The search for exercise factors in humans

Bovine Colostrum Supplementation’s Lack of Effect on Immune Variables During Short-Term Intense Exercise in Well-Trained Athletes

(2016) Arnoud Carol et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Moderate-Intensity Aerobic Training Program Improves Insulin Sensitivity and Inflammatory Markers in a Pilot Study of Morbidly Obese Minority Teens

(2016) Gina Many et al.   PEDIATRIC EXERCISE SCIENCE

Protein Supplementation Increases Postexercise Plasma Myostatin Concentration After 8 Weeks of Resistance Training in Young Physically Active Subjects

(2015) Antonio Paoli et al.   JOURNAL OF MEDICINAL FOOD

Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle

(2014) Etienne Mouisel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effect of exercise training on skeletal muscle cytokine expression in the elderly

(2014) Paul A. Della Gatta et al.   BRAIN BEHAVIOR AND IMMUNITY

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

(2014) Julia Brenmoehl et al.   International Journal of Biological Sciences

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

(2014) Manoja K. Brahma et al.   JOURNAL OF LIPID RESEARCH

Identification of human exercise-induced myokines using secretome analysis

(2014) Milène Catoire et al.   PHYSIOLOGICAL GENOMICS

Single Muscle Fiber Gene Expression with Run Taper

(2014) Kevin Murach et al.   PLoS One

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

(2014) M. Catoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunomodulating role of exercise in metabolic disease

(2014) Graeme I. Lancaster et al.   TRENDS IN IMMUNOLOGY

Inventing new medicines: The FGF21 story

(2014) Alexei Kharitonenkov et al.   Molecular Metabolism

Acute molecular responses in untrained and trained muscle subjected to aerobic and resistance exercise training versus resistance training alone

(2013) R. Fernandez-Gonzalo et al.   Acta Physiologica

Cytokine response of primary human myotubes in an in vitro exercise model

(2013) Mika Scheler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Irisin and exercise training in humans – Results from a randomized controlled training trial

(2013) Anne Hecksteden et al.   BMC Medicine

The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion

(2013) Yun Sok Lee et al.   CELL

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Cytokine response to acute running in recreationally-active and endurance-trained men

(2013) Jonathan P. R. Scott et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects

(2013) Tore Christiansen et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise

(2013) Silja Raschke et al.   MEDIATORS OF INFLAMMATION

Loss of sparc in mouse skeletal muscle causes myofiber atrophy

(2013) Katsuyuki Nakamura et al.   MUSCLE & NERVE

Aerobic exercise + weight loss decreases skeletal muscle myostatin expression and improves insulin sensitivity in older adults

(2013) A.S. Ryan et al.   Obesity

Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats

(2013) Alexandre G. Oliveira et al.   Obesity

Identification and Validation of Novel Contraction-Regulated Myokines Released from Primary Human Skeletal Muscle Cells

(2013) Silja Raschke et al.   PLoS One

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

(2013) Kook Hwan Kim et al.   PLoS One

Inhibition of Myostatin Signaling through Notch Activation following Acute Resistance Exercise

(2013) Matthew G. MacKenzie et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

Acute effects of resistance training on cytokines and osteoprotegerin in women with metabolic syndrome

(2012) Guilherme B. Pereira et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways

(2012) S. Lambernd et al.   DIABETOLOGIA

Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity

(2012) Vincent J. Dalbo et al.   EUROPEAN JOURNAL OF NUTRITION

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

(2012) Wataru Aoi et al.   GUT

Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males

(2012) Melanie Leggate et al.   JOURNAL OF APPLIED PHYSIOLOGY

Extensive inflammatory cell infiltration in human skeletal muscle in response to an ultraendurance exercise bout in experienced athletes

(2012) Peter Marklund et al.   JOURNAL OF APPLIED PHYSIOLOGY

Plasma levels of interleukin-6 and interleukin-18 after an acute physical exercise: relation with post-exercise energy intake in twins

(2012) C. Almada et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

(2012) TOMMY R. LUNDBERG et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB

(2012) Min Suk Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

(2012) Martin Friedrichsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Early inflammatory and myogenic responses to resistance exercise in the elderly

(2012) Jessica L. Mathers et al.   MUSCLE & NERVE

Myogenic, matrix, and growth factor mRNA expression in human skeletal muscle: Effect of contraction intensity and feeding

(2012) Jakob Agergaard et al.   MUSCLE & NERVE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise

(2012) Nataša Nikolić et al.   PLoS One

Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes

(2012) Marius R. Robciuc et al.   PLoS One

Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and Exercising Human Skeletal Muscle

(2012) Milène Catoire et al.   PLoS One

Effect of High- versus Low-Intensity Supervised Aerobic and Resistance Training on Modifiable Cardiovascular Risk Factors in Type 2 Diabetes; The Italian Diabetes and Exercise Study (IDES)

(2012) Stefano Balducci et al.   PLoS One

Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

(2011) Frode Norheim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Resistance exercise increases NF-κB activity in human skeletal muscle

(2011) Luke Vella et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

(2011) Markus F. Neurath et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

(2011) R. Shah et al.   DIABETES

Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?

(2011) Yoshiaki Tamura et al.   ENDOCRINE JOURNAL

Acute metabolic responses to a 24-h ultra-marathon race in male amateur runners

(2011) Zbigniew Waśkiewicz et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair

(2011) Haiyan Lu et al.   FASEB JOURNAL

MSTN mRNA After Varying Exercise Modalities in Humans

(2011) T. Schiffer et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

LIF is a contraction-induced myokine stimulating human myocyte proliferation

(2011) Christa Broholm et al.   JOURNAL OF APPLIED PHYSIOLOGY

Similar changes of gene expression in human skeletal muscle after resistance exercise and multiple fine needle biopsies

(2011) Birgit Friedmann-Bette et al.   JOURNAL OF APPLIED PHYSIOLOGY

Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity

(2011) David C. Nieman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Effect of Exercise Intensity on the Cytokine Response to an Acute Bout of Running

(2011) JONATHAN PAUL RICHARD SCOTT et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

IL-7 is expressed and secreted by human skeletal muscle cells

(2010) Fred Haugen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions

(2010) Puntip Tantiwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

(2010) Vitor A. Lira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SPARC interacts with AMPK and regulates GLUT4 expression

(2010) Haiyan Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling

(2010) Melanie Leggate et al.   CELL STRESS & CHAPERONES

Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1

(2010) Nicole Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Source and kinetics of interleukin-6 in humans during exercise demonstrated by a minimally invasive model

(2010) Anders Dyhr Toft et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Effects of mode and intensity on the acute exercise-induced IL-6 and CRP responses in a sedentary, overweight population

(2010) Amy E. Mendham et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

Proinflammatory Cytokine IL-1  Stimulates IL-8 Synthesis in Mast Cells via a Leukotriene B4 Receptor 2-Linked Pathway, Contributing to Angiogenesis

(2010) G.-Y. Kim et al.   JOURNAL OF IMMUNOLOGY

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance

(2010) DUSTIN S. HITTEL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Dynamics of the Skeletal Muscle Secretome during Myoblast Differentiation

(2010) Jeanette Henningsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Brain-derived Neurotrophic Factor Regulates Satellite Cell Differentiation and Skeltal Muscle Regeneration

(2010) Charlene Clow et al.   MOLECULAR BIOLOGY OF THE CELL

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

(2009) Sander Kersten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men

(2009) S.R. Gray et al.   CYTOKINE

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

(2009) Pernille Hojman et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats

(2009) José C. Rosa Neto et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Glucose ingestion during endurance training in men attenuates expression of myokine receptor

(2009) Thorbjorn C. A. Akerstrom et al.   EXPERIMENTAL PHYSIOLOGY

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

(2009) Peter Rasmussen et al.   EXPERIMENTAL PHYSIOLOGY

Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men

(2009) Juha J. Hulmi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of exercise and muscle type on BDNF, NT-4/5, and TrKB expression in skeletal muscle

(2009) Daniel I. Ogborn et al.   MUSCLE & NERVE

Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle

(2008) Taku Nedachi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammatory gene changes associated with the repeated-bout effect

(2008) Monica J. Hubal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men

(2008) S. R. Gray et al.   CELL STRESS & CHAPERONES

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator-Activated Receptor (PPAR)-  and Is of Metabolic Relevance in Humans

(2008) H. Staiger et al.   DIABETES

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

CC family chemokines directly regulate myoblast responses to skeletal muscle injury

(2008) Linda Yahiaoui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle

(2008) Christa Broholm et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS

Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise

(2007) Richard A. Dennis et al.   PHYSIOLOGICAL GENOMICS