Article
Biochemistry & Molecular Biology
Iuliia Pilipenko, Olga Korovkina, Nina Gubina, Viktoria Ekimova, Anastasia Ishutinova, Evgenia Korzhikova-Vlakh, Tatiana Tennikova, Viktor Korzhikov-Vlakh
Summary: Messenger RNA (mRNA) holds promise as a therapeutic agent for disease treatment, and poly(lysine-co-isoleucine) polypeptides have been investigated as efficient carriers for mRNA delivery. The obtained copolymers showed high encapsulation efficacy, protection from degradation, and lower toxicity compared to other vectors, making them promising candidates for mRNA delivery applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Pawel Groch, Marzena Bialek
Summary: The influence of the composition of ethylene/alpha,omega-alkenol copolymers on comonomer distribution and dynamic rheological properties was investigated. The results showed that the copolymers contained different lengths of methylene sequences, and the viscoelastic behavior of the copolymers depended on the content of alpha,omega-alkenol. FTIR investigation confirmed the presence of inter- and intramolecular hydrogen bonds in the ethylene copolymers. The incorporation of alpha,omega-alkenols into the polymer chain led to a decrease in the packing length of the copolymers.
Article
Sport Sciences
Micah C. Garcia, Bryan C. Heiderscheit, Amanda M. Murray, Grant E. Norte, Emily Kraus, David M. Bazett-Jones
Summary: This study examined the temporal-spatial parameters of adolescent runners at different stages of physical maturation, and found that sex and maturation have an influence on cadence and step length. It is recommended to consider the runner's sex, stage of physical maturation, and leg length when assessing and prescribing cadence and step length.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Polymer Science
Svetlana Ch Gagieva, Vladislav A. Tuskaev, Kasim F. Magomedov, Margarita A. Moskalenko, Alexander A. Pavlov, Marina Yu Meshchankina, Maxim A. Shcherbina, Boris M. Bulychev
Summary: The study showed that catalysts immobilized on MgCl2 exhibit higher activity compared to homogeneous precatalysts. Pre-catalysts prepared through specific methods can successfully produce ultra-high molecular weight polyethylene, showing good performance even at high temperatures. Supported precatalysts effectively catalyze ethylene-higher olefin copolymerization in the presence of MAO.
Article
Chemistry, Multidisciplinary
Junyang Deng, Yifu Guo, Weiwei Li, Zhenhua Xie, Yubin Ke, Rene A. J. Janssen, Mengmeng Li
Summary: As a versatile class of semiconductors, diketopyrrolopyrrole (DPP)-based conjugated polymers are well suited for applications of next-generation plastic electronics because of their excellent and tunable optoelectronic properties via a rational design of chemical structures. However, it remains a challenge to unravel and eventually influence the correlation between their solution-state aggregation and solid-state microstructure.
Article
Chemistry, Physical
Min Cai, Xuelian He, Zhen Liu, Boping Liu
Summary: Through molecular dynamics simulations, we investigated the molecular mechanism of short-chain branching (SCB) in the nucleation process, crystallization process, and chain entanglement of trimodal polyethylene (PE). Our results reveal that an increase in SCB concentration significantly hinders the flipping and movement of PE chains, leading to prolonged nucleation and crystallization time and reduced crystallinity. On the other hand, an increase in SCB length only slightly slows down chain diffusion rate and slightly increases crystallization time. Additionally, we find that the distribution of SCBs on high molecular weight chains in trimodal PE promotes chain entanglement and prevents micro phase separation, unlike when SCBs are distributed on medium molecular weight chains.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Nanoscience & Nanotechnology
Liam R. MacFarlane, Huda Shaikh, J. Diego Garcia-Hernandez, Marcus Vespa, Tomoya Fukui, Ian Manners
Summary: pi-Conjugated polymers exhibit diverse electronic and optical properties. This review discusses the preparation of self-assembled nanoparticles from these polymers and their applications in optoelectronics, biomedical imaging and therapy, photocatalysis, and sensing. The development of pi-conjugated polymers has opened up new possibilities for functional organic materials similar to inorganic semiconductors, with nanoparticles based on these polymers showing promise in various emerging applications.
NATURE REVIEWS MATERIALS
(2021)
Review
Chemistry, Physical
Youngkwon Kim, Hyeonjung Park, Jin Su Park, Jin-Woo Lee, Felix Sunjoo Kim, Hyeong Jun Kim, Bumjoon J. Kim
Summary: This review highlights recent advances in molecular design of conjugated polymers, focusing on the impact of tuning regioregularity (RR) on their properties and performances in organic electronics. We emphasize the importance of RR control in CPs design and its applications in efficient organic electronics.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biochemistry & Molecular Biology
Yamin Abdouni, Gijs M. ter Huume, Gokhan Yilmaz, Alessandra Monaco, Carlos Redondo-Gomez, E. W. Meijer, Anja R. A. Palmans, C. Remzi Becer
Summary: Amphiphilic glycopolymers were synthesized via Cu-RDRP, forming multi-chain or single-chain polymeric nanoparticles depending on the chemical composition. Their folding is driven by amphiphilicity and the supramolecular formation of BTAs. The addition of different components affects the binding affinity of the nanoparticles, with the addition of BTAs leading to unpredictability in the relationship between particle nature and binding ability.
Article
Polymer Science
Farnaz Jafari, Gokhan Yilmaz, C. Remzi Becer
Summary: Glycopolymers with sugar groups on their pendant chains have excellent hydrophilicity, biodegradability, and biocompatibility, making them promising for biological and biomedical applications. Stimuli-responsive polymers, such as thermo-responsive, pH-responsive, and light-responsive materials, have also gained attention for their ability to respond to changes in the surrounding environment.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Anna K. Blakney, Paul F. McKay, Clement R. Bouton, Kai Hu, Karnyart Samnuan, Robin J. Shattock
Summary: In this study, it was found that PIV-5 V and MERS-CoV ORF4a proteins significantly enhanced protein expression of saRNA in vitro, while ruxolitinib showed similar effects in vivo. These experiments demonstrate the potential of directly encoding IIPs into saRNA vectors to mitigate dose dependency and enhance immunogenicity.
Article
Chemistry, Multidisciplinary
Anna K. Blakney, Polina Deletic, Paul F. McKay, Clement R. Bouton, Marianne Ashford, Robin J. Shattock, Alan Sabirsh
Summary: This study explores the effects of different lipid formulations on mRNA uptake and expression in human skin explants, finding that adipocytes efficiently express mRNA and contribute significantly to total RNA-encoded protein expression. Other cell types also increase mRNA expression over 72 hours, regardless of lipid formulation. The overall charge of particles, rather than the lipid classification, predicts the pattern of mRNA uptake and expression among resident cell types.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Medicine, General & Internal
Anna K. Blakney, Paul F. McKay
Review
Immunology
Anna K. Blakney, Shell Ip, Andrew J. Geall
Summary: This review explores the four major pillars required for design and development of an saRNA vaccine, discussing antigen design, vector design, non-viral delivery systems, and manufacturing. It reports on major innovations, preclinical and clinical data from the last five years, and provides insights into future prospects.
Article
Medicine, Research & Experimental
Han Han Ly, Simon Daniel, Shekinah K. V. Soriano, Zoltan Kis, Anna K. Blakney
Summary: Lipid nanoparticles (LNPs) are crucial for RNA delivery, but there are challenges in optimizing the parameters and compositions for larger RNA payloads. This study used two design of experiments iterations to optimize saRNA formulations and found that PEG plays a critical role in preserving CQAs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Cameron Webb, Shell Ip, Nuthan Bathula, Petya Popova, Shekinah K. Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C. Ramsay, Yvonne Perrie, Anna K. Blakney
Summary: The COVID-19 pandemic has led to the rapid development of mRNA vaccines, thanks to the modular nature of mRNA sequences and lipid nanoparticle (LNP) technology. The success of mRNA vaccines opens up possibilities for future RNA medicines, but there is already a strain on manufacturing capacity, which will be exacerbated by the development of other mRNA drugs in the near future.
MOLECULAR PHARMACEUTICS
(2022)
Editorial Material
Medicine, Research & Experimental
Anna K. Blakney
MOLECULAR PHARMACEUTICS
(2022)
Article
Cell Biology
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock
Summary: This study found that viral transmembrane domains can efficiently load antigens onto the surface of extracellular vesicles (EVs), and that EV-bound antigens enhance both humoral and cell-mediated antigen-specific responses.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Editorial Material
Multidisciplinary Sciences
Anna K. K. Blakney
Summary: As messenger RNA therapeutics expand beyond vaccines, the issue of RNA instability needs to be resolved. A novel algorithm has been developed to optimize mRNA sequences for both stability and amino acid encoding.
Meeting Abstract
Biotechnology & Applied Microbiology
Anitha Thomas, Sams Sadat, Srinavas Abbina, Nikita Jain, Pierrot Harvie, Suraj Abraham, Sijo Chemmannur, Ariel Zhang, Helena Son, Rehan Higgins, Cece Nazaripour, Newsha Arezi, Sitalakshmi Thampatty, Alex Shapiro, Derrick Stebbing, Emily Soon, Karen Markwick, Aleksei Angell, Leanna Yee, Anna Blakney, Robin Shattock, Andy Geall, Lloyd Jeffs
Meeting Abstract
Biotechnology & Applied Microbiology
Anitha Thomas, Cece Nazaripour, Rehan Higgins, Suraj Abraham, Srinavas Abbina, Helena Son, Sams Sadat, Leanna Yee, Eve Boyer, Shannon Tsai, Malathi Anantha, Sijo Chemmannur, Anna Blakney, Robin Shattock, Andy Geall, Lloyd Jeffs
