Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97-p47 Complex

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy

(2014) H. O. Yeung et al.   Open Biology

Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

(2013) Tsui-Fen Chou et al.   ChemMedChem

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships

(2012) Paolo Polucci et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission

(2012) C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of p97 AAA ATPase inhibitors

(2011) Tsui-Fen Chou et al.   Autophagy

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System

(2011) Tsui-Fen Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

The complexities of p97 function in health and disease

(2010) Eli Chapman et al.   Molecular BioSystems

A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation

(2009) Anne Beskow et al.   JOURNAL OF MOLECULAR BIOLOGY

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE