Bone Marrow Micro-Environment in Normal and Deranged Hematopoiesis: Opportunities for Regenerative Medicine and Therapies

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

(2017) Aurélie Hérault et al.   NATURE

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis

(2017) Matthew Decker et al.   NATURE CELL BIOLOGY

Cell–matrix signals specify bone endothelial cells during developmental osteogenesis

(2017) Urs H. Langen et al.   NATURE CELL BIOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow

(2017) Alon Greenbaum et al.   Science Translational Medicine

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging

(2017) Sarah E. Latchney et al.   SEMINARS IN HEMATOLOGY

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

(2017) Antonio Pierini et al.   Nature Communications

Hematopoietic Stem Cell Niche in Health and Disease

(2016) Jonathan Hoggatt et al.   Annual Review of Pathology-Mechanisms of Disease

Adult hematopoietic stem cells lacking Hif-1  self-renew normally

(2016) M. Vukovic et al.   BLOOD

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

(2016) K. B. Schoedel et al.   BLOOD

The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling

(2016) Wanda Kwan et al.   Cell Stem Cell

CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages

(2016) Jin Hur et al.   Cell Stem Cell

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

(2016) Ana Cordeiro Gomes et al.   IMMUNITY

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

(2016) Catherine M. Sawai et al.   IMMUNITY

Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow

(2016) Hyeongil Kwak et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

(2016) Duozhuang Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

(2016) S Chen et al.   LEUKEMIA

Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients

(2016) E K von der Heide et al.   LEUKEMIA

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

(2016) Edwin D. Hawkins et al.   NATURE

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

(2016) James Y. Chen et al.   NATURE

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

(2016) Y. Taya et al.   SCIENCE

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

(2016) Michael G. Poulos et al.   Nature Communications

Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy

(2015) M. V. Dhodapkar et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche

(2015) Yubin Luo et al.   Cell Metabolism

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

(2015) N. A. Zambetti et al.   HAEMATOLOGICA

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

(2015) Christopher N. Inra et al.   NATURE

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

(2015) Shiri Gur-Cohen et al.   NATURE MEDICINE

Fetal liver hematopoietic stem cell niches associate with portal vessels

(2015) J. A. Khan et al.   SCIENCE

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration

(2015) J C Huang et al.   Blood Cancer Journal

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

(2015) N. A. Zambetti et al.   HAEMATOLOGICA

ROBO4-Mediated Vascular Integrity Regulates the Directionality of Hematopoietic Stem Cell Trafficking

(2015) Stephanie Smith-Berdan et al.   Stem Cell Reports

Idiopathic aplastic anemia: Diagnosis and classification

(2014) Osnat Jarchowsky Dolberg et al.   AUTOIMMUNITY REVIEWS

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

(2014) M. Krevvata et al.   BLOOD

Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner

(2014) Lin Wang et al.   Cell Stem Cell

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

(2014) Amit Grover et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

(2014) Rebekka K Schneider et al.   Journal of Hematology & Oncology

Serial exome analysis of disease progression in premalignant gammopathies

(2014) S Zhao et al.   LEUKEMIA

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

(2014) Lorena Arranz et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

(2014) Terrence N. Wong et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

(2014) Daisuke Nakada et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

(2013) A. V. Guitart et al.   BLOOD

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

(2013) Noboru Asada et al.   Cell Stem Cell

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreERT2lines

(2013) Min-Yu Sun et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

(2012) G. L. Uy et al.   BLOOD

Myelopoiesis is regulated by osteocytes through Gs -dependent signaling

(2012) K. Fulzele et al.   BLOOD

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

(2012) Bin Zhang et al.   CANCER CELL

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

(2012) Heather A. Himburg et al.   Cell Reports

Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts

(2011) O. Blau et al.   BLOOD

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia

(2011) Thomas Schmidt et al.   CANCER CELL

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib

(2011) E Weisberg et al.   LEUKEMIA

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Donor Cell Leukemia: A Review

(2010) Daniel H. Wiseman   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial

(2010) Gareth J Morgan et al.   LANCET

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators

(2008) Kimberley Hatfield et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE