Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems

(2018) Tarek Magdy et al.   Annual Review of Pharmacology and Toxicology

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

(2018) Sini M. Kinnunen et al.   Scientific Reports

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

(2017) Mika J. Välimäki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

(2017) Mónica P. A. Ferreira et al.   Small

Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles

(2016) Chatchai Kesornpun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

(2016) Yen-Sin Ang et al.   CELL

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

(2016) Luis Luna-Zurita et al.   CELL

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase

(2016) Anne Kerbrat et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5

(2015) Sini Kinnunen et al.   PLoS One

An environmentally benign synthesis of isoxazolines and isoxazoles mediated by potassium chloride in water

(2014) Liuquan Han et al.   TETRAHEDRON LETTERS

Stem cells: balancing resistance and sensitivity to DNA damage

(2014) Julia C. Liu et al.   TRENDS IN CELL BIOLOGY

Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells

(2014) Gabor Földes et al.   Stem Cell Reports

GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy

(2013) Ruo-Gu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

(2013) Julia C. Liu et al.   Cell Stem Cell

An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle

(2013) Vikas Gupta et al.   CURRENT BIOLOGY

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

(2012) Raluca Dumitru et al.   MOLECULAR CELL

Development of High Content Imaging Methods for Cell Death Detection in Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Maxime Mioulane et al.   Journal of Cardiovascular Translational Research

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

(2011) Virpi Talman et al.   PLoS One

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

(2010) Richard N. Butler et al.   CHEMICAL REVIEWS

GATA-4 Is an Angiogenic Survival Factor of the Infarcted Heart

(2010) Jaana Rysä et al.   Circulation-Heart Failure

‘On-water’ synthesis of chromeno-isoxazoles mediated by [hydroxy(tosyloxy)iodo]benzene (HTIB)

(2010) Mustafa J. Raihan et al.   GREEN CHEMISTRY

LowModeMD—Implicit Low-Mode Velocity Filtering Applied to Conformational Search of Macrocycles and Protein Loops

(2010) Paul Labute   Journal of Chemical Information and Modeling

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY