Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG

Matrix stiffness controls cardiac fibroblast activation through regulating YAP via AT1 R

(2020) Lele Niu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart

(2020) Xinming Wang et al.   Acta Biomaterialia

Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart

(2019) Matthew Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction

(2019) Zhouguang Wang et al.   Acta Biomaterialia

Matrix stiffness regulates microvesicle-induced fibroblast activation

(2019) Samantha C. Schwager et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes

(2019) Subhadip Senapati et al.   ANALYTICAL CHEMISTRY

Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues

(2019) Gabriela Leão Santos et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction

(2018) William M. Torres et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Early Regenerative Capacity in the Porcine Heart

(2018) Lei Ye et al.   CIRCULATION

Biomarkers for the identification of cardiac fibroblast and myofibroblast cells

(2018) Emiri Tarbit et al.   HEART FAILURE REVIEWS

The local microenvironment limits the regenerative potential of the mouse neonatal heart

(2018) Mario Notari et al.   Science Advances

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

(2018) Ian Pitha et al.   Translational Vision Science & Technology

Rho-kinase inhibition is beneficial in fibrosis

(2017) Jan Görtzen et al.   HEPATOLOGY

Paxillin: a crossroad in pathological cell migration

(2017) Ana María López-Colomé et al.   Journal of Hematology & Oncology

Impact of matrix stiffness on fibroblast function

(2017) Hichem El-Mohri et al.   Materials Science & Engineering C-Materials for Biological Applications

Mechanical regulation of cardiac fibroblast profibrotic phenotypes

(2017) Kate M. Herum et al.   MOLECULAR BIOLOGY OF THE CELL

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

(2016) Virpi Talman et al.   CELL AND TISSUE RESEARCH

Defining the Cardiac Fibroblast

(2016) Malina J. Ivey et al.   CIRCULATION JOURNAL

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

(2016) Jessica N. Blom et al.   Jove-Journal of Visualized Experiments

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

(2016) W. C. W. Chen et al.   Science Advances

Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations

(2015) Jeremy R. McGarvey et al.   ANNALS OF THORACIC SURGERY

Statins, Rho GTPases and KLF2: new mechanistic insight into liver fibrosis and portal hypertension

(2015) Jonel Trebicka et al.   GUT

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

(2015) Ke Wei et al.   NATURE

Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

(2015) Yfat Yahalom-Ronen et al.   eLife

Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

(2014) Pei-Suen Tsou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload–Induced Heart Failure

(2014) Zoltán Szabó et al.   HYPERTENSION

Platelet-derived growth factor blockade on cardiac remodeling following infarction

(2014) Chang Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro

(2013) C. Williams et al.   Acta Biomaterialia

Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration

(2013) Fabio R. Formiga et al.   JOURNAL OF CONTROLLED RELEASE

Paxillin controls directional cell motility in response to physical cues

(2013) Julia E. Sero et al.   Cell Adhesion & Migration

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Substrate stiffness influences TGF-β1-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling

(2012) YANLING SHI et al.   Molecular Medicine Reports

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells

(2010) Koji Nobe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho Kinase Regulation of Fibroblast Migratory Mechanics in Fibrillar Collagen Matrices

(2010) Chengxin Zhou et al.   Cellular and Molecular Bioengineering

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading

(2010) Pei-Wen Chen et al.   Cell Adhesion & Migration

Up-Regulation of Two Actin-Associated Proteins Prompts Pulmonary Artery Smooth Muscle Cell Migration under Hypoxia

(2009) Ruifeng Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin

(2009) Toshiyuki Tanaka et al.   CANCER SCIENCE

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

(2009) S. B. Haudek et al.   CARDIOVASCULAR RESEARCH

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Mechanobiology of cardiomyocyte development

(2009) Jeffrey G. Jacot et al.   JOURNAL OF BIOMECHANICS

FAK, PIP5KI  and gelsolin cooperatively mediate force-induced expression of  -smooth muscle actin

(2009) M. W. C. Chan et al.   JOURNAL OF CELL SCIENCE

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Comparative Functional Analysis of the Caenorhabditis elegans and Drosophila melanogaster Proteomes

(2009) Sabine P Schrimpf et al.   PLOS BIOLOGY

Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction

(2008) Stefan Frantz et al.   BASIC RESEARCH IN CARDIOLOGY