

(2015) Sijin Li et al.   ACS Synthetic Biology

Transcription factor-based biosensors enlightened by the analyte

(2015) Raul Fernandez-López et al.   Frontiers in Microbiology

Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas

(2014) Feng Cheng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced production of fatty alcohols by engineering the TAGs synthesis pathway inSaccharomyces cerevisiae

(2014) Xiaoling Tang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Looking for the pick of the bunch: high-throughput screening of producing microorganisms with biosensors

(2014) Marcus Schallmey et al.   CURRENT OPINION IN BIOTECHNOLOGY

The differential response of thePbenpromoter ofPseudomonas putida mt-2 to BenR and XylS prevents metabolic conflicts inm-xylene biodegradation

(2014) Danilo Pérez-Pantoja et al.   ENVIRONMENTAL MICROBIOLOGY

Negative selection and stringency modulation in phage-assisted continuous evolution

(2014) Jacob C Carlson et al.   Nature Chemical Biology

Principles of genetic circuit design

(2014) Jennifer A N Brophy et al.   NATURE METHODS

Evolution-guided optimization of biosynthetic pathways

(2014) Srivatsan Raman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coli ribose binding protein based bioreporters revisited

(2014) Artur Reimer et al.   Scientific Reports

RegPrecise 3.0 – A resource for genome-scale exploration of transcriptional regulation in bacteria

(2013) Pavel S Novichkov et al.   BMC GENOMICS

Protein Engineering of the Antitumor Enzyme PpADI for Improved Thermal Resistance

(2013) Leilei Zhu et al.   CHEMBIOCHEM

Screening for Enhanced Triacetic Acid Lactone Production by Recombinant Escherichia coli Expressing a Designed Triacetic Acid Lactone Reporter

(2013) Shuang-Yan Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic engineering for enhanced fatty acids synthesis in Saccharomyces cerevisiae

(2013) Xiaoling Tang et al.   METABOLIC ENGINEERING

Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli

(2013) Solvej Siedler et al.   METABOLIC ENGINEERING

Programming adaptive control to evolve increased metabolite production

(2013) Howard H. Chou et al.   Nature Communications

Synthetic Gene Circuit-Mediated Monitoring of Endogenous Metabolites: Identification of GAL11 as a Novel Multicopy Enhancer of S-Adenosylmethionine Level in Yeast

(2013) Taichi Umeyama et al.   ACS Synthetic Biology

SoxR as a Single-Cell Biosensor for NADPH-Consuming Enzymes in Escherichia coli

(2013) Solvej Siedler et al.   ACS Synthetic Biology

Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways

(2013) Georg Schendzielorz et al.   ACS Synthetic Biology

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids

(2012) Nurije Mustafi et al.   METABOLIC ENGINEERING

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Transcription Factor-Based Screens and Synthetic Selections for Microbial Small-Molecule Biosynthesis

(2012) Jeffrey A. Dietrich et al.   ACS Synthetic Biology

A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level

(2012) Stephan Binder et al.   GENOME BIOLOGY

Engineering Biological Systems with Synthetic RNA Molecules

(2011) Joe C. Liang et al.   MOLECULAR CELL

Control of bacterial virulence by AraC-like regulators that respond to chemical signals

(2011) Ji Yang et al.   TRENDS IN MICROBIOLOGY

Product-Induced Gene Expression, a Product-Responsive Reporter Assay Used To Screen Metagenomic Libraries for Enzyme-Encoding Genes

(2010) T. Uchiyama et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Protein Engineering - An Option for Enzymatic Biofuel Cell Design

(2010) Güray Güven et al.   ELECTROANALYSIS

Where microbiology meets microengineering: design and applications of reporter bacteria

(2010) Jan Roelof van der Meer et al.   NATURE REVIEWS MICROBIOLOGY

EcoCyc: a comprehensive database of Escherichia coli biology

(2010) I. M. Keseler et al.   NUCLEIC ACIDS RESEARCH

Ultrahigh-Throughput FACS-Based Screening for Directed Enzyme Evolution

(2009) Guangyu Yang et al.   CHEMBIOCHEM

Genetically encoded biosensors based on engineered fluorescent proteins

(2009) Wolf B. Frommer et al.   CHEMICAL SOCIETY REVIEWS

Responses of Pseudomonas to small toxic molecules by a mosaic of domains

(2009) Juan L Ramos et al.   CURRENT OPINION IN MICROBIOLOGY

Computer-aided design of functional protein interactions

(2009) Daniel J Mandell et al.   Nature Chemical Biology

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes

(2009) Pavel S. Novichkov et al.   NUCLEIC ACIDS RESEARCH

Solution structure of the DNA binding domain of AraC protein

(2009) Michael E. Rodgers et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

AraC Regulatory Protein Mutants with Altered Effector Specificity

(2008) Shuang-Yan Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

(2008) S. E. Maddocks et al.   MICROBIOLOGY-SGM

Substrate-induced gene expression (SIGEX) screening of metagenome libraries

(2008) Taku Uchiyama et al.   Nature Protocols

PRODORIC (release 2009): a database and tool platform for the analysis of gene regulation in prokaryotes

(2008) A. Grote et al.   NUCLEIC ACIDS RESEARCH